protein

AMYLOID-BETA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYLOID-BETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1918Connections

0Hypotheses

6Analyses

50Outgoing

50Incoming

Summary

AMYLOID-BETA is a protein involved in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with ALS, Aging, Als. Connected to 542 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	AMYLOID-BETA
Protein Family	Amyloid precursor protein family
Subcellular Localization	Extracellular, membrane-associated
Molecular Weight	4.3 kDa
Amino Acids	43 aa
Pathways	Amyloid, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt ID	P05067
GeneCards	AMYLOID-BETA
Human Protein Atlas	AMYLOID-BETA
Gene	APP
PDB	1IYT, 1BA4, 2BEG, 5OQV
Mol. Weight	4 kDa (Aβ40/42)
Associated Diseases	ALS, ALZHEIMER, Aging, Alzheimer Disease
Known Drugs/Compounds	RAPAMYCIN, Lecanemab, Donanemab, Monoclonal Antibodies, Gangliosides, LRP1-Targeted Polymersomes
Interactions	AKT, AKT1, PINK1, TAU, PER, ASTROCYTES
KG Connections	1483 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure: AMYLOID-BETA — PDB 1IYT Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    AMYLOID_BETA(["AMYLOID-BETA"])
    ALZHEIMER_S_DISEASE(["ALZHEIMER'S DISEASE"])
    Alzheimer["Alzheimer"]
    Als["Als"]
    Inflammation["Inflammation"]
    ALZHEIMER(["ALZHEIMER"])
    AMYLOID(["AMYLOID"])
    APP(["APP"])

    AMYLOID_BETA -->|"associated with"| ALZHEIMER_S_DISEASE
    AMYLOID_BETA -->|"associated with"| Alzheimer
    AMYLOID_BETA -->|"therapeutic target"| Alzheimer
    AMYLOID_BETA -->|"associated with"| Als
    AMYLOID_BETA -->|"activates"| Alzheimer
    AMYLOID_BETA -->|"therapeutic target"| Als
    AMYLOID_BETA -->|"activates"| Inflammation
    AMYLOID_BETA -->|"therapeutic target"| ALZHEIMER_S_DISEASE
    ALZHEIMER -->|"associated with"| AMYLOID_BETA
    AMYLOID -->|"activates"| AMYLOID_BETA
    AMYLOID -->|"associated with"| AMYLOID_BETA
    ALZHEIMER -->|"activates"| AMYLOID_BETA
    ALZHEIMER -->|"therapeutic target"| AMYLOID_BETA
    AMYLOID_BETA -->|"associated with"| APP
    AMYLOID -.->|"inhibits"| AMYLOID_BETA

    style AMYLOID_BETA fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1123)

Target	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	gene	1.00
Alzheimer	associated_with	disease	1.00
Alzheimer	therapeutic_target	disease	1.00
Als	associated_with	disease	1.00
Alzheimer	activates	disease	1.00
Als	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
ALZHEIMER'S DISEASE	therapeutic_target	gene	1.00
APP	associated_with	gene	1.00
Alzheimer	regulates	disease	0.95
Neurodegeneration	activates	disease	0.95
Neuroinflammation	activates	disease	0.95
Apoptosis	associated_with	process	0.95
Alzheimer's Disease	associated_with	disease	0.95
Alzheimer's Disease	contributes_to	disease	0.95
Tau Aggregation	associated_with	process	0.95
Alzheimer's Disease	risk_factor_for	disease	0.95
Alzheimer's Disease	causes	disease	0.95
Astrocytes	associated_with	cell_type	0.95
Alzheimer Disease	associated_with	disease	0.95
KIF5	binds	protein	0.90
Alzheimer Disease	biomarker_for	disease	0.90
Plaque Accumulation	involved_in	process	0.90
Tau Spreading	associated_with	process	0.90
Hyperconnectivity	associated_with	phenotype	0.90
Calcium Dysregulation	causes	process	0.90
ASTROCYTES	induces_transformation_to	cell_type	0.90
ALZHEIMER'S DISEASE	activates	gene	0.90
Als	inhibits	disease	0.85
Dementia	therapeutic_target	disease	0.85
Inflammation	therapeutic_target	disease	0.85
Als	activates	disease	0.85
Neurodegeneration	therapeutic_target	disease	0.85
Aging	causes	disease	0.85
Aging	associated_with	disease	0.85
Alzheimer	inhibits	disease	0.85
Aging	therapeutic_target	disease	0.85
Neuronal Hyperactivity	associated_with	phenotype	0.85
DRP1	upregulates	protein	0.85
Calcium Homeostasis	inhibits	process	0.80
Reactive Oxygen Species	associated_with	process	0.80
CORTEX	expressed_in	brain_region	0.80
NEURODEGENERATION	causes	disease	0.80
Alzheimer's disease	causes	disease	0.80
CASP	activates	gene	0.80
AUTOPHAGY	regulates	gene	0.80
Autophagy	regulates	pathway	0.80
Oxidative Stress	therapeutic_target	pathway	0.80
NEUROINFLAMMATION	activates	gene	0.80
Als	regulates	disease	0.75

