Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about synaptic_pruning: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| C1QA | mediates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S | 0.548 | cell biology | What is the relative contribution of con |
| TREM2 Agonism to Redirect Microglia from Synaptic Pruning to | 0.521 | neurodegeneration | How do ALS-associated OPTN mutations mec |
| Synaptic Pruning Precision Therapy | 0.465 | Alzheimer's disease | Neuroinflammation and microglial priming |
| Complement-Mediated Synaptic Pruning Dysregulation | 0.398 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
synaptic biology | 2026-04-07 | 0 hypotheses
neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.508
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-02 | 0 hypotheses
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.503
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Prolonged anesthesia induces neuroinflammation and complement-mediated microglia [PMID:36600274] | Xu F, Han L, Wang Y, Deng D, Ding Y, Zha | BMC Med | 2023 | 2 |
| Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024] | De Schepper S, Ge JZ, Sierksma A, Crowle | Nat Neurosci | 2023 | 2 |
| Young adult microglial deletion of C1q reduces engulfment of synapses and preven [PMID:41000995] | Petrisko TJ, Chu SH, Gomez-Arboledas A, | bioRxiv : the preprint server | 2025 | 1 |
| Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-med [PMID:40731189] | Zhao X, Yu J, Xu B, Xu Z, Lei X, Han S, | Alzheimer's & dementia : the j | 2025 | 1 |
| Trigeminal neuralgia. [PMID:38816415] | Ashina S, Robertson CE, Srikiatkhachorn | Nature reviews. Disease primer | 2024 | 1 |
| Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455] | Cornell J, Salinas S, Huang HY, Zhou M | Neural Regen Res | 2022 | 1 |
| The Role of Complement in Synaptic Pruning and Neurodegeneration. [PMID:34595138] | Gomez-Arboledas A, Acharya MM, Tenner AJ | ImmunoTargets and therapy | 2021 | 1 |
| Early complement genes are associated with visual system degeneration in multipl [PMID:31289819] | Fitzgerald KC, Kim K, Smith MD, Aston SA | Brain | 2019 | 1 |
| Opioid Receptors. [PMID:26332001] | Stein C | Annual review of medicine | 2016 | 1 |
| Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721] | Aranda-Abreu GE, Rojas-Durán F, Hernánde | Neurology international | 2026 | 0 |
| Sustained inhibitory dysfunction in complement component C1qa-deficient mice und [PMID:41544964] | Righes Marafiga J, Vu T, Bowlus J, Barab | Progress in neurobiology | 2026 | 0 |
| Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808] | Sanfilippo C, Castrogiovanni P, Imbesi R | GeroScience | 2026 | 0 |
| Sex-Specific Molecular Architecture of Microglia-Mediated Neuronal Pruning Acros [PMID:41324815] | Sanfilippo C, Castrogiovanni P, Imbesi R | Molecular neurobiology | 2025 | 0 |
| Proteomic discoveries in hypermobile Ehlers-Danlos syndrome reveal insights into [PMID:40972649] | Griggs M, Daylor V, Petrucci T, Weintrau | ImmunoHorizons | 2025 | 0 |
| The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and resc [PMID:39129007] | Chae S, Lee HJ, Lee HE, Kim J, Jeong YJ, | Journal of neuroinflammation | 2024 | 0 |
| Single-cell RNA sequencing reveals distinct immunology profiles in human keloid. [PMID:35990663] | ["Feng C", "Shan M", "Xia Y", "Zheng Z", | Frontiers in immunology | 2022 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Adaptive learning algorithms to optimize mobile applications for behavioral heal [PMID:33657217] | Figueroa CA, Aguilera A, Chakraborty B, | Journal of the American Medica | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| A Novel N-terminal Region to Chromodomain in CHD7 is Required for the Efficient [PMID:34161779] | Lee E, Kang C, Purhonen P, Hebert H, Bou | Journal of molecular biology | 2021 | 0 |