Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NEUTROPHIL EXTRACELLULAR TRAPS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | NEUTROPHIL EXTRACELLULAR TRAPS |
Knowledge base pages for this entity
graph TD
NEUTROPHIL_EXTRACELLULAR_TRAPS["NEUTROPHIL EXTRACELLULAR TRAPS"]
NEUTROPHIL_EXTRACELLULAR_TRAPS -->|"expressed in"| Neutrophils["Neutrophils"]
NEUTROPHIL_EXTRACELLULAR_TRAPS -->|"activates"| NLRP3_Inflammasome["NLRP3 Inflammasome"]
NEUTROPHIL_EXTRACELLULAR_TRAPS -->|"mediates"| Sterile_Inflammatory_Liver_Inj["Sterile Inflammatory Liver Injury"]
NEUTROPHIL_EXTRACELLULAR_TRAPS -->|"causes"| Blood_Spinal_Cord_Barrier_Disr["Blood-Spinal Cord Barrier Disruption"]
NEUTROPHIL_EXTRACELLULAR_TRAPS -->|"contributes to"| Spinal_Cord_Edema["Spinal Cord Edema"]
NEUTROPHIL_EXTRACELLULAR_TRAPS -->|"mediates"| Necroptosis["Necroptosis"]
NEUTROPHIL_EXTRACELLULAR_TRAPS -->|"contributes to"| Inflammatory_Cell_Infiltration["Inflammatory Cell Infiltration"]
CD47_Blocking_Antibody["CD47-Blocking Antibody"] -->|"inhibits"| NEUTROPHIL_EXTRACELLULAR_TRAPS
Lactic_Acid["Lactic Acid"] -->|"inhibits"| NEUTROPHIL_EXTRACELLULAR_TRAPS
Spinal_Cord_Injury["Spinal Cord Injury"] -->|"causes"| NEUTROPHIL_EXTRACELLULAR_TRAPS
MMP9["MMP9"] -->|"participates in"| NEUTROPHIL_EXTRACELLULAR_TRAPS
Damage_Associated_Molecular_Pa["Damage-Associated Molecular Patterns"] -->|"activates"| NEUTROPHIL_EXTRACELLULAR_TRAPS
Citrullinated_Histone_H3["Citrullinated-Histone H3"] -.biomarker for.-> NEUTROPHIL_EXTRACELLULAR_TRAPS
Eicosapentaenoic_Acid["Eicosapentaenoic Acid"] -->|"inhibits"| NEUTROPHIL_EXTRACELLULAR_TRAPS| Target | Relation | Type | Str |
|---|---|---|---|
| Neutrophils | expressed_in | cell_type | 0.95 |
| NLRP3 Inflammasome | activates | mechanism | 0.95 |
| Sterile Inflammatory Liver Injury | mediates | disease | 0.92 |
| Blood-Spinal Cord Barrier Disruption | causes | process | 0.90 |
| Spinal Cord Edema | contributes_to | phenotype | 0.85 |
| Inflammatory Cell Infiltration | contributes_to | process | 0.85 |
| Diabetic Periodontitis | contributes_to | disease | 0.85 |
| spinal cord edema | promotes | phenotype | 0.85 |
| Necroptosis | mediates | process | 0.85 |
| Inflammatory Cell Infiltration | causes | process | 0.82 |
| Spinal Cord Edema | causes | disease | 0.80 |
| liver ischemia/reperfusion injury | exacerbates | disease | 0.80 |
| diabetic periodontitis | promotes | disease | 0.80 |
| Neuronal Death | promotes | phenotype | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CD47-Blocking Antibody | inhibits | drug | 0.95 |
| Lactic Acid | inhibits | compound | 0.95 |
| Spinal Cord Injury | causes | disease | 0.93 |
| MMP9 | participates_in | protein | 0.90 |
| Damage-Associated Molecular Patterns | activates | process | 0.90 |
| Citrullinated-Histone H3 | biomarker_for | biomarker | 0.90 |
| Eicosapentaenoic Acid | inhibits | compound | 0.90 |
| S100A8/A9 | involved_in | protein | 0.85 |
| PEPTIDYL-ARGININE-DEIMINASE 4 | involved_in | enzyme | 0.85 |
| CD47 | inhibits | gene | 0.80 |
| S100A8/A9 | associated_with | protein | 0.80 |
| CD47 | interferes_with | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||