Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
STING (TMEM173) is a critical innate immune sensor linking cytosolic DNA sensing to neuroinflammation in Alzheimer's, Parkinson's, and other neurodegenerative diseases.
| Gene Symbol | STING (TMEM173) |
| Full Name | Stimulator of Interferon Genes |
| Aliases | TMEM173 |
| Chromosome | 5q31.2 |
| Function | is a transmembrane protein that serves as the central signaling hub for the cGAS-STING pathway, one of the most important innate immune sensing mechanisms in eukaryotic cells. |
| Molecular Weight | 42 kDa |
| Amino Acids | 379 aa |
| Exons | 6 |
| Pathways | NF-κB |
| UniProt ID | Q86WV1 |
| NCBI Gene ID | 340061 |
| Ensembl ID | ENSG00000184584 |
| OMIM | 612374 |
| Encoded Protein | STING protein (379 aa) |
| Associated Diseases | AD, ALI, ALS, Aging, Alzheimer |
| Known Drugs/Compounds | MELATONIN, H-151, Ginkgetin, sevoflurane, curcumin, resveratrol |
| Interactions | PARP1, IRF3, CD68, TBK1, GPX4, CGAS |
| KG Connections | 2990 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
STING["STING"] -->|"activates"| type_I_interferon["type I interferon"]
STING["STING"] -->|"degrades"| GPX4["GPX4"]
STING["STING"] -->|"causes"| ferroptosis["ferroptosis"]
STING["STING"] -->|"activates"| LRRK2["LRRK2"]
STING["STING"] -->|"produces"| type_I_interferon_1["type I interferon"]
STING["STING"] -->|"produces"| inflammatory_cytokines["inflammatory cytokines"]
cGAMP["cGAMP"] -->|"activates"| STING["STING"]
substance_P["substance P"] -.->|"inhibits"| STING["STING"]
cGAS["cGAS"] -->|"activates"| STING["STING"]
NBR1["NBR1"] -.->|"inhibits"| STING["STING"]
style STING fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| CGAS | activates | gene | 1.00 |
| IFN | activates | protein | 1.00 |
| AUTOPHAGY | activates | pathway | 1.00 |
| Als | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| DNA | activates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| Senescence | activates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| CGAS-STING | inhibits | gene | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| CGAS-STING | activates | gene | 1.00 |
| CGAS-STING | implicated_in | gene | 1.00 |
| Infection | activates | disease | 1.00 |
| TBK1 | activates | gene | 1.00 |
| P62 | activates | gene | 1.00 |
| Innate Immunity | activates | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| CGAS-STING | associated_with | gene | 1.00 |
| CGAS-STING | therapeutic_target | gene | 1.00 |
| Innate Immunity | regulates | pathway | 1.00 |
| Type I Interferon Response | activates | process | 0.95 |
| lysosome biogenesis | promotes | process | 0.95 |
| Microglial Dysfunction | causes | process | 0.95 |
| Tumor Vasculature Remodeling | activates | process | 0.95 |
| Dopaminergic neurodegeneration | mediates | disease | 0.95 |
| GPX4 | targets | protein | 0.95 |
| Lysosome Biogenesis | upregulates | process | 0.95 |
| Tumor Vasculature Remodeling | associated_with | process | 0.95 |
| Tumor Vasculature Remodeling | mediates | process | 0.95 |
| Microglial Dysfunction | activates | process | 0.95 |
| ferroptosis | promotes | process | 0.95 |
| type I interferon signaling | activates | pathway | 0.95 |
| immune checkpoint blockade response | promotes | phenotype | 0.95 |
| cytosolic DNA sensing | regulates | process | 0.95 |
| innate immune signaling | activates | pathway | 0.95 |
| type I interferon | promotes | process | 0.95 |
| astrocyte senescence | regulates | process | 0.95 |
| neuroinflammation | promotes | process | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CGAS | activates | protein | 1.00 |
| TBK1 | activates | gene | 1.00 |
| GPX4 | activates | protein | 1.00 |
| IRF3 | activates | gene | 1.00 |
| CGAS | inhibits | gene | 1.00 |
| CGAS | therapeutic_target | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| DSDNA | activates | gene | 1.00 |
| MITOCHONDRIAL DNA | activates | gene | 1.00 |
| MTDNA | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| CGAS | regulates | gene | 1.00 |
| PYROPTOSIS | activates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| Ginkgetin | targets | compound | 0.98 |
| cGAMP | activates | protein | 0.95 |
| SQSTM1 | mediates | entity | 0.95 |
| Ginkgetin | binds | compound | 0.95 |
| Ginkgetin | binds_to | drug | 0.95 |
| mtDNA leakage | activates | process | 0.95 |
| cGAMP | binds_to | protein | 0.95 |
| Cgas | activates | protein | 0.95 |
| STING agonists | activates | drug | 0.95 |
| STING agonist | activates | drug | 0.95 |
| 2'3'-Cgamp | activates | compound | 0.95 |
| substance P | inhibits | protein | 0.90 |