Incoming (795)

Source	Relation	Type	Str
ALZHEIMER	associated_with	gene	1.00
AMYLOID	activates	gene	1.00
AMYLOID	associated_with	gene	1.00
ALZHEIMER	activates	gene	1.00
ALZHEIMER	therapeutic_target	gene	1.00
AMYLOID	inhibits	gene	1.00
TAU	associated_with	gene	1.00
Alzheimer's Disease	associated_with	disease	0.95
BISPECIFIC ANTIBODIES	associated_with	entity	0.95
Lecanemab	targets	drug	0.90
Donanemab	targets	drug	0.90
Monoclonal Antibodies	targets	drug	0.90
Gangliosides	interacts_with	compound	0.90
LRP1-Targeted Polymersomes	treats	drug	0.90
Aducanumab	targets	drug	0.90
HSPG2	co-localizes_with	gene	0.90
BACE1	produces	protein	0.90
PSEN1	associated_with	gene	0.90
ASTROCYTES	responds_to	cell_type	0.90
NEURODEGENERATION	activates	gene	0.90
Platelets	associated_with	cell_type	0.85
Blood-Brain Barrier	regulates	cell_type	0.85
APOE2	modulates	protein	0.85
Platelets	modulates	cell_type	0.85
TREM2	mediates	protein	0.85
Ceramide	contributes_to	compound	0.85
Prp	associated_with	compound	0.80
SLC17A7	suppressed_by	gene	0.80
TET2	modulates	protein	0.80
GD3 SYNTHASE	regulates	protein	0.80
ALZHEIMER'S DISEASE	implicated_in	disease	0.80
NEURODEGENERATION	therapeutic_target	gene	0.80
AMYLOID	expressed_in	gene	0.80
ASTROCYTES	activates	gene	0.80
ALZHEIMER	inhibits	gene	0.80
ALZHEIMER	regulates	gene	0.80
AMYLOID	regulates	gene	0.80
TAU	regulates	gene	0.80
ALZHEIMER'S DISEASE	regulates	gene	0.70
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
ALZHEIMER'S DISEASE	biomarker_for	gene	0.70
GFAP	biomarker_for	gene	0.70
ALZHEIMER'S DISEASE	activates	gene	0.70
PARKINSON'S DISEASE	therapeutic_target	gene	0.70
ALZHEIMER	causes	gene	0.70
TAU	causes	gene	0.70
NEURODEGENERATION	associated_with	gene	0.70
PHAGOCYTOSIS	activates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (6)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AMYLOID-BETA

Understanding Entity Pages

Summary

Wiki Pages (21)

Amyloid-Beta (Aβ)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Pathway Diagram

Outgoing (1123)

Incoming (795)

Targeting Hypotheses (0)

Mentioning Analyses (6)

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

Extracellular vesicle biomarkers for early AD detection

Extracellular vesicle biomarkers for early AD detection

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

Lipid raft composition changes in synaptic neurodegeneration

Related Papers (0)

AMYLOID-BETA

Understanding Entity Pages

Summary

Wiki Pages (21)

Amyloid-Beta (Aβ)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

nhp-validation-animal-model

Neuroresilience Mechanisms and Evidence

NPM1 Gene

PI-2620 Tau PET in PSP

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

neuroinflammation

GRIA3 Gene

Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Mitochondrial Quality Control

Pathway Diagram

Outgoing (1123)

Incoming (795)

Targeting Hypotheses (0)

Mentioning Analyses (6)

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

Extracellular vesicle biomarkers for early AD detection

Extracellular vesicle biomarkers for early AD detection

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi

Lipid raft composition changes in synaptic neurodegeneration

Related Papers (0)