gene

SRC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SRC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1048Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

SRC is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with AD, ALI, ALS. Connected to 671 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSRC
Protein TypeReceptor
FunctionSRC encodes a member of the Src family of non-receptor tyrosine kinases (SFKs).
PathwaysApoptosis, Autophagy, Complement, Dendritic Spine, Differentiation
Ensembl IDENSG00000197122
GeneCardsSRC
Human Protein AtlasSRC
Associated DiseasesAD, ALI, ALS, Alzheimer, Autism
Known Drugs/CompoundsDOP, DEP
Interactionsp38, HK1, MTOR, PTEN, HK2, EGFR
KG Connections1046 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

SRC Gene

gene · 800 words

Novel Therapy Index

idea · 10647 words

NTF4 Protein

protein · 5111 words

TREM2 Mechanism Hub

mechanism · 5099 words

Mitophagy Pathway in Neurodegeneration

mechanism · 4637 words

TREM2 Microglial Signaling Pathway in Neurodegeneration

mechanism · 4613 words

Pathway Diagram

flowchart TD
    SRC(["SRC"])
    Cancer["Cancer"]
    Tumor["Tumor"]
    Als["Als"]
    EGFR(["EGFR"])
    CANCER(["CANCER"])
    Apoptosis["Apoptosis"]
    AKT(["AKT"])
    APOPTOSIS(["APOPTOSIS"])
    ARHGEF7(["ARHGEF7"])
    ERK(["ERK"])
    RELN["RELN"]

    SRC -->|"activates"| Cancer
    SRC -->|"activates"| Tumor
    SRC -->|"therapeutic target"| Cancer
    SRC -->|"activates"| Als
    EGFR -->|"activates"| SRC
    CANCER -->|"activates"| SRC
    SRC -->|"activates"| Apoptosis
    AKT -->|"activates"| SRC
    CANCER -->|"therapeutic target"| SRC
    APOPTOSIS -->|"activates"| SRC
    SRC -->|"therapeutic target"| Tumor
    SRC -->|"phosphorylates"| ARHGEF7
    SRC -->|"activates"| ERK
    SRC -->|"interacts with"| RELN
    AKT -->|"therapeutic target"| SRC

    style SRC fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (652)

TargetRelationTypeStr
Canceractivatesdisease1.00
Tumoractivatesdisease1.00
Cancertherapeutic_targetdisease1.00
Alsactivatesdisease1.00
Apoptosisactivatespathway1.00

Incoming (396)

SourceRelationTypeStr
EGFRactivatesgene1.00
CANCERactivatesgene1.00
AKTactivatesgene1.00
CANCERtherapeutic_targetgene1.00
APOPTOSISactivatesgene1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found