While genetic evidence links autophagy dysfunction to neurodegeneration, the debate highlighted uncertainty about causality in sporadic diseases like Alzheimer's and Parkinson's. This fundamental question determines whether autophagy restoration can modify disease progression or merely treat symptoms. Source: Debate session sess_SDA-2026-04-01-gap-011 (Analysis: SDA-2026-04-01-gap-011)
Landscape Summary: Are autophagy-lysosome defects primary drivers or downstream consequences in sporadic NDDs? is a 0.92 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: partially_addressed.
Colonna, Sevlever, et al. (TREM2 biology)
Are autophagy-lysosome defects primary drivers or downstream consequences in sporadic NDDs? — INVOKE-2 (completed)
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