concept

LDL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LDL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

812Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

LDL is a concept in neurodegeneration research. Key relationships include: inhibits, activates, associated with. Associated with AD, ALI, ALS. Connected to 342 entities in the SciDEX knowledge graph.

View on Wiki →

💡 Concept Info

Name	LDL
Key Genes/Proteins	APOE, LDLR
Related Diseases	Atherosclerosis, Als, Inflammation, Aging, Cardiovascular
Related Pathways	oxidative stress response, Lipid Metabolism, Cholesterol

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LDL["LDL"]
    LDL -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    LDL -->|"activates"| ALS["ALS"]
    LDL -->|"inhibits"| Inflammation["Inflammation"]
    LDL -->|"inhibits"| Cardiovascular["Cardiovascular"]
    LDL -->|"interacts"| AMPK["AMPK"]
    LDL -->|"interacts"| ACTB["ACTB"]
    LDLR["LDLR"] -->|"regulates"| LDL
    ABCA1["ABCA1"] -->|"interacts"| LDL
    MTOR["MTOR"] -->|"inhibits"| LDL
    P62["P62"] -->|"interacts"| LDL
    LC3["LC3"] -->|"interacts"| LDL
    APOE["APOE"] -->|"inhibits"| LDL
    SQSTM1["SQSTM1"] -->|"interacts"| LDL
    GAIN["GAIN"] -->|"inhibits"| LDL
    PCSK9["PCSK9"] -->|"inhibits"| LDL

Outgoing (515)

Target	Relation	Type	Str
Atherosclerosis	inhibits	disease	1.00
APOE	inhibits	gene	1.00
Als	inhibits	disease	1.00
Atherosclerosis	activates	disease	1.00
Inflammation	inhibits	disease	0.95
Inflammation	activates	disease	0.95
oxidative stress response	participates_in	pathway	0.90
Lipid Metabolism	activates	pathway	0.90
Cholesterol	activates	pathway	0.90
Cholesterol	inhibits	pathway	0.90
Cholesterol	associated_with	pathway	0.90
Aging	associated_with	disease	0.85
Cardiovascular	inhibits	disease	0.85
Cardiovascular	regulates	disease	0.85
Atherosclerosis	regulates	disease	0.85
Myocardial Infarction	associated_with	disease	0.85
Als	associated_with	disease	0.85
macrophages	expressed_in	cell_type	0.80
Ceramide	transports	compound	0.80
unfolded protein response	participates_in	pathway	0.80
spinal muscular atrophy	associated_with	disease	0.80
ceramide	interacts_with	compound	0.80
GENES	associated_with	gene	0.80
APOE	associated_with	gene	0.80
Nf-Κb	inhibits	pathway	0.80
APOE	activates	gene	0.80
Stroke	associated_with	disease	0.75
Atherosclerosis	associated_with	disease	0.75
Cardiovascular	associated_with	disease	0.75
Nafld	activates	disease	0.75
Inflammation	treats	disease	0.75
Tumor	inhibits	disease	0.75
Fatty Liver	activates	disease	0.75
Als	treats	disease	0.75
Fibrosis	inhibits	disease	0.75
Cardiovascular	protects_against	disease	0.75
Stroke	inhibits	disease	0.75
Coronary Artery Disease	associated_with	disease	0.75
Inflammation	associated_with	disease	0.75
AKT	inhibits	gene	0.70
Mtor	inhibits	pathway	0.70
LDLR	activates	gene	0.70
INFLAMMATION	inhibits	gene	0.70
SREBP2	regulates	gene	0.70
MTOR	inhibits	gene	0.70
AKT	activates	gene	0.70
Lipid Metabolism	regulates	pathway	0.70
Lipid Metabolism	associated_with	pathway	0.70
Cholesterol	regulates	pathway	0.70
autophagy pathway	participates_in	pathway	0.70

Incoming (297)

Source	Relation	Type	Str
LDLR	regulates	protein	0.97
INFLAMMATION	activates	gene	0.80
PCSK9	inhibits	gene	0.70
LDLR	associated_with	gene	0.70
STROKE	associated_with	gene	0.70
LDLR	activates	gene	0.70
PI3K	activates	gene	0.70
IL-6	associated_with	gene	0.70
NF-ΚB	inhibits	gene	0.70
INFLAMMATION	inhibits	gene	0.70
TNF	inhibits	gene	0.70
TNF-Α	inhibits	gene	0.70
INFLAMMATION	associated_with	gene	0.70
ABCA1	activates	gene	0.70
statins	activates	compound	0.70
APOE	interacts_with	gene	0.65
ABCA1	interacts_with	gene	0.60
MTOR	inhibits	gene	0.60
P62	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
APOE	inhibits	gene	0.60
SQSTM1	interacts_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
LRP6	associated_with	gene	0.60
LRP5	associated_with	gene	0.60
GAIN	inhibits	gene	0.60
C1QA	expressed_in	gene	0.60
C1QC	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
REELIN	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
TAU	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
APOE3	inhibits	gene	0.60
TAU PATHOLOGY	inhibits	gene	0.60
APOE4	inhibits	gene	0.60
LDLR	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
GENES	inhibits	gene	0.60
ERK	regulates	gene	0.60
TNF	biomarker_for	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
PI3K	inhibits	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
IL-6	biomarker_for	gene	0.60
FAS	inhibits	gene	0.60
TNF-Α	biomarker_for	gene	0.60
AXON	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LDL

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Astrocyte Reactivity Mechanism

APOC4 — Apolipoprotein C-IV

omega-3-fatty-acids-neurodegeneration

Vascular Cognitive Impairment (VCI)

Blood-Brain Barrier Biology and Crossing Strategies

Niemann-Pick Disease Type C (NPC)

PEN2 Gene

Nanomedicine Approaches to Alzheimer's Disease

Lipid Metabolism Dysfunction Comparison — AD/PD/ALS/FTD/HD

rapamycin-tauopathy

PSEN2 — Presenilin 2

blood-brain-barrier-endothelial-cells

Receptor-Mediated Transcytosis (RMT)

Exosome-Based Drug Delivery for CBS/PSP

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

niemann-pick-disease