| Gene Symbol | ent-gene-7b80a607 |
| Function | 1. ULK1 inhibition: Persistent mTORC1 activity blocks ULK1 complex activation |
| mTOR promotes tau phosphorylation | Active mTORC1 enhances tau kinases (GSK3β, CDK5) |
| Tau affects mTOR signaling | Pathological tau disrupts mTOR localization and function |
| Feedback loop | Tau aggregates activate mTOR, which blocks their clearance |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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