Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Glycolysis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Glycolysis is a biological pathway involved in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with ALS, Aging, Als. Connected to 808 entities in the SciDEX knowledge graph.
| Name | Glycolysis |
| Key Genes/Proteins | HK2, MYC, MTOR, PI3K, AKT, GENES |
| Related Diseases | Carcinoma, Cancer, Als, Tumor, Inflammation |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
Glycolysis["Glycolysis"] -->|"interacts"| Mtor["Mtor"]
Glycolysis["Glycolysis"] -->|"interacts"| Apoptosis["Apoptosis"]
Glycolysis["Glycolysis"] -->|"interacts"| Oxidative_Phosphorylation["Oxidative Phosphorylation"]
Glycolysis["Glycolysis"] -->|"interacts"| Nf__b["Nf-Kappab"]
Glycolysis["Glycolysis"] -->|"interacts"| Akt["Akt"]
Glycolysis["Glycolysis"] -->|"interacts"| Mitophagy["Mitophagy"]
TIGAR["TIGAR"] -->|"activates"| Glycolysis["Glycolysis"]
IDH2["IDH2"] -->|"activates"| Glycolysis["Glycolysis"]
GAIN["GAIN"] -->|"activates"| Glycolysis["Glycolysis"]
TKT["TKT"] -->|"activates"| Glycolysis["Glycolysis"]
style Glycolysis fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Oxidative Stress | causes | phenotype | 0.90 |
| Bladder Cancer Cell Proliferation | promotes | process | 0.90 |
| Renal Ischemia-Reperfusion Injury | contributes_to | disease | 0.88 |
| Alzheimer's Disease | associated_with | disease | 0.85 |
| Dermatomyositis | upregulates | disease | 0.85 |
| Acute Kidney Injury | associated_with | disease | 0.85 |
| Oxidative Stress | contributes_to | process | 0.85 |
| H3K18 Lactylation | promotes | mechanism | 0.85 |
| Ipsc-Cms | associated_with | cell_type | 0.85 |
| Adult Dermatomyositis | associated_with | disease | 0.80 |
| Alzheimer's Disease | involved_in | disease | 0.80 |
| Ferroptosis | regulates | process | 0.80 |
| Neuroinflammation | promotes | process | 0.80 |
| Acute Kidney Injury | contributes_to | disease | 0.75 |
| Cuproptosis | inhibits | process | 0.75 |
| Mtor | interacts_with | pathway | 0.55 |
| Apoptosis | interacts_with | pathway | 0.55 |
| Oxidative Phosphorylation | interacts_with | pathway | 0.55 |
| Nf-Κb | interacts_with | pathway | 0.55 |
| Akt | interacts_with | pathway | 0.55 |
| Mitophagy | interacts_with | pathway | 0.55 |
| Stem Cell | therapeutic_target | cell_type | 0.50 |
| Macrophage | activates | cell_type | 0.50 |
| Stem Cell | activates | cell_type | 0.50 |
| Pericyte | activates | cell_type | 0.50 |
| Endothelial | activates | cell_type | 0.50 |
| Stem Cell | expressed_in | cell_type | 0.50 |
| Macrophage | expressed_in | cell_type | 0.50 |
| T Cell | expressed_in | cell_type | 0.50 |
| Dendritic Cell | expressed_in | cell_type | 0.50 |
| Microglia | regulates | cell_type | 0.50 |
| Macrophage | therapeutic_target | cell_type | 0.50 |
| Microglia | activates | cell_type | 0.50 |
| Monocyte | activates | cell_type | 0.50 |
| Microglia | phosphorylates | cell_type | 0.50 |
| Neuron | activates | cell_type | 0.50 |
| Dopaminergic | activates | cell_type | 0.50 |
| Neuron | inhibits | cell_type | 0.50 |
| Astrocyte | activates | cell_type | 0.50 |
| Astrocyte | inhibits | cell_type | 0.50 |
| Neuron | expressed_in | cell_type | 0.50 |
| Neuron | regulates | cell_type | 0.50 |
| Endothelial | inhibits | cell_type | 0.50 |
| Epithelial | therapeutic_target | cell_type | 0.50 |
| T Cell | activates | cell_type | 0.50 |
| Astrocyte | regulates | cell_type | 0.50 |
| Microglia | causes | cell_type | 0.50 |
| Macrophage | associated_with | cell_type | 0.50 |
| Neuron | associated_with | cell_type | 0.50 |
| Stem Cell | associated_with | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HK2 | activates | gene | 1.00 |
| MYC | activates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| PI3K | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| AKT | regulates | gene | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| GENES | regulates | gene | 1.00 |
