gene

STING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3522Connections

21Hypotheses

4Analyses

50Outgoing

50Incoming

2Experiments

4Debates

Summary

STING (TMEM173) is a critical innate immune sensor linking cytosolic DNA sensing to neuroinflammation in Alzheimer's, Parkinson's, and other neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	STING
Full Name	Stimulator of Interferon Genes
Aliases	TMEM173
Chromosome	5q31.2
Function	is a transmembrane protein that serves as the central signaling hub for the cGAS-STING pathway, one of the most important innate immune sensing mechanisms in eukaryotic cells.
Molecular Weight	42 kDa
Amino Acids	379 aa
Exons	6
Pathways	NF-κB
UniProt ID	Q86WV1
NCBI Gene ID	340061
Ensembl ID	ENSG00000184584
OMIM	612374
GeneCards	STING
Human Protein Atlas	STING
Associated Diseases	AD, aging, ALI, Als
Known Drugs/Compounds	2'3'-cGAMP, 2'3'-Cgamp, ADUCANUMAB, curcumin, CURCUMIN, dasatinib
Interactions	AB, ACHE, ACSL4, Actin, AD, ADAM10
KG Connections	3520 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STING — AlphaFold Q86WV1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STING["STING"] -->|"activates"| type_I_interferon["type I interferon"]
    STING["STING"] -->|"degrades"| GPX4["GPX4"]
    STING["STING"] -->|"causes"| ferroptosis["ferroptosis"]
    STING["STING"] -->|"activates"| LRRK2["LRRK2"]
    STING["STING"] -->|"produces"| type_I_interferon_1["type I interferon"]
    STING["STING"] -->|"produces"| inflammatory_cytokines["inflammatory cytokines"]
    cGAMP["cGAMP"] -->|"activates"| STING["STING"]
    substance_P["substance P"] -.->|"inhibits"| STING["STING"]
    cGAS["cGAS"] -->|"activates"| STING["STING"]
    NBR1["NBR1"] -.->|"inhibits"| STING["STING"]
    style STING fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1541)

Target	Relation	Type	Str
STING	encodes	protein	0.00
IFN	activates	protein	1.00
Senescence	activates	disease	1.00
Als	associated_with	disease	1.00
Als	regulates	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Infection	activates	disease	1.00
GENES	activates	gene	1.00
AUTOPHAGY	activates	pathway	1.00
CGAS	activates	gene	1.00
Oxidative Stress	activates	pathway	1.00
CGAS-STING	inhibits	gene	1.00
Inflammation	inhibits	disease	1.00
Als	activates	disease	1.00
Tumor	activates	disease	1.00
Carcinoma	activates	disease	1.00
Autophagy	activates	pathway	1.00
Neuroinflammation	activates	disease	1.00
Cancer	activates	disease	1.00
CGAS-STING	associated_with	gene	1.00
Als	inhibits	disease	1.00
Immune Response	activates	pathway	1.00
CGAS-STING	activates	gene	1.00
DNA	activates	gene	1.00
autophagy	activates	pathway	1.00
Inflammation	activates	disease	1.00
P62	activates	gene	1.00
Innate Immunity	activates	pathway	1.00
TBK1	activates	gene	1.00
Innate Immunity	regulates	pathway	1.00
Apoptosis	activates	pathway	1.00
CGAS-STING	therapeutic_target	gene	1.00
Autophagy	regulates	pathway	1.00
Lysosome Biogenesis	upregulates	process	0.95
Type-I Interferon Response	associated_with	process	0.95
Antitumor immunity	activates	process	0.95
interferon signaling	activates	pathway	0.95
type I interferon	promotes	process	0.95
astrocyte senescence	regulates	process	0.95
Antitumor Immunity	promotes	process	0.95
Anti-Tumor Immune Response	activates	process	0.95
Dopaminergic neurodegeneration	mediates	disease	0.95
Tumor Vasculature Remodeling	mediates	process	0.95
innate immune signaling	activates	pathway	0.95
Motor Neurons	activates	cell_type	0.95
Microglial Dysfunction	activates	process	0.95
Interferon Production	activates	process	0.95
Tumor Vasculature Remodeling	activates	process	0.95
Microglial Dysfunction	promotes	phenotype	0.95
Innate Immune System	involved_in	process	0.95

Incoming (1981)

