disease

Atherosclerosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Atherosclerosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2103Connections

0Hypotheses

4Analyses

50Outgoing

50Incoming

Summary

Atherosclerosis is a disease characterized by neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 1020 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	GBM, C1QA, C1QC, SPI1, APOE, LRP8, LRP5, LRP1
Therapeutic Agents	Xue-Jie-San, Imidazole Propionate, Luteolin
KG Connections	1648 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Atherosclerosis["Atherosclerosis"] -.->|"inhibits"| Autophagy["Autophagy"]
    Atherosclerosis["Atherosclerosis"] -.->|"inhibits"| Akt["Akt"]
    Atherosclerosis["Atherosclerosis"] -.->|"inhibits"| Pi3K["Pi3K"]
    Atherosclerosis["Atherosclerosis"] -->|"activates"| Cholesterol["Cholesterol"]
    Atherosclerosis["Atherosclerosis"] -.->|"inhibits"| Mtor["Mtor"]
    Atherosclerosis["Atherosclerosis"] -->|"associated"| Complement["Complement"]
    ACTB["ACTB"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    P2RY12["P2RY12"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    APOA1["APOA1"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ULK1["ULK1"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    style Atherosclerosis fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (596)

Target	Relation	Type	Str
Inflammation	associated_with	disease	1.00
Lipid Metabolism	regulates	pathway	1.00
Cholesterol	regulates	pathway	1.00
Inflammasome	activates	pathway	1.00
Senescence	associated_with	disease	1.00
Inflammation	activates	disease	1.00
Inflammation	inhibits	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Inflammation	causes	disease	1.00
Inflammation	contributes_to	disease	1.00
Lipid Metabolism	associated_with	pathway	1.00
Mtor	therapeutic_target	pathway	1.00
Cholesterol	inhibits	pathway	1.00
Oxidative Stress	activates	pathway	1.00
Microrna	regulates	pathway	1.00
Cholesterol	associated_with	pathway	0.95
Inflammation	implicated_in	disease	0.95
Cardiovascular Disease	causes	disease	0.95
Vascular Remodelling	associated_with	process	0.95
Cardiovascular Diseases	causes	disease	0.95
Alzheimer'S Disease	risk_factor_for	disease	0.95
Cardiovascular Morbidity And Mortality	causes	phenotype	0.95
Stroke	risk_factor_for	disease	0.90
Coronary Artery Disease	causes	disease	0.90
Cholesterol	activates	pathway	0.90
Autophagy	activates	pathway	0.90
Mtor	activates	pathway	0.90
Lipid Metabolism	therapeutic_target	pathway	0.90
Nf-Κb	inhibits	pathway	0.90
Oxidative Stress	treats	pathway	0.90
Epigenetic	therapeutic_target	pathway	0.90
Oxidative Stress	therapeutic_target	pathway	0.90
Lipid Metabolism	activates	pathway	0.90
Cardiovascular	associated_with	disease	0.85
Cardiovascular	therapeutic_target	disease	0.85
Cardiovascular	activates	disease	0.85
Vascular Brain Injury	causes	process	0.85
Heart Failure	causes	disease	0.85
Alzheimer's Disease	risk_factor_for	disease	0.80
Mtor	inhibits	pathway	0.80
Nf-Κb	regulates	pathway	0.80
Mapk	therapeutic_target	pathway	0.80
Differentiation	implicated_in	pathway	0.80
Toll-Like Receptor	activates	pathway	0.80
Immune Response	therapeutic_target	pathway	0.80
Cholesterol	therapeutic_target	pathway	0.80
Nf-Κb	therapeutic_target	pathway	0.80
Autophagy	therapeutic_target	pathway	0.80
Differentiation	regulates	pathway	0.80
Angiogenesis	regulates	pathway	0.80

Incoming (1507)

