concept

LDL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LDL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

775Connections

12Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

LDL is a concept in neurodegeneration research. Key relationships include: inhibits, activates, associated with. Associated with AD, ALI, ALS. Connected to 342 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	LDL
Key Genes/Proteins	ABCA1, ABCG1, ACACA, ACC, ACE, ACETYL-COA
Related Diseases	AD, Aging
Linked Hypotheses	12 hypotheses

Wiki Pages (9)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LDL["LDL"]
    LDL -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    LDL -->|"activates"| ALS["ALS"]
    LDL -->|"inhibits"| Inflammation["Inflammation"]
    LDL -->|"inhibits"| Cardiovascular["Cardiovascular"]
    LDL -->|"interacts"| AMPK["AMPK"]
    LDL -->|"interacts"| ACTB["ACTB"]
    LDLR["LDLR"] -->|"regulates"| LDL
    ABCA1["ABCA1"] -->|"interacts"| LDL
    MTOR["MTOR"] -->|"inhibits"| LDL
    P62["P62"] -->|"interacts"| LDL
    LC3["LC3"] -->|"interacts"| LDL
    APOE["APOE"] -->|"inhibits"| LDL
    SQSTM1["SQSTM1"] -->|"interacts"| LDL
    GAIN["GAIN"] -->|"inhibits"| LDL
    PCSK9["PCSK9"] -->|"inhibits"| LDL

Outgoing (489)

Target	Relation	Type	Str
LDL	encodes	protein	0.00
APOE	inhibits	gene	1.00
Atherosclerosis	inhibits	disease	1.00
Als	inhibits	disease	1.00
Atherosclerosis	activates	disease	1.00
Inflammation	activates	disease	0.95
Inflammation	inhibits	disease	0.95
oxidative stress response	participates_in	pathway	0.90
Cholesterol	inhibits	pathway	0.90
Cholesterol	activates	pathway	0.90
Cholesterol	associated_with	pathway	0.90
Lipid Metabolism	activates	pathway	0.90
Als	associated_with	disease	0.85
Cardiovascular	inhibits	disease	0.85
Aging	associated_with	disease	0.85
Myocardial Infarction	associated_with	disease	0.85
Atherosclerosis	regulates	disease	0.85
Cardiovascular	regulates	disease	0.85
ceramide	interacts_with	compound	0.80
macrophages	expressed_in	cell_type	0.80
unfolded protein response	participates_in	pathway	0.80
Ceramide	transports	compound	0.80
spinal muscular atrophy	associated_with	disease	0.80
GENES	associated_with	gene	0.80
APOE	associated_with	gene	0.80
APOE	activates	gene	0.80
Nf-Κb	inhibits	pathway	0.80
Stroke	inhibits	disease	0.75
Inflammation	associated_with	disease	0.75
Nafld	activates	disease	0.75
Cardiovascular	protects_against	disease	0.75
Tumor	inhibits	disease	0.75
Fibrosis	inhibits	disease	0.75
Inflammation	treats	disease	0.75
Coronary Artery Disease	associated_with	disease	0.75
Fatty Liver	activates	disease	0.75
Cardiovascular	associated_with	disease	0.75
Atherosclerosis	associated_with	disease	0.75
Stroke	associated_with	disease	0.75
Als	treats	disease	0.75
Mtor	inhibits	pathway	0.70
neural stem cells	activates	cell_type	0.70
LDLR	activates	gene	0.70
MTOR	inhibits	gene	0.70
AKT	inhibits	gene	0.70
INFLAMMATION	inhibits	gene	0.70
lipid metabolism	participates_in	pathway	0.70
AKT	activates	gene	0.70
Cholesterol	regulates	pathway	0.70
endothelial cells	expressed_in	cell_type	0.70

Incoming (286)

Source	Relation	Type	Str
LDL	encodes	gene	0.00
LDLR	regulates	protein	0.97
INFLAMMATION	activates	gene	0.80
NF-ΚB	inhibits	gene	0.70
TNF-Α	inhibits	gene	0.70
TNF	inhibits	gene	0.70
IL-6	associated_with	gene	0.70
INFLAMMATION	inhibits	gene	0.70
PI3K	activates	gene	0.70
PCSK9	inhibits	gene	0.70
ABCA1	activates	gene	0.70
INFLAMMATION	associated_with	gene	0.70
LDLR	associated_with	gene	0.70
LDLR	activates	gene	0.70
STROKE	associated_with	gene	0.70
statins	activates	compound	0.70
APOE	interacts_with	gene	0.65
GENES	regulates	gene	0.60
SRC	activates	gene	0.60
AGING	activates	gene	0.60
GPR132	activates	gene	0.60
VESICLE TRAFFICKING	contributes_to	gene	0.60
SREBF2	contributes_to	gene	0.60
FASN	contributes_to	gene	0.60
SREBF1	contributes_to	gene	0.60
CANCER	regulates	gene	0.60
APOB	associated_with	gene	0.60
PCSK9	associated_with	gene	0.60
LDLR	expressed_in	gene	0.60
GENE MUTATIONS	expressed_in	gene	0.60
ACETYL-COA	inhibits	gene	0.60
JAK	inhibits	gene	0.60
TLR4	activates	gene	0.60
ACACA	contributes_to	gene	0.60
APOE3	causes	gene	0.60
ALZHEIMER	causes	gene	0.60
TAU	causes	gene	0.60
NGF	activates	gene	0.60
AMYLOID	activates	gene	0.60
APP	activates	gene	0.60
C-JUN	activates	gene	0.60
BDNF	activates	gene	0.60
IGF-1	activates	gene	0.60
ERK1/2	activates	gene	0.60
LRP1	activates	gene	0.60
IDE	activates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
MITOCHONDRIAL DYSFUNCTION	causes	gene	0.60
GENES	associated_with	gene	0.60
MIRNAS	regulates	gene	0.60