Source	Relation	Type	Str
STING	encodes	gene	0.00
CYTOKINES	activates	gene	1.00
DSDNA	activates	gene	1.00
GPX4	activates	protein	1.00
INFLAMMATION	inhibits	gene	1.00
CGAS	targets	gene	1.00
CGAS	inhibits	gene	1.00
IRF3	activates	gene	1.00
CGAS	activates	protein	1.00
INFLAMMATION	activates	gene	1.00
TBK1	activates	gene	1.00
GENES	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
CANCER	activates	gene	1.00
MITOCHONDRIAL DNA	activates	gene	1.00
MTDNA	activates	gene	1.00
ROS	activates	gene	1.00
CGAS	regulates	gene	1.00
PYROPTOSIS	activates	gene	1.00
Ginkgetin	targets	compound	0.98
Ginkgetin	binds	compound	0.95
cGAMP	binds_to	protein	0.95
Ginkgetin	binds_to	drug	0.95
STING agonists	activates	drug	0.95
2'3'-Cgamp	activates	compound	0.95
cGAMP	activates	protein	0.95
mtDNA leakage	activates	process	0.95
SQSTM1	mediates	entity	0.95
Cgas	activates	protein	0.95
STING agonist	activates	drug	0.95
Microglia	expressed_in	cell_type	0.90
SNCA pathology	activates	process	0.90
SQSTM1	interacts_with	protein	0.90
ADSL	inhibits	gene	0.90
Alpha-Synuclein	activates	protein	0.90
cGAS	activates	protein	0.90
P62	associated_with	protein	0.90
CGAS	associated_with	gene	0.90
Ginkgetin	inhibits	compound	0.90
Autophagy	degrades	process	0.90
substance P	inhibits	protein	0.90
2'3'-cGAMP	activates	compound	0.90
Stimuli-responsive nanoplatforms	activates	compound	0.90
Familial Als-Causing Mutations	upregulates	phenotype	0.90
Stimuli-responsive Nanoplatforms	activates	compound	0.90
cytosolic ssDNA	activates	phenotype	0.90
glutamate excitotoxicity	activates	process	0.90
TRIM32	modifies	protein	0.90
p62	activates	protein	0.90
NBR1	inhibits	protein	0.90

Targeting Hypotheses (21)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Optimized Temporal Window for Metabolic Boosting Therapy Det	0.887	neurodegeneration	How do different microglial subtypes (DA
STING Antagonists as ALS Therapeutics: Drug Repurposing	0.821	neuroinflammation	How does chronic cGAS/STING activation d
cGAS-STING Pathway Hyperactivation Mediates Tau Propagation	0.760	neurodegeneration	Gap 006 analysis (archived stub)
Microglial IFN-β Priming of Motor Neuron cGAS/STING Amplific	0.720	neurodegeneration	What determines the specificity of TDP-4
TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR	0.718	alzheimers	TREM2 agonism vs antagonism in DAM micro

Plasma Claudin-5 Proteolytic Fragments Distinguish Paracellu	0.705	-	What blood-brain barrier permeability ch
cGAS-STING Senescence Circuit Disruption	0.691	neurodegeneration	Gene expression changes in aging mouse b
Chronic cGAS/STING Hyperactivation Drives Progressive Neurod	0.661	neuroinflammation	How does chronic cGAS/STING activation d
Stage-Selective TREM2 Agonism — Boosting DAM Phagocytosis in	0.637	alzheimers	TREM2 agonism vs antagonism in DAM micro
Epigenetic Bivalency at CDKN2A Locus Distinguishes Senescent	0.630	neurodegeneration	How can senescent microglia be molecular
STING Antagonism Prevents Acute-to-Chronic Neuroinflammation	0.601	neuroinflammation	What molecular mechanisms drive the tran
Astrocyte cGAS/STING Activation Converts Protective into Des	0.580	neuroinflammation	How does chronic cGAS/STING activation d
Temporal cGAS-STING Activation Stage-Specific Therapeutic Ta	0.560	neuroinflammation	How does chronic cGAS/STING activation d
HCN1-Selective Blockade Normalizes Thalamic Rebound Bursting	0.543	synaptic-biology	How do P/Q channel deficits paradoxicall
Loss of Nuclear Lamin B1 Distinguishes Senescent Microglia f	0.520	neurodegeneration	How can senescent microglia be molecular
Mitochondrial DNA Damage and cGAS-STING Activation Induces M	0.520	neurodegeneration	What molecular mechanisms drive microgli
Combinatorial PTM signatures distinguish pathological from p	0.455	neurodegeneration	Which specific post-translational modifi
Mitophagy Enhancement Blocks STING-Mediated Neuroinflammatio	0.380	neuroinflammation	Immune atlas neuroinflammation analysis
TBK1 Inhibitors as ALS Therapeutics: Targeting Downstream ST	0.380	neuroinflammation	How does chronic cGAS/STING activation d
STING-Mediated NLRP3 Inflammasome Priming in ALS Microglia	0.380	neuroinflammation	Immune atlas neuroinflammation analysis
Mitochondrial DNA Release-STING Axis as Senolytic Efficacy P	0.380	molecular-biology	What is the optimal therapeutic window t