Source	Relation	Type	Str
APOE	inhibits	gene	1.00
APOE	associated_with	gene	1.00
GENES	therapeutic_target	gene	1.00
Diabetes	associated_with	disease	1.00
Als	associated_with	disease	1.00
Cancer	associated_with	disease	1.00
Cardiovascular	associated_with	disease	1.00
GENES	regulates	gene	1.00
APOE	activates	gene	1.00
NF-ΚB	inhibits	gene	1.00
CANCER	associated_with	gene	1.00
INFLAMMATION	contributes_to	gene	1.00
INFLAMMATION	inhibits	gene	1.00
INFLAMMATION	activates	gene	1.00
INFLAMMATION	associated_with	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
CYTOKINES	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
AGING	activates	gene	1.00
AGING	associated_with	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
LDL	inhibits	gene	1.00
INFLAMMATION	causes	gene	1.00
INFLAMMATION	implicated_in	gene	1.00
Als	activates	disease	1.00
Aging	associated_with	disease	1.00
Als	therapeutic_target	disease	1.00
Als	regulates	disease	1.00
LDL	activates	gene	1.00
MICRORNAS	regulates	gene	1.00
MTOR	therapeutic_target	gene	0.95
APOE	therapeutic_target	gene	0.95
Stroke	associated_with	disease	0.95
GENES	associated_with	gene	0.95
AMPK	activates	gene	0.95
MTOR	activates	gene	0.95
TNF	therapeutic_target	gene	0.95
CYTOKINES	therapeutic_target	gene	0.95
NF-ΚB	therapeutic_target	gene	0.95
NLRP3	activates	gene	0.95
AUTOPHAGY	activates	gene	0.95
INFLAMMATION	regulates	gene	0.95
STROKE	associated_with	gene	0.95
GENES	activates	gene	0.95
C1Q	risk_factor_for	gene	0.95
Cardiovascular	therapeutic_target	disease	0.95
OXIDATIVE STRESS	treats	gene	0.95
Als	inhibits	disease	0.95
MIRNAS	regulates	gene	0.95
Cardiac	associated_with	disease	0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (4)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Atherosclerosis

Understanding Entity Pages

Summary

Wiki Pages (20)

Vascular Cognitive Impairment (VCI)

Lipid Peroxidation in Neurodegeneration

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

Type 3 Diabetes Hypothesis of Alzheimer's Disease

gladstone

Pathway Diagram

Outgoing (596)

Incoming (1507)

Targeting Hypotheses (0)

Mentioning Analyses (4)

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

What are the specific molecular mechanisms by which C1Q components drive atheros

What determines P2RY12 receptor expression/activity specifically in VSMCs during

How does P2RY12-mediated VSMC dysfunction contribute to cerebrovascular neurodeg

Related Papers (0)

Atherosclerosis

Understanding Entity Pages

Summary

Wiki Pages (20)

Vascular Cognitive Impairment (VCI)

Lipid Peroxidation in Neurodegeneration

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

Type 3 Diabetes Hypothesis of Alzheimer's Disease

gladstone

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

Nurr1 (NR4A2) Pathway in Parkinson's Disease

Demyelination

MAPK/ERK Signaling Pathway in Neurodegeneration

ATF3 Protein

Metabolic Dysfunction in Alzheimer's Disease

PPP1R15B

AKT2 Gene

ERK1 Protein

Glymphatic System and Aβ Clearance in Alzheimer's Disease

Neuritic Plaques

one-carbon-metabolism-neurodegeneration

ZBP1 (Z-DNA Binding Protein 1)

Ferroptosis in Alzheimer's Disease

cxcr4

Pathway Diagram

Outgoing (596)

Incoming (1507)

Targeting Hypotheses (0)

Mentioning Analyses (4)

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

What are the specific molecular mechanisms by which C1Q components drive atheros

What determines P2RY12 receptor expression/activity specifically in VSMCs during

How does P2RY12-mediated VSMC dysfunction contribute to cerebrovascular neurodeg

Related Papers (0)