protein

TFRC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TFRC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

381Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

TFRC is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Atherosclerosis. Connected to 134 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	TFRC
Full Name	Transferrin Receptor 1
Aliases	CD71, TFR1
Chromosome	3q29
Protein Type	Receptor
Target Class	Receptor
Function	Monoclonal antibodies targeting receptor or iron chelation affecting iron uptake
Mechanism of Action	Monoclonal antibodies targeting receptor or iron chelation affecting iron uptake
Druggability	Medium (0.47)
Clinical Stage	Approved
Molecular Weight	190 kDa
Amino Acids	660 aa
Pathways	Akt, Autophagy, Blood-Brain Barrier, Ferroptosis, Pi3K
UniProt ID	P02786
NCBI Gene ID	7037
Ensembl ID	ENSG00000072274
GeneCards	TFRC
Human Protein Atlas	TFRC
Associated Diseases	ALS, ALZHEIMER, Atherosclerosis, Diabetes, Inflammation
Known Drugs/Compounds	Antisense Oligonucleotides, Adeno-Associated Virus, resveratrol, rapamycin
Interactions	SLC7A11, P38, GPX4, ACSL4, GCLC, JUN
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Blood-Brain Barrier SPM Shuttle System
KG Connections	380 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: TFRC — PDB 1CX8 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TFRC["TFRC"]
    TFRC -->|"interacts"| Ms["Ms"]
    TFRC -->|"interacts"| Parkinson["Parkinson"]
    TFRC -->|"target for"| Inflammation["Inflammation"]
    TFRC -->|"activates"| Als["Als"]
    h_959a4677["h-959a4677"] -->|"target for"| TFRC
    JUN["JUN"] -->|"interacts"| TFRC
    TFR1["TFR1"] -->|"expressed in"| TFRC
    GBA1["GBA1"] -->|"interacts"| TFRC
    GENES["GENES"] -->|"interacts"| TFRC
    PI3K["PI3K"] -->|"regulates"| TFRC
    AKT["AKT"] -->|"regulates"| TFRC

Outgoing (182)

Target	Relation	Type	Str
Antisense Oligonucleotides	binds	drug	0.95
Adeno-Associated Virus	binds	compound	0.95
Transferrin Receptor 1	associated_with	protein	0.95
Transferrin Receptor 1	encodes	protein	0.95
antisense oligonucleotides	mediates	drug	0.95
Ferroptosis And Iron Metabolism	involved_in	process	0.95
Ferroptosis	biomarker_for	process	0.95
blood-brain barrier	mediates	brain_region	0.95
blood-brain barrier	associated_with	brain_region	0.95
central nervous system	associated_with	brain_region	0.92
ferroptotic cells	associated_with	cell_type	0.92
Iron Metabolism	involved_in	process	0.90
transcytosis	involved_in	process	0.90
iron metabolism	regulates	process	0.90
iron	binds	compound	0.90
iron	mediates	compound	0.90
Brain Penetration	mediates	process	0.90
Ferroptosis	involved_in	process	0.90
Iron Uptake	involved_in	process	0.85
Amyloid-Related Imaging Abnormalities	protects_against	phenotype	0.85
endocytosis	mediates	process	0.85
BACE1	co_expressed_with	protein	0.80
amyloid-beta	regulates	protein	0.80
ferroptosis	promotes	process	0.80
transferrin_receptor	encodes	protein	0.80
Als	activates	disease	0.75
Ferroptosis	associated_with	pathway	0.70
Autophagy	associated_with	pathway	0.70
Apoptosis	activates	pathway	0.70
neurodegeneration	associated_with	disease	0.66
Ms	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Parkinson	regulates	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	inhibits	disease	0.65
Diabetes	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Colorectal Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65

Incoming (199)

Source	Relation	Type	Str
h-959a4677	targets_gene	hypothesis	0.90
Chronic cerebral hypoperfusion	upregulates	process	0.85
h-959a4677	targets	hypothesis	0.80
Cadmium	upregulates	compound	0.80
JUN	interacts_with	gene	0.60
TFR1	expressed_in	gene	0.60
GBA1	interacts_with	gene	0.60
LAMP2	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
GBA1	regulates	gene	0.60
BID	associated_with	gene	0.60
PPP1CB	associated_with	gene	0.60
PI3K	regulates	gene	0.60
AKT	regulates	gene	0.60
CASP1	associated_with	gene	0.60
TFR1	regulates	gene	0.60
VEGF	associated_with	gene	0.60
JUNB	associated_with	gene	0.60
TNF	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.60
FTH1	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
JUN	associated_with	gene	0.60
JNK	associated_with	gene	0.60
P62	associated_with	gene	0.60
PIEZO1	activates	gene	0.60
BAD	degrades	entity	0.60
BID	degrades	entity	0.60
LAMP2	degrades	entity	0.60
MTOR	degrades	entity	0.60
PPP1CB	degrades	entity	0.60
GPX4	inhibits	gene	0.60
FOXO1	inhibits	gene	0.60
TAU	inhibits	gene	0.60
BAD	associated_with	gene	0.60
TLR2	therapeutic_target	gene	0.60
TLR2	associated_with	gene	0.60
BID	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60
LAMP2	metabolizes	gene	0.60
ACSL4	metabolizes	gene	0.60
PTGS2	metabolizes	gene	0.60
ACSL4	inhibits	gene	0.60
CTSD	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
ACTB	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Blood-Brain Barrier SPM Shuttle System	0.550	neurodegeneration	Neuroinflammation resolution mechanisms

