Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about trafficking: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| BIN1 | regulates | protein | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Lysosomal Enzyme Trafficking Correction | 0.489 | neurodegeneration | Autophagy-lysosome pathway convergence a |
| TFAM overexpression creates mitochondrial donor-recipient gr | 0.474 | neurodegeneration | Mitochondrial transfer between astrocyte |
| Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy | 0.426 | neurodegeneration | Mitochondrial transfer between neurons a |
| Palmitoylation-Targeted BACE1 Trafficking Disruptors | 0.407 | neurodegeneration | Lipid raft composition changes in synapt |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.584
cellular neuroscience | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Designed endocytosis-inducing proteins degrade targets and amplify signals. [PMID:39322662] | Huang B, Abedi M, Ahn G, Coventry B, Sap | Nature | 2025 | 1 |
| Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy t [PMID:37651673] | Deng Z, He M, Hu H, Zhang W, Zhang Y, Ge | Autophagy | 2024 | 1 |
| TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic [PMID:38783142] | Liu H, Zhen C, Xie J, Luo Z, Zeng L, Zha | Nat Cell Biol | 2024 | 1 |
| Collapse of late endosomal pH elicits a rapid Rab7 response via the V-ATPase and [PMID:38578235] | Mulligan RJ, Magaj MM, Digilio L, Redema | J Cell Sci | 2024 | 1 |
| IGF2 in memory, neurodevelopmental disorders, and neurodegenerative diseases. [PMID:37031050] | Alberini CM | Trends Neurosci | 2023 | 1 |
| Mitochondrial-derived damage-associated molecular patterns amplify neuroinflamma [PMID:35233090] | Lin MM, Liu N, Qin ZH, Wang Y | Acta Pharmacol Sin | 2022 | 1 |
| Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217] | Chang CH, Lin CH, Lane HY | Int J Mol Sci | 2021 | 1 |
| Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic [PMID:33408785] | Zhao M, Wang Y, Li L, Liu S, Wang C, Yua | Theranostics | 2021 | 1 |
| Mitochondrial DNA copy number in human disease: the more the better? [PMID:33314045] | Filograna R, Mennuni M, Alsina D, Larsso | FEBS Lett | 2021 | 1 |
| Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. [PMID:32186434] | Li C, Zhang Y, Liu J, Kang R, Klionsky D | Autophagy | 2021 | 1 |
| Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate rec [PMID:19251056] | Brown J, Jones EY, Forbes BE | Vitam Horm | 2009 | 1 |
| Blocking palmitoyl-transferase activity reduces BACE1 membrane localization and [PMID:23395894] | Unknown | Molecular Neurodegeneration | 0 | |
| Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast [PMID:41558820] | Nishioka K, Ikezaki M, Iwahashi N, Araka | Life Sci Alliance | 2026 | 0 |
| An anti-inflammatory neuroenhancer mitigates amyloid-β pathology to improve Alzh [PMID:41696149] | Fang W, Zhao J, Li L, Wang Y, Xu ZP et a | Mater Today Bio | 2026 | 0 |
| Anti-ASC antibodies alleviate Alzheimer's disease-type pathology in APP/PS1 mice [PMID:41707905] | He L, Xiaopeng Z, Juan D, Yan L | Neuroscience | 2026 | 0 |
| Intranasal administration of neural stem cell-derived extracellular vesicles pre [PMID:41923110] | Natale F, Dellaria A, Nifo Sarrapochiell | Alzheimer's research & therapy | 2026 | 0 |
| Salvianolic acid a inhibits neuroinflammation and ameliorates Alzheimer's diseas [PMID:41930874] | Xiao S, Han Y, Yan J, Wu L, Lin H et al. | Int Immunopharmacol | 2026 | 0 |
| Repurposing FDA-approved drugs as multi-target neuroprotective agents for Alzhei [PMID:41946775] | Phemphunananchai K, Waiwut P, Phetcharab | Scientific reports | 2026 | 0 |
| Nano-magnolol enhances the modulatory effects of magnolol on cognitive performan [PMID:41954680] | Youssef B, Ibrahim EA, Moselhy SS, ElShe | Discov Nano | 2026 | 0 |
| BACE-1 inhibitors as potential drug candidates for treatment of Alzheimer's dise [PMID:41966670] | Kaur N, Gupta S, Bansal G, Bansal Y | Mol Divers | 2026 | 0 |