GPR132

Understanding Entity Pages

This page aggregates everything SciDEX knows about GPR132: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GPR132 (G2A) is a proton-sensing G protein-coupled receptor that detects acidic extracellular pH, lactate, and lipid mediators. It plays critical roles in metabolic stress response, immune cell regulation, cancer metastasis, and has emerging implications for neurodegeneration and neuroinflammation

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flowchart TD
    N0["GPR132"]
    N1["Aging"]
    N0 -->|"activates"| N1
    N2["Diabetes"]
    N0 -->|"activates"| N2
    N3["Atherosclerosis"]
    N0 -->|"activates"| N3
    N4["Senescence"]
    N0 -->|"activates"| N4
    N5["LDL"]
    N0 -->|"activates"| N5
    N6["Glycolysis"]
    N0 -->|"activates"| N6
    N7["SRC"]
    N7 -->|"activates"| N0
    N8["AND"]
    N8 -->|"activates"| N0
    N9["AGING"]
    N9 -->|"activates"| N0
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 disease
    class N5 gene
    class N6 pathway
    class N7 gene
    class N8 gene
    class N9 gene