Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Senescence: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Senescence is a disease characterized by neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, Aging, Als. Connected to 1195 entities in the SciDEX knowledge graph.
| DNA damage | Telomere shortening, oxidative DNA lesions, double-strand breaks from mitochondrial dysfunction |
| Oncogenic stress | Pathological protein aggregates (tau, α-synuclein) can activate DNA damage responses |
| Replication stress | Cumulative cell divisions in neural stem cells and glial progenitors |
| Mitochondrial dysfunction | Accumulation of damaged mitochondria with altered redox signaling |
| Proteostatic stress | Chronic accumulation of misfolded proteins activates integrated stress responses |
| Epigenetic changes | Altered DNA methylation patterns and chromatin remodeling |
| Associated Genes | GBA, PLIN2, CGAS, TREM2, APOE, AMPK, P53, OPA1 |
| KG Connections | 1820 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Senescence["Senescence"] -.->|"inhibits"| Nf__b["Nf-Kappab"]
Senescence["Senescence"] -->|"expressed in"| Apoptosis["Apoptosis"]
Senescence["Senescence"] -->|"activates"| Angiogenesis["Angiogenesis"]
Senescence["Senescence"] -->|"therapeutic target"| Epigenetic["Epigenetic"]
Senescence["Senescence"] -->|"activates"| Mitochondrial_Function["Mitochondrial Function"]
Senescence["Senescence"] -->|"associated"| Epigenetic_1["Epigenetic"]
TGM2["TGM2"] -.->|"inhibits"| Senescence["Senescence"]
GBA["GBA"] -->|"associated"| Senescence["Senescence"]
PLIN2["PLIN2"] -->|"associated"| Senescence["Senescence"]
FAS["FAS"] -->|"regulates"| Senescence["Senescence"]
style Senescence fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | associated_with | disease | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Cell Cycle | regulates | pathway | 1.00 |
| Cell Cycle | associated_with | pathway | 1.00 |
| Telomere | associated_with | pathway | 1.00 |
| Dna Repair | regulates | pathway | 1.00 |
| Epigenetic | associated_with | pathway | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Epigenetic | activates | pathway | 1.00 |
| Cell Cycle | activates | pathway | 1.00 |
| Differentiation | activates | pathway | 1.00 |
| Epigenetic | inhibits | pathway | 0.95 |
| Inflammation | therapeutic_target | disease | 0.95 |
| Aging | contributes_to | process | 0.95 |
| Cellular Aging | involved_in | process | 0.95 |
| Cellular Damage | causes | phenotype | 0.90 |
| Cell Proliferation | inhibits | process | 0.90 |
| Senescence-Associated Secretory Phenotype | mediates | phenotype | 0.90 |
| Leukemia Cell Resistance | associated_with | phenotype | 0.90 |
| Epigenetic | regulates | pathway | 0.90 |
| Mtor | activates | pathway | 0.90 |
| Apoptosis | inhibits | pathway | 0.90 |
| Pi3K/Akt | activates | pathway | 0.90 |
| Stem Cell | associated_with | pathway | 0.90 |
| Stem Cell | inhibits | pathway | 0.90 |
| Cancer Progression | contributes_to | process | 0.85 |
| Senescence Associated Secretory Phenotype | contributes_to | phenotype | 0.85 |
| Tumorigenicity | contributes_to | phenotype | 0.85 |
| Inflammation | regulates | disease | 0.85 |
| Inflammation | activates | disease | 0.85 |
| Cardiovascular Disease | risk_factor_for | disease | 0.85 |
| Diabetes | risk_factor_for | disease | 0.85 |
| Cancer | risk_factor_for | disease | 0.85 |
| Pulmonary Vascular Endothelial Cells | involved_in | cell_type | 0.85 |
| Alzheimer's Disease | associated_with | disease | 0.85 |
| Parkinson's Disease | associated_with | disease | 0.85 |
| Endothelial Cell Dysfunction | contributes_to | phenotype | 0.85 |
| Telomeric Alteration | regulates | mechanism | 0.80 |
| Microtubular Reorganization | regulates | process | 0.80 |
| Autophagic Clearance | regulates | process | 0.80 |
| Glioma | contributes_to | disease | 0.80 |
