Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SRC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SRC is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with AD, ALI, ALS. Connected to 671 entities in the SciDEX knowledge graph.
| Gene Symbol | SRC |
| Protein Type | Receptor |
| Function | SRC encodes a member of the Src family of non-receptor tyrosine kinases (SFKs). |
| Pathways | Apoptosis, Autophagy, Complement, Dendritic Spine, Differentiation |
| Ensembl ID | ENSG00000197122 |
| GeneCards | SRC |
| Human Protein Atlas | SRC |
| Associated Diseases | AD, ALI, ALS, Alzheimer, Autism |
| Known Drugs/Compounds | DOP, DEP |
| Interactions | p38, HK1, MTOR, PTEN, HK2, EGFR |
| KG Connections | 1046 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
SRC(["SRC"])
Cancer["Cancer"]
Tumor["Tumor"]
Als["Als"]
EGFR(["EGFR"])
CANCER(["CANCER"])
Apoptosis["Apoptosis"]
AKT(["AKT"])
APOPTOSIS(["APOPTOSIS"])
ARHGEF7(["ARHGEF7"])
ERK(["ERK"])
RELN["RELN"]
SRC -->|"activates"| Cancer
SRC -->|"activates"| Tumor
SRC -->|"therapeutic target"| Cancer
SRC -->|"activates"| Als
EGFR -->|"activates"| SRC
CANCER -->|"activates"| SRC
SRC -->|"activates"| Apoptosis
AKT -->|"activates"| SRC
CANCER -->|"therapeutic target"| SRC
APOPTOSIS -->|"activates"| SRC
SRC -->|"therapeutic target"| Tumor
SRC -->|"phosphorylates"| ARHGEF7
SRC -->|"activates"| ERK
SRC -->|"interacts with"| RELN
AKT -->|"therapeutic target"| SRC
style SRC fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Tumor | therapeutic_target | disease | 0.95 |
| RELN | interacts_with | entity | 0.90 |
| endocrine therapy resistance | promotes | phenotype | 0.90 |
| ERK | activates | protein | 0.90 |
| Als | therapeutic_target | disease | 0.85 |
| Inflammation | inhibits | disease | 0.85 |
| NEURONAL MIGRATION | involved_in | entity | 0.85 |
| MAPK14 | interacts_with | gene | 0.80 |
| Glycolysis | activates | pathway | 0.80 |
| Apoptosis | therapeutic_target | pathway | 0.80 |
| Invasion | activates | pathway | 0.80 |
| Metastasis | activates | pathway | 0.80 |
| Cancer | interacts_with | disease | 0.75 |
| Carcinoma | interacts_with | disease | 0.75 |
| Tumor | interacts_with | disease | 0.75 |
| Cancer | associated_with | disease | 0.75 |
| Amyotrophic Lateral Sclerosis | therapeutic_target | disease | 0.75 |
| Traumatic Brain Injury | inhibits | disease | 0.75 |
| Carcinoma | activates | disease | 0.75 |
| Tumor | associated_with | disease | 0.75 |
| Cancer | inhibits | disease | 0.75 |
| Cancer | regulates | disease | 0.75 |
| Tumor | regulates | disease | 0.75 |
| Carcinoma | associated_with | disease | 0.75 |
| Als | interacts_with | disease | 0.75 |
| Inflammation | activates | disease | 0.75 |
| Fibrosis | therapeutic_target | disease | 0.75 |
| Inflammation | therapeutic_target | disease | 0.75 |
| Als | regulates | disease | 0.75 |
| MTOR | activates | gene | 0.70 |
| MTOR | regulates | gene | 0.70 |
| Oxidative Phosphorylation | activates | pathway | 0.70 |
| Mtor | activates | pathway | 0.70 |
| Necroptosis | activates | pathway | 0.70 |
| Mapk | activates | pathway | 0.70 |
| Cell Cycle | activates | pathway | 0.70 |
| Oxidative Stress | inhibits | pathway | 0.70 |
| Nf-Κb | inhibits | pathway | 0.70 |
| Mapk | therapeutic_target | pathway | 0.70 |
| Angiogenesis | therapeutic_target | pathway | 0.70 |
| Oxidative Stress | therapeutic_target | pathway | 0.70 |
| Pi3K/Akt | activates | pathway | 0.70 |
| Pi3K/Akt | therapeutic_target | pathway | 0.70 |
| Mtor | regulates | pathway | 0.70 |
| Pi3K/Akt | regulates | pathway | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| EGFR | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| fatty acid β-oxidation | activates | pathway | 0.93 |
| DOP | binds | compound | 0.90 |
| AKT | therapeutic_target | gene | 0.90 |
| PI3K | therapeutic_target | gene | 0.90 |
| Glutamate | activates | compound | 0.85 |
| DEP | binds | compound | 0.85 |
| VLDLR | activates | protein | 0.85 |
| PTK2 | activates | gene | 0.82 |
| PI3K | activates | gene | 0.80 |
| TP53 | therapeutic_target | gene | 0.80 |
| AKT | regulates | gene | 0.80 |
| TUBB3 | activates | gene | 0.75 |
| PIEZO1 | activates | gene | 0.74 |
| STAT3 | activates | gene | 0.70 |
| EGF | activates | gene | 0.70 |
| PTEN | activates | gene | 0.70 |
| EGFR | interacts_with | gene | 0.70 |
| EGFR | therapeutic_target | gene | 0.70 |
| ESR1 | therapeutic_target | gene | 0.70 |
| PI3K | regulates | gene | 0.70 |
| AKT1 | interacts_with | gene | 0.70 |
| AMPK | activates | gene | 0.70 |
| YAP | activates | gene | 0.70 |
| ERK | activates | gene | 0.70 |
| CANCER | associated_with | gene | 0.70 |
| CANCER | regulates | gene | 0.70 |
| ALS | therapeutic_target | gene | 0.70 |
| AMYOTROPHIC LATERAL SCLEROSIS | therapeutic_target | gene | 0.70 |
| RAS | activates | gene | 0.70 |
| JAK | activates | gene | 0.70 |
| APOPTOSIS | therapeutic_target | gene | 0.70 |
| CYTOKINES | inhibits | gene | 0.70 |
| INFLAMMATION | inhibits | gene | 0.70 |
| GENES | interacts_with | gene | 0.70 |
| FYN | causes | gene | 0.65 |
| MAPK | interacts_with | gene | 0.65 |
| JAK | phosphorylates | gene | 0.65 |
| ERK | phosphorylates | gene | 0.65 |
| CANCER | phosphorylates | disease | 0.65 |
| GLIOBLASTOMA | phosphorylates | disease | 0.65 |
| IL6 | activates | protein | 0.64 |
| JUN | regulates | gene | 0.60 |
| DAB1 | associated_with | gene | 0.60 |
| FYN | associated_with | gene | 0.60 |
| TP53 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||