gene

ABCA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1137Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

ABCA1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with AD, ALS, AMI. Connected to 280 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ABCA1
Full Name	ATP-Binding Cassette Transporter A1
Chromosome	9q31.1
Protein Type	Transporter
Target Class	Transporter
Function	is a full-size ABC transporter with a classic architecture
Mechanism of Action	Small molecule modulators to enhance cholesterol efflux and HDL formation
Primary Expression	Brain (astrocytes, microglia, neurons), liver, macrophages, intestine
Druggability	Medium (0.47)
Clinical Stage	Approved
Molecular Weight	~270 kDa
Amino Acids	2,461 amino acids
Exons	50
Pathways	Cholesterol, Epigenetic, Lipid Metabolism, Microrna, Mitochondrial Function
UniProt ID	O95477
NCBI Gene ID	19
Ensembl ID	ENSG00000165029
GeneCards	ABCA1
Human Protein Atlas	ABCA1
Associated Diseases	AD, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMI, ARM
Known Drugs/Compounds	25-Hydroxycholesterol, statins, dexamethasone, quercetin
Interactions	LDLR, SREBF2, APOE, LOX, ABCG1, P2RY12
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	HDL/apoE Particle Remodeling as a Therapeutic Swit
KG Connections	1134 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: ABCA1 — PDB 7TBJ Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ABCA1["ABCA1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    ABCA1["ABCA1"] -->|"interacts"| LDLR["LDLR"]
    ABCA1["ABCA1"] -->|"interacts"| SREBF2["SREBF2"]
    ABCA1["ABCA1"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ABCA1["ABCA1"] -->|"interacts"| Als["Als"]
    ABCA1["ABCA1"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    h_9d29bfe5["h-9d29bfe5"] -->|"targets"| ABCA1["ABCA1"]
    LDLR_1["LDLR"] -->|"interacts"| ABCA1["ABCA1"]
    SREBF2_2["SREBF2"] -->|"interacts"| ABCA1["ABCA1"]
    ACTB["ACTB"] -->|"interacts"| ABCA1["ABCA1"]
    style ABCA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (818)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Glial Lipid Accumulation	suppresses	phenotype	0.90
Tau Pathology	suppresses	phenotype	0.90
Lipid Efflux	promotes	process	0.90
APOE	co_mentioned_with	gene	0.90
Cholesterol Efflux	mediates	process	0.85
cholesterol homeostasis	participates_in	pathway	0.85
lipid efflux	regulates	process	0.85
Reverse Cholesterol Transport	participates_in	pathway	0.80
senescence	participates_in	pathway	0.80
APOE	activates	gene	0.80
Atherosclerosis	inhibits	disease	0.75
Cancer	associated_with	disease	0.75
Atherosclerosis	activates	disease	0.75
Als	activates	disease	0.75
Tumor	activates	disease	0.75
ALZHEIMER'S DISEASE	associated_with	disease	0.75
MTOR	inhibits	gene	0.70
CYP46A1	co_mentioned_with	gene	0.70
Mtor	inhibits	pathway	0.70
Cholesterol	therapeutic_target	pathway	0.70
CANCER	associated_with	gene	0.70
ATP	activates	gene	0.70
lipid metabolism	participates_in	pathway	0.70
LDL	activates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
Alzheimer's Disease	biomarker_for	disease	0.70
ROS	treats	phenotype	0.70
neural stem cells	regulates	cell_type	0.70
neurodegeneration	associated_with	disease	0.68
LDLR	interacts_with	gene	0.68
SREBF2	interacts_with	gene	0.68
ABCA7	associated_with	gene	0.65
CYP46A1	associated_with	gene	0.65
APP	associated_with	gene	0.65
HDAC3	associated_with	gene	0.65
CLU	associated_with	gene	0.65
APOE	expressed_in	gene	0.65
APOE4	expressed_in	gene	0.65
TAU	expressed_in	gene	0.65
CYP46A1	regulates	gene	0.65
astrocyte	co_discussed	concept	0.65
NLRP3	co_discussed	gene	0.65
TNF	co_discussed	gene	0.65
MTOR	co_discussed	gene	0.65
neuroinflammation	co_discussed	concept	0.65
myelin	co_discussed	concept	0.65
AQP4	co_discussed	gene	0.65
oligodendrocyte	co_discussed	concept	0.65
Als	interacts_with	disease	0.65

Incoming (319)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
TNF	downregulates	protein	0.90
h-9d29bfe5	targets_gene	hypothesis	0.90
h-64d92165	targets_gene	hypothesis	0.90
25-Hydroxycholesterol	modulates	compound	0.85
h-9d29bfe5	targets	hypothesis	0.80
SPP1	suppresses	gene	0.75
PI3K	inhibits	gene	0.70
AKT	inhibits	gene	0.70
LXRα	upregulates	transcription_factor	0.70
ABCA7	interacts_with	protein	0.70
EGFR	inhibits	gene	0.70
HDAC3	inhibits	gene	0.70
HDAC3	regulates	gene	0.70
HDAC3	treats	gene	0.70
APOE4	inhibits	gene	0.70
ROS	activates	phenotype	0.70
NEURONS	regulates	cell_type	0.70
LDLR	interacts_with	gene	0.68
SREBF2	interacts_with	gene	0.68
OSTEOBLASTS	regulates	cell_type	0.65
P2RY12	treats	gene	0.65
MACROPHAGES	inhibits	cell_type	0.65
MACROPHAGES	activates	cell_type	0.65
NLRP3 INFLAMMASOME	treats	pathway	0.65
SENESCENCE	regulates	phenotype	0.65
ISCHEMIA	activates	disease	0.65
ACTB	interacts_with	gene	0.60
P2RY12	inhibits	gene	0.60
APOA1	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
EIF4EBP1	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MTOR	inhibits	gene	0.60
ABCG1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
JUN	therapeutic_target	gene	0.60
APOE	activates	gene	0.60
LOX	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
APOE4	activates	gene	0.60
ATXN2	associated_with	gene	0.60
CACNA1A	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
FERMT2	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
CTSD	inhibits	gene	0.60
TP53	associated_with	gene	0.60
CTSB	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA	0.544	neurodegeneration	What molecular mechanisms explain how ap

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ABCA1

Understanding Entity Pages

Summary

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Therapeutics

Microglial Cells — Cell Type Hierarchy

coq10-neurodegeneration

Growth Factor Therapies

omega-3-fatty-acids-neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Coenzyme Q10 for Neurodegeneration

deferiprone-neurodegeneration

vitamin-d-therapy-neurodegeneration

Neuroprotection Strategies in Neurodegeneration

Curcumin for Neurodegeneration

Mediterranean and MIND Diets for Neurodegeneration

creatine-supplementation-neurodegeneration

Ambroxol for Neurodegeneration (GCase Chaperone Strategy)

rapamycin-tauopathy

NAD+ Precursors for Neurodegeneration

Exosome and Extracellular Vesicle Brain Delivery

tudca-udca-neurodegeneration