Mentioning Analyses (4)

Scientific analyses that reference this entity

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.693

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

neuroinflammation | 2026-04-07 | 8 hypotheses Top: 0.821

What determines the specificity of TDP-43-induced mitochondrial DNA release for

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.720

Gap 006 analysis (archived stub)

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.760

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Single-cell RNA sequencing of microglial states in AD hippocampus	exploratory	Alzheimer's disease	0.850	0.00	AD mouse hippocampus	proposed	N/A
cGAS-STING Pathway Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,100,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026
Role of TREM2 in neuroinflammation. [PMID:41213496]	Abdulkhaliq AA, Alasiri G, Almoghrabi Y,	Exp Neurol	2026
Activation of stimulator of interferon genes (STING) and inhibition of vascular [PMID:41380972]	Wang Y, Hou Y, Han J, Zhang Z, Cheng Y e	J Biol Chem	2026
cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960]	Fazal F, Dar NJ, Ahamad S, Khan S, Bano	Mol Aspects Med	2026
Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397]	Lu C, Wang W, Fu YX	Nat Rev Cancer	2026
Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649]	Zhang J, St Pierre Schneider B, Muguerza	Am J Physiol Endocrinol Metab	2026
Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200]	Li D, Cui G, Yang K, Lu C, Jiang Y et al	Nat Cell Biol	2026
cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413]	Solomon J, Mandal S, Aran KR	Gene	2026
Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867]	Li L, Ye Q, Ma J, Wang Z, Liu T et al.	Cancer Cell	2026
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvir [PMID:41576929]	Mateus-Tique J, Lakshmi A, Singh B, Iyer	Cancer Cell	2026
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952]	Li X, Tang X, Zeng J, Duan L, Hou Z et a	Cell	2026
TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393]	Feiten AF, Dahm K, Schlepckow K, van Len	Nat Commun	2026
DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic [PMID:41610251]	Tomaskovic I, Prieto-Garcia C, Boskovic	Science	2026
Large-scale single-cell analysis and in silico perturbation reveal dynamic evolu [PMID:41617928]	Xia P, Shuang S, Fu D, Liu L, Yang D et	NPJ Precis Oncol	2026
Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081]	Qin H, Yang L, Du J, Xu X, Chen Z et al.	Int Immunopharmacol	2026
Dissecting genetic and immune drivers of heterogeneous responses to neoadjuvant [PMID:41720086]	Zhao Q, Huang R, Wang C, Hu J, Nie R et	Cancer Cell	2026
Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheim [PMID:41742243]	Zhang M, Lan Y, Yue Q, He J, Li L et al.	J Nanobiotechnology	2026
STING-NF-κB signaling builds an influenza spillover barrier. [PMID:41747053]	Ye R, Wang S, Hu Y, Pan Y, Zheng W et al	Science	2026
The cGAS-STING signaling pathway: A central regulator and novel therapeutic targ [PMID:41765111]	Jiang H, Ji Y, Shang T, Qi L, Li Z et al	Biochem Pharmacol	2026
cGAS-STING and PANoptosis: Interplay, Underlying Mechanisms, and Therapeutic Tar [PMID:42016387]	Wang Y, Chen J, Feng W, Li N, Zhang X et	Drug Des Devel Ther	2026

Debates (4)

Multi-agent debates referencing this entity

Analysis for knowledge gap 006 in the neurodegeneration domain.

closed · Rounds: 4 · Score: 0.79 · 2026-04-22

While the study establishes TDP-43 triggers mtDNA release via mPTP to activate c

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

The study identifies cGAS/STING activation as a consequence of TDP-43-mediated m

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

While the study demonstrates TDP-43 triggers mPTP-mediated mtDNA release, the mo

closed · Rounds: 4 · Score: 0.77 · 2026-04-21

Related Research

Hypotheses and analyses mentioning STING in their description or question text

Plasma Claudin-5 Proteolytic Fragments Distinguish Paracellular BBB Breakdown fr

Score: 0.705 · unknown disease · 2026-04-26

Claudin-5 is the most abundant tight junction protein in brain endothelial cells and is specifically degraded during ear

