Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about lysosomal_biogenesis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
A mechanism referenced in 1 knowledge graph relationship. Key connections: TFEB (protein) promotes.
| Name | lysosomal_biogenesis |
| Key Genes/Proteins | C9ORF72 |
| Linked Hypotheses | 6 hypotheses |
Knowledge base pages for this entity
flowchart TD
N0["LYSOSOMAL BIOGENESIS"]
N1["C9ORF72"]
N1 -->|"regulates"| N0
N2["AUTOPHAGY"]
N0 -->|"regulates"| N2
N3["Autophagy"]
N0 -->|"regulates"| N3
N4["LYSOSOME"]
N0 -->|"activates"| N4
N5["Als"]
N0 -->|"regulates"| N5
N6["Tumor"]
N0 -->|"activates"| N6
N7["Neurodegeneration"]
N0 -->|"causes"| N7
N8["TSC2"]
N0 -->|"activates"| N8
N9["Mtor"]
N0 -->|"regulates"| N9
N10["NEURODEGENERATION"]
N0 -->|"causes"| N10
N11["MTOR"]
N0 -->|"activates"| N11
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 gene
class N2 gene
class N3 pathway
class N4 gene
class N5 disease
class N6 disease
class N7 disease
class N8 gene
class N9 pathway
class N10 gene
class N11 gene| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| C9ORF72 | regulates | gene | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosoma | 0.560 | neurodegeneration | Does TRPML1 enhancement cause therapeuti |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||