concept

PERICYTE SENESCENCE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PERICYTE SENESCENCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

5Hypotheses

3Analyses

11Outgoing

16Incoming

0Experiments

10Debates

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💡 Concept Info

Name	PERICYTE SENESCENCE

Pathway Diagram

graph TD
    PERICYTE_SENESCENCE[PERICYTE SENESCENCE]
    PERICYTE_SENESCENCE -->|causes| Blood_Brain_Barrier_Dysfunctio[Blood-Brain Barrier Dysfunction]
    PERICYTE_SENESCENCE -->|causes| blood_brain_barrier_dysfunctio[blood-brain barrier dysfunction]
    PERICYTE_SENESCENCE -->|activates| glioma[glioma]
    PERICYTE_SENESCENCE -->|promotes| glioma_cell_growth[glioma cell growth]
    Autophagy[Autophagy] -->|regulates| PERICYTE_SENESCENCE
    Defective_Autophagy[Defective Autophagy] -->|causes| PERICYTE_SENESCENCE
    Rapamycin[Rapamycin] -->|treats| PERICYTE_SENESCENCE
    All_Trans_Retinoic_Acid[All-Trans Retinoic Acid] -->|inhibits| PERICYTE_SENESCENCE
    autophagy[autophagy] -->|regulates| PERICYTE_SENESCENCE
    senolytic_drugs[senolytic drugs] -->|inhibits| PERICYTE_SENESCENCE
    all_trans_retinoic_acid[all-trans retinoic acid] -.protects against.-> PERICYTE_SENESCENCE
    autophagy_activation[autophagy activation] -.prevents.-> PERICYTE_SENESCENCE

Outgoing (11)

Target	Relation	Type	Str
Blood-Brain Barrier Dysfunction	causes	phenotype	0.90
Glioma Cell Growth	associated_with	phenotype	0.78
blood-brain barrier dysfunction	causes	process	0.70
radiation-induced brain injury	associated_with	disease	0.70
glioma	activates	disease	0.70
glioma cell growth	promotes	process	0.70
BBB integrity loss	causes	phenotype	0.70
endothelial tight-junction maintenance	inhibits	process	0.70
trophic signaling	inhibits	process	0.70
BBB dysfunction	causes	phenotype	0.70
neuronal dysfunction	causes	phenotype	0.70

Incoming (16)

Source	Relation	Type	Str
Autophagy	regulates	process	0.95
Defective Autophagy	causes	process	0.92
Rapamycin	treats	drug	0.82
All-Trans Retinoic Acid	inhibits	compound	0.75
autophagy defects	causes	process	0.70
APP/Aβ	causes	gene	0.70
senolytic drugs	inhibits	drug	0.70
all-trans retinoic acid	protects_against	drug	0.70
autophagy activation	prevents	process	0.70
autophagy	regulates	process	0.70
CDKN1A	regulates	protein	0.70
senomorphic therapy	therapeutic_target_for	drug	0.70
CDKN2A	regulates	gene	0.70
amyloid-beta oligomers	causes	protein	0.50
senolytic therapy	therapeutic_target_for	drug	0.50
PDGFRB	regulates	gene	0.50

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Radiation drives pericyte senescence through lysosome acidif	0.652	neurodegeneration	What specific autophagy pathways are def
Amyloid-beta induces secondary pericyte senescence after con	0.640	neurodegeneration	Does pericyte senescence drive BBB break
Pericyte senescence is sufficient to weaken the BBB even wit	0.630	neurodegeneration	Does pericyte senescence drive BBB break
BBB leak induces secondary pericyte senescence through TGF-b	0.560	neurodegeneration	Does pericyte senescence drive BBB break
Loss of pericyte-derived pleiotrophin is a key disease-modif	0.510	neurodegeneration	Does pericyte senescence drive BBB break