Entity Detail โ Knowledge Graph Node
This page aggregates everything SciDEX knows about LRP8-APOER2-PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | LRP8 |
| Full Name | APOER2-PROTEIN |
| Chromosome | 1p31.3 |
| Protein Type | Receptor |
| Function | Neuronal migration: Reelin-LRP8/Dab1 signaling regulates cortical lamination |
| Amino Acids | 870 aa |
| Exons | 31 |
| Pathways | Cardiovascular Homeostasis |
| Ensembl ID | ENSG00000157193 |
| GeneCards | LRP8 |
| Human Protein Atlas | LRP8 |
| Associated Diseases | ALS, Aging, Alzheimer, Atherosclerosis, Cancer |
| Interactions | TRKB, AKT, APOA1, APOE, CYP46A1, ABCA1 |
| KG Connections | 192 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Gene expression"] --> B["LRP8 APOER2 PROTEIN"]
B --> C["Protein folding and<br/>quality control"]
B --> D["Cellular signaling"]
C --> E["Proteostasis"]
D --> F["Neurotoxicity"]
E --> G["Disease outcome"]
F --> G
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class B protein
class G disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||