Targeting Hypotheses (12)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LDLR Ligand-Binding Domain A Fusion for Receptor-Mediated Tr	0.650	neurodegeneration	Blood-brain barrier antibody transport m
APOE4 preferentially signals through LRP1 over LDLR, alterin	0.610	neuroscience	APOE4-driven lipid metabolism dysregulat
oxLDL/LOX-1/ROS Signaling Induces P2RY12 via Nrf2 Activation	0.550	neurodegeneration	What determines P2RY12 receptor expressi
LDLR-Targeted Anti-Inflammatory Antibody Delivery for Neuroi	0.498	neuropharmacology	What is the actual quantitative contribu
LDLR-Primed LRP1 Transcytosis with Endosomal Liberation Stra	0.380	neuropharmacology	What is the actual quantitative contribu

LDLR-Primed LRP1 Transcytosis with pH-Activated Endosomal Es	0.380	neuropharmacology	What is the actual quantitative contribu
LDLR-Mediated Neuroinflammation Modulation Strategy	0.380	neuropharmacology	What is the actual quantitative contribu
LDLR-Mediated Lipid Carrier Neurotherapeutic Delivery	0.380	neuropharmacology	What is the actual quantitative contribu
LDLR-Mediated Reverse Cholesterol Transport Modulation for C	0.380	neuropharmacology	What is the actual quantitative contribu
Poorly lipidated APOE4 particles are preferentially routed t	0.340	molecular-biology	Does APOE4's reduced lipid-binding direc
LDLR-Mediated Neurosteroid Precursor Delivery Strategy	0.000	neuropharmacology	What is the actual quantitative contribu
LDLR-Primed LRP1 Transcytosis with pH-Responsive Escape Stra	0.000	neuropharmacology	What is the actual quantitative contribu

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LDL in their description or question text

LDL

Understanding Entity Pages

Summary

Wiki Pages (9)

VLDL Receptor

LDLRAD3 (LDLR Adapter Protein 1) Protein

LDLRAP1 — Low Density Lipoprotein Receptor Adaptor Protein 1

LDL Receptor Protein

LRP4 Protein - LDL Receptor-Related Protein 4

Pathway Diagram

Outgoing (489)

Incoming (286)

Targeting Hypotheses (12)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)

Debates (0)

Related Research

LDLR-Primed LRP1 Transcytosis with pH-Activated Endosomal Escape

LDLR-Mediated Neuroinflammation Modulation Strategy

LDLR-Mediated Lipid Carrier Neurotherapeutic Delivery

LDLR-Mediated Reverse Cholesterol Transport Modulation for CNS Drug Delivery

Poorly lipidated APOE4 particles are preferentially routed through LDLR/LRP1 int

LDLR-Mediated Neurosteroid Precursor Delivery Strategy

LDLR-Primed LRP1 Transcytosis with pH-Responsive Escape Strategy

LDL

Understanding Entity Pages

Summary

Wiki Pages (9)

VLDL Receptor

LDLRAD3 (LDLR Adapter Protein 1) Protein

LDLRAP1 — Low Density Lipoprotein Receptor Adaptor Protein 1

LDL Receptor Protein

LRP4 Protein - LDL Receptor-Related Protein 4

LDLR Gene

LRP5 Protein - LDL Receptor-Related Protein 5

LRP1B Protein - LDL Receptor-Related Protein 1B

LDLR Protein (Low-Density Lipoprotein Receptor)

Pathway Diagram

Outgoing (489)

Incoming (286)

Targeting Hypotheses (12)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)

Debates (0)

Related Research

LDLR-Primed LRP1 Transcytosis with pH-Activated Endosomal Escape

LDLR-Mediated Neuroinflammation Modulation Strategy

LDLR-Mediated Lipid Carrier Neurotherapeutic Delivery

LDLR-Mediated Reverse Cholesterol Transport Modulation for CNS Drug Delivery

Poorly lipidated APOE4 particles are preferentially routed through LDLR/LRP1 int

LDLR-Mediated Neurosteroid Precursor Delivery Strategy

LDLR-Primed LRP1 Transcytosis with pH-Responsive Escape Strategy