cGAS-STING Senescence Circuit Disruption

Score: 0.691 · neurodegeneration · 2026-04-04

## Molecular Mechanism and Rationale The cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) path

Chronic cGAS/STING Hyperactivation Drives Progressive Neurodegeneration Through

Score: 0.661 · neuroinflammation · 2026-04-21

## Mechanistic Overview Chronic cGAS/STING Hyperactivation Drives Progressive Neurodegeneration Through Sustained Type I

Stage-Selective TREM2 Agonism — Boosting DAM Phagocytosis in Early Amyloid Phase

Score: 0.637 · alzheimers · 2026-04-04

## Mechanistic Overview Stage-Selective TREM2 Agonism — Boosting DAM Phagocytosis in Early Amyloid Phase starts from the

Epigenetic Bivalency at CDKN2A Locus Distinguishes Senescent from Activated Micr

Score: 0.630 · neurodegeneration · 2026-04-22

## Mechanistic Overview Epigenetic Bivalency at CDKN2A Locus Distinguishes Senescent from Activated Microglia starts fro

STING Antagonism Prevents Acute-to-Chronic Neuroinflammation Transition via Inte

Score: 0.601 · neuroinflammation · 2026-04-15

## Mechanistic Overview STING Antagonism Prevents Acute-to-Chronic Neuroinflammation Transition via Interruption of IFN-

Astrocyte cGAS/STING Activation Converts Protective into Destructive Neuroinflam

Score: 0.580 · neuroinflammation · 2026-04-21

## Mechanistic Overview Astrocyte cGAS/STING Activation Converts Protective into Destructive Neuroinflammation starts fr

Temporal cGAS-STING Activation Stage-Specific Therapeutic Targeting

Score: 0.560 · neuroinflammation · 2026-04-21

## Mechanistic Overview Temporal cGAS-STING Activation Stage-Specific Therapeutic Targeting starts from the claim that m

HCN1-Selective Blockade Normalizes Thalamic Rebound Bursting in P/Q Channel Defi

Score: 0.543 · synaptic-biology · 2026-04-14

## Mechanistic Overview HCN1-Selective Blockade Normalizes Thalamic Rebound Bursting in P/Q Channel Deficiency starts fr

Loss of Nuclear Lamin B1 Distinguishes Senescent Microglia from Inflammatory Act

Score: 0.520 · neurodegeneration · 2026-04-22

## Mechanistic Overview Loss of Nuclear Lamin B1 Distinguishes Senescent Microglia from Inflammatory Activation starts f

Mitochondrial DNA Damage and cGAS-STING Activation Induces Microglial Senescence

Score: 0.520 · neurodegeneration · 2026-04-22

## Mechanistic Overview Mitochondrial DNA Damage and cGAS-STING Activation Induces Microglial Senescence starts from the

Combinatorial PTM signatures distinguish pathological from physiological tau sta

Score: 0.455 · neurodegeneration · 2026-04-27

A quantitative threshold of phosphorylation (S396/S404), acetylation (K280), and truncation (D421) defines a pathologica

Mitophagy Enhancement Blocks STING-Mediated Neuroinflammation in ALS

Score: 0.380 · neuroinflammation · 2026-04-27

This hypothesis proposes that targeted enhancement of mitophagy in microglia and motor neurons will prevent cytoplasmic

TBK1 Inhibitors as ALS Therapeutics: Targeting Downstream STING Signaling

Score: 0.380 · neuroinflammation · 2026-04-26

The cGAS-STING pathway drives neuroinflammation in ALS through aberrant cytoplasmic mitochondrial DNA recognition, but t

STING-Mediated NLRP3 Inflammasome Priming in ALS Microglia

Score: 0.380 · neuroinflammation · 2026-04-26

This hypothesis proposes that cytoplasmic mtDNA released from TDP-43-damaged mitochondria in ALS activates the cGAS-STIN

STING

Understanding Entity Pages

Summary

Wiki Pages (21)

STING Gene

cGAS-STING Signaling in Parkinson's Disease

cGAS-STING Pathway Dysregulation Hypothesis in Parkinson's Disease

Validated Hypothesis: STING Antagonists as ALS Therapeutics: Drug Repurposing

cGAS-STING Pathway in Neurodegeneration

cGAS-STING Inhibitors for Parkinson's Disease

cGAS-STING Cytosolic DNA Sensing Pathway in Neurodegeneration

cGAS-STING Pathway in Alzheimer's Disease

cGAS-STING Pathway and Autophagy in Neurodegeneration

cGAS-STING Inhibitor Therapy for Neurodegeneration

AD cGAS-STING and Innate Immune Pathway Companies

cGAS-STING Pathway Inhibition for Chronic Neuroinflammation

STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease

STING Inhibitor Therapy in Neurodegeneration

cGAS-STING Pathway Validation Study in Parkinson's Disease