| Als | regulates | disease | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| MTOR | regulates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| ASTROCYTES | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| P53 | activates | gene | 1.00 |
| HIF | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| MTOR | inhibits | gene | 1.00 |
| Aging | activates | disease | 1.00 |
| ATP | associated_with | gene | 1.00 |
| Obesity | activates | disease | 1.00 |
| ATP | activates | gene | 1.00 |
| Als | implicated_in | disease | 1.00 |
| ROS | activates | gene | 1.00 |
| Als | inhibits | disease | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Metabolic Reprogramming via Microglial Glycolysis Inhibition | 0.385 | neurodegeneration | Synaptic pruning by microglia in early A |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Bergenin attenuates traumatic brain injury via inhibition of microglial PFKFB3-d [PMID:41520557] | Sun B, Zhang A, Feng S, Jamali AW, Jia Z | Int Immunopharmacol | 2026 | 1 |
| HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Meta [PMID:41387352] | Pesce NA, Seminara G, Giarrusso G, Tomas | Adv Biol (Weinh) | 2026 | 1 |
| Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285] | Fang M, Zhou Y, He K, Lu Y, Tao F, Huang | Mol Neurobiol | 2025 | 1 |
| Deficiency of Microglial Hv1 Protects Against Lipopolysaccharide-Induced Neuroin [PMID:40911376] | Sun L, Wang X, Guan S, Zhang P, Chen D, | FASEB J | 2025 | 1 |
| The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer. [PMID:38904014] | Fontana F, Giannitti G, Marchesi S, Limo | Int J Biol Sci | 2024 | 1 |
| AST-120 alleviates renal ischemia-reperfusion injury by inhibiting HK2-mediated [PMID:39217289] | Zhou J, Zhang J, Xu F, Gao H, Wang L, Zh | Mol Med | 2024 | 1 |
| Hexokinase 2-mediated gene expression via histone lactylation is required for he [PMID:37463576] | Rho H, Terry AR, Chronis C, Hay N | Cell Metab | 2023 | 1 |
| Crosstalk Between [PMID:41899603] | ["Ren Y", "Tang D", "Ding X", "He M"] | Cancers | 2026 | 0 |
| Suoquan Yishen formula attenuates ectopic lipid deposition in diabetic kidney di [PMID:41461331] | Wang J, Lin N, Li X, Ma T, Yuan Y et al. | J Ethnopharmacol | 2026 | 0 |
| Yi-Shen-Hua-Shi granules ameliorate renal injury via PPARγ-Klotho-mediated metab [PMID:41475627] | Gao HZ, Sun LM, Hu D, Li J, Chen CL et a | J Ethnopharmacol | 2026 | 0 |
| Bisphenol A Promotes Ovarian Cancer Proliferation and Migration through the HK2/ [PMID:41885081] | Xie X, Zhang Y, Li Y, Yan Q, Dong J et a | J Agric Food Chem | 2026 | 0 |
| Targeting SAT1 alleviates high glucose-induced tubular ferroptosis and fibrosis: [PMID:41936633] | Tang Y, Wang S, Wang Y, Zhang T, Liu Y e | Histochem Cell Biol | 2026 | 0 |
| SIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic [PMID:41945160] | Jian Y, Zeng Y, Wang Z, Zhou X, Zhang H | Apoptosis | 2026 | 0 |
| Nuclear hexokinase 2 couples hyperglycemia to MYC-driven glycolytic and stemness [PMID:41951587] | Liu S, Liu X, Liu G, Wang Z, Li C et al. | Cell Death Dis | 2026 | 0 |
| Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reduc [PMID:41958068] | Gong D, Chen X, Dong Z, Chen H, Liu Z | Ren Fail | 2026 | 0 |
| Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates [PMID:41960638] | Lin W, Dong C, Jiang Q, Lou Y, Wang L et | Redox Rep | 2026 | 0 |
| Modulation of Aerobic Glycolysis Genes During the Progression of Retinitis Pigme [PMID:41569027] | ["Adani E", "Villa Vasquez S", "Lovino M | Investigative ophthalmology & | 2026 | 0 |
| Duzhong-Gegen formula ameliorated hyperuricemia by enhancing renal uric acid exc [PMID:41905095] | Wang L, Gan Y, Huang J, Long L, Li S, Wa | Phytomedicine : international | 2026 | 0 |
| Mitophagy bridges glucose metabolism, inflammation and neuroprotection in astroc [PMID:41677100] | ["Hakansson H", "Howden J", "Kittler J"] | Autophagy | 2026 | 0 |
| Investigating the Effect and Mechanism of Protocatechuic Aldehyde on Vascular De [PMID:41897347] | ["Xiao T", "Tao J", "Tan J", "Yi X", "Wa | Biomolecules | 2026 | 0 |