| cGAS | activates | protein | 0.90 |
| NBR1 | inhibits | protein | 0.90 |
| p62 | activates | protein | 0.90 |
| TRIM32 | modifies | protein | 0.90 |
| SQSTM1 | interacts_with | protein | 0.90 |
| TDP43 | activates | entity | 0.90 |
| SNCA pathology | activates | process | 0.90 |
| Ginkgetin | inhibits | compound | 0.90 |
| STIM1 | interacts_with | protein | 0.90 |
| glutamate excitotoxicity | activates | process | 0.90 |
| cytosolic ssDNA | activates | phenotype | 0.90 |
| CGAS | upstream_of | gene | 0.90 |
| Familial Als-Causing Mutations | upregulates | phenotype | 0.90 |
| 2'3'-cGAMP | activates | compound | 0.90 |
| P62 | mediates_degradation_of | protein | 0.90 |
| Stimuli-responsive nanoplatforms | activates | compound | 0.90 |
| Stimuli-responsive Nanoplatforms | activates | compound | 0.90 |
| ADSL | inhibits | gene | 0.90 |
| Autophagy | degrades | process | 0.90 |
| Alpha-Synuclein | activates | protein | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| STING Antagonism Prevents Acute-to-Chronic Neuroinflammation | 0.605 | neuroinflammation | What molecular mechanisms drive the tran |
| HCN1-Selective Blockade Normalizes Thalamic Rebound Bursting | 0.526 | synaptic biology | How do P/Q channel deficits paradoxicall |
| cGAS-STING Senescence Circuit Disruption | 0.486 | neurodegeneration | Gene expression changes in aging mouse b |
| Stage-Selective TREM2 Agonism — Boosting DAM Phagocytosis in | 0.458 | Alzheimer's disease | TREM2 agonism vs antagonism in DAM micro |
| TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR | 0.451 | Alzheimer's disease | TREM2 agonism vs antagonism in DAM micro |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-12 | 0 hypotheses
systems biology | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960] | Fazal F, Dar NJ, Ahamad S, Khan S, Bano | Mol Aspects Med | 2026 | 0 |
| Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397] | Lu C, Wang W, Fu YX | Nat Rev Cancer | 2026 | 0 |
| Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200] | Li D, Cui G, Yang K, Lu C, Jiang Y et al | Nat Cell Biol | 2026 | 0 |
| cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413] | Solomon J, Mandal S, Aran KR | Gene | 2026 | 0 |
| Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867] | Li L, Ye Q, Ma J, Wang Z, Liu T et al. | Cancer Cell | 2026 | 0 |
| DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic [PMID:41610251] | Tomaskovic I, Prieto-Garcia C, Boskovic | Science | 2026 | 0 |
| Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081] | Qin H, Yang L, Du J, Xu X, Chen Z et al. | Int Immunopharmacol | 2026 | 0 |
| EsxN drives ISG15-mediated dsDNA release to activate cGAS-STING signaling and pr [PMID:41738749] | Zhang Q, Abudukadier A, Chen H, Xiong L, | Microbiol Spectr | 2026 | 0 |
| Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheim [PMID:41742243] | Zhang M, Lan Y, Yue Q, He J, Li L et al. | J Nanobiotechnology | 2026 | 0 |
| STING-NF-κB signaling builds an influenza spillover barrier. [PMID:41747053] | Ye R, Wang S, Hu Y, Pan Y, Zheng W et al | Science | 2026 | 0 |
| Development of UM-200: A Novel Alkyne Amide-Based Inhibitor of the cGAS-STING Pa [PMID:41866990] | Barasa L, DeOrsey L, O'Reilly MD, Choudh | J Med Chem | 2026 | 0 |
| Oxoisoaporphine Alkaloid Piano-Stool Arene Ruthenium(II) Derivative: A cGAS-STIN [PMID:41910318] | Yang LM, Lu Y, Levine MS, Wang X, Shi YQ | J Am Chem Soc | 2026 | 0 |
| African swine fever virus pE199L, as a mitophagy receptor, suppresses antiviral [PMID:41937559] | Li X, Ren B, Zhang D, Dan M, Liu D et al | Autophagy | 2026 | 0 |
| Microvesicle release drives cycles of mitophagy flux disruption and inflammatory [PMID:41941625] | Song R, Ma Y, Wan J, Hao S, Chen B et al | Proc Natl Acad Sci U S A | 2026 | 0 |
| The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213] | Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei | Neuron | 2026 | 0 |
| Role of TREM2 in neuroinflammation. [PMID:41213496] | Abdulkhaliq AA, Alasiri G, Almoghrabi Y, | Exp Neurol | 2026 | 0 |
| Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649] | Zhang J, St Pierre Schneider B, Muguerza | Am J Physiol Endocrinol Metab | 2026 | 0 |
| Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depre [PMID:41534750] | Yang X, Zhao Y, Liu W, Feng J, Wu X et a | J Ethnopharmacol | 2026 | 0 |
| Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvir [PMID:41576929] | Mateus-Tique J, Lakshmi A, Singh B, Iyer | Cancer Cell | 2026 | 0 |
| Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952] | Li X, Tang X, Zeng J, Duan L, Hou Z et a | Cell | 2026 | 0 |