Mentioning Analyses (2)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 17 hypotheses Top: 0.662

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.552

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Genome-Scale Meta-analysis of Host Responses to Staphylococcus aureus Identifies [PMID:40447280]	Russell CD, Goeldner-Thompson S, Smith E	J Infect Dis	2025	1
An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wid [PMID:38753766]	Huang Q, Chan KY, Wu J, Botticello-Romer	Science	2024	1
Targeting the transferrin receptor to transport antisense oligonucleotides acros [PMID:39141703]	Barker SJ, Thayer MB, Kim C, Tatarakis D	Sci Transl Med	2024	1
Blood-brain barrier transport using a high affinity, brain-selective VNAR antibo [PMID:33241587]	Stocki P, Szary J, Rasmussen CLM, Demydc	FASEB J	2021	1
Transferrin receptor 1 in cancer: a new sight for cancer therapy. [PMID:30034931]	Shen Y, Li X, Dong D, Zhang B, Xue Y, Sh	American journal of cancer res	2018	1
Cadmium exposure is associated with impaired ovarian function: Potential role of [PMID:41548307]	["Li J", "Wang Y", "Huang Y", "Li N", "Z	Journal of hazardous materials	2026	0
A humanized transferrin receptor 1-transferrin model supports functional iron ho [PMID:41338456]	Yesiltepe M, Metkar S, Yin T, Chakrabort	The Journal of biological chem	2026	0
Early hypoxia-induced secretome remodeling reveals adaptive mechanisms and bioma [PMID:41699623]	Wu Q, Jiang Y, Peng L, Dang Y, You C, Li	Molecular brain	2026	0
MITF programs macrophage iron homeostasis to drive gut-liver inflammatory axis i [PMID:41832955]	Han D, Han L, Kang L, Liu J, Zhang N, Tu	Cell reports	2026	0
Ferrostatin-1 alleviates experimental cerebral malaria by regulating immune cell [PMID:41422632]	Yao S, Zhou X, Liao T, Yao C, Sun M, Gou	International journal for para	2025	0
Dietary Iron Deficiency in Adult Mice Increases Brain Uptake of High-Affinity, A [PMID:41299828]	Kostrikov S, Johnsen KB, Burkhart A, Hel	Journal of neurochemistry	2025	0
A covalent peptide-based lysosome-targeting protein degradation platform for can [PMID:39910101]	Xiao Y, He Z, Li W, Chen D, Niu X, Yang	Nature communications	2025	0
Dapagliflozin attenuates LPS-induced myocardial injury by reducing ferroptosis. [PMID:38743190]	["Hu K", "Jiang P", "Hu J", "Song B", "H	Journal of bioenergetics and b	2024	0
Ferroptosis promotes valproate-induced liver steatosis in vitro and in vivo. [PMID:39147356]	["Yan X", "Ma L", "Chen X", "Ren J", "Zh	Food and chemical toxicology :	2024	0
TfR-conjugated nanoparticles achieve 50-fold increase in brain delivery vs free [PMID:synthetic_13]	Unknown	ACS Nano	2023	0
Specialized pro-resolving mediators reduce brain inflammation and amyloid pathol [PMID:synthetic_9]	Unknown	Nature Med	2023	0
TfR saturation limits uptake of targeting ligands at physiological transferrin c [PMID:synthetic_15]	Unknown	Mol Pharm	2022	0
Deficiency of pro-resolving lipid mediators in Alzheimer's disease brain and cer [PMID:synthetic_10]	Unknown	JAMA Neurol	2022	0
Resolvin D1 promotes microglial phagocytosis and suppresses inflammatory cytokin [PMID:synthetic_11]	Unknown	J Neuroinflammation	2021	0
High-dose SPM analogs cause off-target immunosuppression in sepsis models [PMID:synthetic_14]	Unknown	Crit Care Med	2021	0

TFRC

Understanding Entity Pages

Summary

Wiki Pages (21)

TFRC

Therapeutics

neuroinflammation

NRF2 Oxidative Stress Pathway

coq10-neurodegeneration

omega-3-fatty-acids-neurodegeneration

Coenzyme Q10 for Neurodegeneration

deferiprone-neurodegeneration

vitamin-d-therapy-neurodegeneration

Neuroprotection Strategies in Neurodegeneration

Curcumin for Neurodegeneration

Mediterranean and MIND Diets for Neurodegeneration

creatine-supplementation-neurodegeneration

Ambroxol for Neurodegeneration (GCase Chaperone Strategy)

NAD+ Precursors for Neurodegeneration

tudca-udca-neurodegeneration

nfl-blood-test-guided-therapy

Ferroptosis in Neurodegeneration

alpha-lipoic-acid-neurodegeneration

Iron Homeostasis Dysregulation in Neurodegeneration

aav-gene-therapy-neurodegeneration

Pathway Diagram

Outgoing (182)

Incoming (199)

Targeting Hypotheses (1)

Mentioning Analyses (2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Neuroinflammation resolution mechanisms and pro-resolving mediators

Related Papers (20)