gene 1,644 words KG: NFE2L2 2026-03-27
evidence:strongkind:genesection:genesstate:published
Contents

NFE2L2 — Nuclear Factor Erythroid 2-Related Factor 2

🧬 Gene Info
Gene SymbolNFE2L2
Full NameNuclear Factor Erythroid 2-Related Factor 2
Chromosome2q31
Protein FamilybZIP transcription factor family, Cap'n'collar subfamily
PathwaysAutophagy, Chaperone, Epigenetic, Ferroptosis, Glutathione Synthesis
UniProt IDQ16236
NCBI Gene ID4780
Ensembl IDENSG00000116044
OMIM604992
GeneCardsNFE2L2
Human Protein AtlasNFE2L2
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Cancer, Carcinoma, Hepatomegaly, Hepatoprotection
Known Drugs/CompoundsDimethyl Fumarate, Itaconate, Pterostilbene, dexamethasone, Quercetin, Leucocyanidin
InteractionsHMOX1, FER, C1Q, HTRA2, MTOR, SIRT3
KG Connections883 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (26)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.38
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67

Related Analyses (12)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Related Experiments (16)

Resveratrol protection against renal I/R injury in diabetic
validation · proposed · Score: 0.90
Resveratrol effects on HK-2 cells under hypoxia/reoxygenatio
exploratory · proposed · Score: 0.85
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: activates
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

NFE2L2 phosphorylates SQSTM1
NFE2L2 phosphorylates ULK1
NFE2L2 protects_against SQSTM1
NFE2L2 activates NOS3
NFE2L2 activates NR1H3
NFE2L2 activates PLIN2
NFE2L2 activates PLIN3
NFE2L2 activates PPARA
NFE2L2 activates PRKAA2
NFE2L2 activates RPTOR