TFEB

Understanding Entity Pages

This page aggregates everything SciDEX knows about TFEB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

A protein referenced in 2 knowledge graph relationships. Key connections: promotes lysosomal_biogenesis (mechanism); semaglutide (drug) activates.

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graph TD
    TFEB["TFEB<br/>(Master Regulator)"]
    
    subgraph Activators["TFEB Activators"]
        TRIM27["TRIM27<br/>(E3 Ligase)"]
        CREB1["CREB1<br/>(Transcription Factor)"]
        trehalose["Trehalose<br/>(Metabolite)"]
        QGJZF["QGJZF"]
    end
    
    subgraph Regulators["Upstream Regulators"]
        MTORC1["mTORC1<br/>(Kinase Complex)"]
        AMBRA1["AMBRA1<br/>(Autophagy Regulator)"]
    end
    
    subgraph TargetGenes["Target Genes/Proteins"]
        LC3["LC3<br/>(Autophagy Marker)"]
        RRAG["RRAG<br/>(Lysosomal Positioning)"]
        BECN1["BECN1<br/>(Autophagy Initiator)"]
    end
    
    subgraph Pathways["Regulated Pathways"]
        autophagy["Autophagy"]
        endocytosis["Endocytosis"]
        lysosomal_biogenesis["Lysosomal Biogenesis"]
        autophagic_pathway["Autophagy-Lysosomal Pathway"]
    end
    
    subgraph Outcomes["Physiological Outcomes"]
        neurodegen["Neurodegenerative Disease<br/>Modulation"]
        alzheimers["Alzheimer's Disease<br/>Treatment"]
    end
    
    TRIM27 -->|"activates"| TFEB
    CREB1 -->|"activates"| TFEB
    trehalose -->|"activates"| TFEB
    QGJZF -->|"activates"| TFEB
    
    MTORC1 -->|"regulates"| TFEB
    AMBRA1 -->|"inhibits"| TFEB
    
    TFEB -->|"regulates"| LC3
    TFEB -->|"regulates"| RRAG
    TFEB -->|"activates"| BECN1
    
    TFEB -->|"activates"| autophagy
    TFEB -->|"promotes"| endocytosis
    TFEB -->|"regulates"| lysosomal_biogenesis
    TFEB -->|"activates"| autophagic_pathway
    
    autophagy -->|"linked to"| neurodegen
    autophagic_pathway -->|"related to"| alzheimers
    TFEB -->|"modulates"| neurodegen
    TFEB -->|"treats"| alzheimers
    
    classDef mainProtein fill:#ff6b6b,stroke:#c92a2a,stroke-width:3px,color:#e0e0e0,font-weight:bold
    classDef protein fill:#4ecdc4,stroke:#1a9b8e,stroke-width:2px,color:#e0e0e0
    classDef pathway fill:#95e1d3,stroke:#38ada9,stroke-width:2px,color:#e0e0e0
    classDef outcome fill:#ffd93d,stroke:#f39c12,stroke-width:2px,color:#e0e0e0
    classDef regulator fill:#a8dadc,stroke:#457b9d,stroke-width:2px,color:#e0e0e0
    
    class TFEB mainProtein
    class TRIM27,CREB1,LC3,RRAG,BECN1,QGJZF,trehalose,MTORC1,AMBRA1 protein
    class autophagy,endocytosis,lysosomal_biogenesis,autophagic_pathway pathway
    class neurodegen,alzheimers outcome
    class Activators,Regulators regulator