| Alzheimer's Disease | contributes_to | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Cancer | associated_with | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| DNA | regulates | gene | 1.00 |
| Cardiovascular | associated_with | disease | 1.00 |
| GENES | regulates | gene | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| STING | activates | gene | 1.00 |
| CGAS | activates | gene | 1.00 |
| Atherosclerosis | associated_with | disease | 1.00 |
| AMPK | activates | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| P53 | regulates | gene | 1.00 |
| DNA | inhibits | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| AGING | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| AGING | regulates | gene | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| CGAS-STING | activates | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| IL-6 | activates | gene | 1.00 |
| AGING | activates | gene | 1.00 |
| P53 | inhibits | gene | 1.00 |
| P53 | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | associated_with | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675
neurodegeneration | 2026-04-14 | 0 hypotheses
cellular senescence | 2026-04-11 | 0 hypotheses
cell biology | 2026-04-08 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Klebsiella pneumoniae Induces Ferroptosis and Lactation Dysfunction in Bovine Ma [PMID:40937759] | Mao P, Wang Z, Duan J, Dong P, Yuan C, L | J Agric Food Chem | 2025 | 1 |
| Targeting ferroptosis: novel therapeutic approaches and intervention strategies [PMID:41425591] | Luo Y, Long M, Wu X, Zeng L | Front Immunol | 2025 | 1 |
| Trimetazidine attenuates Ischemia/Reperfusion-Induced myocardial ferroptosis by [PMID:39134283] | Tan M, Yin Y, Chen W, Zhang J, Jin Y, Zh | Biochem Pharmacol | 2024 | 1 |
| Copy number deletion of PLA2G4A affects the susceptibility and clinical phenotyp [PMID:38816399] | Gao Z, Guo X, Sun Z, Wu S, Wang Q, Huang | Schizophrenia (Heidelb) | 2024 | 1 |
| Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and De [PMID:38580317] | Velma GR, Krider IS, Alves ETM, Courey J | J Med Chem | 2024 | 1 |
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| TREM2, microglia, and Alzheimer's disease. [PMID:33516818] | Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang | Mech Ageing Dev | 2021 | 1 |
| NAD(+) metabolism, stemness, the immune response, and cancer. [PMID:33384409] | Navas LE, Carnero A | Signal Transduct Target Ther | 2021 | 1 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| NAD metabolism fuels human and mouse intestinal inflammation. [PMID:28877980] | Gerner RR, Klepsch V, Macheiner S, Arnha | Gut | 2018 | 1 |
| TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038] | Ulland TK, Song WM, Huang SC, Ulrich JD, | Cell | 2017 | 1 |
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663] | Krasemann S, Madore C, Cialic R, Baufeld | Immunity | 2017 | 1 |
| NAD+ and sirtuins in aging and disease. [PMID:24786309] | Imai S, Guarente L | Trends Cell Biol | 2014 | 1 |
| Lipoprotein-associated and secreted phospholipases A₂ in cardiovascular disease: [PMID:21098459] | Mallat Z, Lambeau G, Tedgui A | Circulation | 2010 | 1 |
| Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin prod [PMID:18811942] | Godkin JD, Roberts MP, Elgayyar M, Guan | Reprod Biol Endocrinol | 2008 | 1 |
| Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042] | ["Lyu G", "Li D"] | CNS & neurological disorders d | 2026 | 0 |
| Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuro [PMID:41858793] | ["Wang R", "Feng Y", "Zhou Z", "Jiang J" | Frontiers in aging neuroscienc | 2026 | 0 |
| Human CSF proteogenomics links genetic variation to neurodegenerative disease pr [PMID:41757182] | ["Puerta R", "Garc\u00eda-Gonz\u00e1lez | medRxiv : the preprint server | 2026 | 0 |
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Molecular neurodegeneration | 2026 | 0 |
| TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604] | Yang HC, Deng YS, Zhang J, Zhang T, Song | J Alzheimers Dis | 2026 | 0 |