mechanism 2,534 words KG: ent-gene-f7979b3d
Contents

ATP13A2 (PARK9) Pathway in Parkinson's Disease

🔬 Protein Info
Gene Symbolent-gene-f7979b3d
Subcellular Localization** | Lysosomes, late endosomes, secretory vesicles |
Manganese HomeostasisPrevents Mn²⁺ accumulation, which is neurotoxic at high concentrations
Zinc SignalingModulates cellular zinc homeostasis important for neuronal function
Iron MetabolismRegulates lysosomal iron storage and release to prevent iron-induced oxidative stress
Calcium RegulationContributes to lysosomal calcium signaling
KG Connections3 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (17)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
Noradrenergic-Tau Propagation Blockade
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
VCP-Mediated Autophagy Enhancement
Score: 0.59
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
APOE-Dependent Autophagy Restoration
Score: 0.89
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47

Related Analyses (30)

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Related Experiments (30)

Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40

Knowledge Graph (3 edges)

ent-gene-f7979b3d participates_in_pathway R-HSA-936837
ent-gene-f7979b3d data_in benchmark_ot_ad_answer_key:ATP13A2
benchmark_ot_ad_answer_key:ATP13A2 data_in ent-gene-f7979b3d

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