Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Neuronal Dysfunction: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Neuronal Dysfunction |
| Key Genes/Proteins | MAPT, LCN2, Phosphorylated Tau, ALPHA-SYNUCLEIN, MISFOLDED PROTEINS |
| Related Diseases | Mood Disorders, Astrocyte A1-like Polarization |
| Related Pathways | Downregulation Of LIMK1-Cofilin Axis, Tau Phosphorylation Dysregulation |
Knowledge base pages for this entity
graph TD
Neuronal_Dysfunction["Neuronal Dysfunction"] -->|"associated"| Amyloid_beta_Pathology["Amyloid-beta Pathology"]
style Amyloid_beta_Pathology fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
MAPT["MAPT"] -->|"causes"| Neuronal_Dysfunction["Neuronal Dysfunction"]
style MAPT fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Downregulation_Of_LIMK1_Cofili["Downregulation Of LIMK1-Cofilin Axis"] -->|"contributes to"| Neuronal_Dysfunction["Neuronal Dysfunction"]
style Downregulation_Of_LIMK1_Cofili fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Phosphorylated_Tau["Phosphorylated Tau"] -->|"causes"| Neuronal_Dysfunction["Neuronal Dysfunction"]
style Phosphorylated_Tau fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
A1_like_Astrocytes["A1-like Astrocytes"] -->|"causes"| Neuronal_Dysfunction["Neuronal Dysfunction"]
style A1_like_Astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Inflammatory_Processes["Inflammatory Processes"] -->|"causes"| Neuronal_Dysfunction["Neuronal Dysfunction"]
style Inflammatory_Processes fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
style Neuronal_Dysfunction fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Mood Disorders | causes | disease | 0.85 |
| Amyloid-beta Pathology | associated_with | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MAPT | causes | protein | 0.95 |
| LCN2 | causes | gene | 0.95 |
| Tau aggregation | promotes | process | 0.92 |
| Mutant huntingtin aggregation | causes | mechanism | 0.90 |
| Downregulation Of LIMK1-Cofilin Axis | contributes_to | mechanism | 0.90 |
| Phosphorylated Tau | causes | protein | 0.90 |
| Amyloid-Beta Peptide | causes | compound | 0.90 |
| Mitochondrial Impairment | causes | process | 0.90 |
| A1-like Astrocytes | causes | cell_type | 0.89 |
| STING | contributes_to | protein | 0.85 |
| phosphatidylethanolamine metabolism | contributes_to | pathway | 0.85 |
| Inflammatory Processes | causes | process | 0.85 |
| ALPHA-SYNUCLEIN | causes | protein | 0.85 |
| MISFOLDED PROTEINS | causes | protein | 0.85 |
| DNA Damage-Induced Inflammation | contributes_to | process | 0.85 |
| Astrocyte A1-like Polarization | causes | phenotype | 0.85 |
| Impaired Autophagy | causes | process | 0.85 |
| Tau Phosphorylation Dysregulation | causes | mechanism | 0.85 |
| Glial Cell Activation | causes | process | 0.80 |
| Programmed DNA Breaks | contributes_to | process | 0.75 |
| Pesticides | causes | compound | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-07 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||