Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about transcytosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| amyloid-beta | regulates | protein | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TFRC | involved_in | gene | 0.90 |
| caveolin_1 | enhances | protein | 0.80 |
| TfR1_clustering | activates | mechanism | 0.70 |
| LRP1 | mediates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neuropharmacology | 2026-04-13 | 2 hypotheses Top: 0.551
neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.773
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Crossing the blood-brain barrier: emerging therapeutic strategies for neurologic [PMID:39862873] | Pedder JH, Sonabend AM, Cearns MD | Lancet Neurol | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Diseas [PMID:35008731] | Unknown | International journal of molec | 2022 | 0 |
| Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Diseas [PMID:35008731] | Pluta, Januszewski, Czuczwar | International journal of molec | 2022 | 0 |
| Strategies for delivering therapeutics across the blood-brain barrier. [PMID:33649582] | Terstappen GC, Meyer AH, Bell RD | Nat Rev Drug Discov | 2021 | 0 |
| Strategies for delivering therapeutics across the blood-brain barrier. [PMID:33649582] | ["Terstappen GC", "Meyer AH", "Bell RD"] | Nat Rev Drug Discov | 2021 | 0 |
| A blood-brain barrier overview on structure, function, impairment, and biomarker [PMID:33208141] | Kadry, Noorani, Cucullo | Fluids and barriers of the CNS | 2021 | 0 |
| CD38 in Neurodegeneration and Neuroinflammation. [PMID:32085567] | Guerreiro S, Privat AL, Bressac L, Toulo | Cells | 2020 | 0 |
| Lung Endothelial Transcytosis. [PMID:32163197] | Jones JH, Minshall RD | Compr Physiol | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| A blood-brain barrier overview on structure, function, impairment, and biomarker [PMID:33208141] | Kadry H, Noorani B, Cucullo L | Fluids Barriers CNS | 2020 | 0 |
| CD38 in Neurodegeneration and Neuroinflammation. [PMID:32085567] | Guerreiro S, Privat AL, Bressac L, Toulo | Cells | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Increased brain penetration and potency of a therapeutic antibody using a monova [PMID:24411731] | Niewoehner J, Bohrmann B, Collin L | Neuron | 2014 | 0 |
| Increased brain penetration and potency of a therapeutic antibody using a monova [PMID:24411731] | ["Niewoehner J", "Bohrmann B", "Collin L | Neuron | 2014 | 0 |
| Neurodegeneration. [PMID:12938729] | Burgunder | IUBMB life | 2004 | 0 |
| Neurodegeneration. [PMID:12938729] | Unknown | IUBMB Life | 2003 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.66 · 2026-04-13
closed · Rounds: 4 · Score: 0.91 · 2026-04-06
closed · Rounds: 4 · Score: 0.94 · 2026-04-01
Hypotheses and analyses mentioning transcytosis in their description or question text
Score: 0.400 · neurodegeneration · 2026-04-29
The hypothesis proposes that pathological tau enters or spreads through the CNS via M1/M3 muscarinic receptor-mediated B
Score: 0.380 · neuropharmacology · 2026-04-27
This strategy combines LDLR upregulation-mediated cholesterol transport machinery priming with engineered endosomal esca
Score: 0.380 · neuropharmacology · 2026-04-27
This strategy combines LDLR upregulation in brain endothelial cells with engineered LRP1-targeting antibodies containing
Score: 0.357 · neurodegeneration · 2026-04-26
The same signal may be beneficial early and damaging late. Testing endothelial transcytosis with pericyte-protective dos
Score: 0.161 · molecular-biology · 2026-04-18
## Mechanistic Overview C1q-Alectinib Complexation Facilitates Brain Penetration via Receptor-Mediated Transcytosis star
Score: 0.000 · neuropharmacology · 2026-04-28
This strategy combines targeted upregulation of LDLR expression in brain endothelial cells with engineered antibodies de
Score: 0.000 · unknown disease · 2026-04-28
Combine improved BBB-penetrating anti-amyloid antibodies with selective inhibitors of P-glycoprotein and other efflux tr