| Gene Symbol | NRF2 |
| Chromosome | 2q31.2 |
| Protein Family | Cap'n'Collar (CNC) bZIP transcription factor |
| Function | Basal state: Keap1 homodimer binds NRF2 via the DLG and ETGE motifs, serving as a substrate adapter for the Cul3-RING ubiquitin E3 ligase complex. |
| Molecular Weight | 68 kDa |
| Amino Acids | 605 aa |
| Pathways | Akt, Apoptosis, Autophagy, Cell Cycle, Chaperone |
| GeneCards | NRF2 |
| Human Protein Atlas | NRF2 |
| Associated Diseases | ALS, ALZHEIMER'S DISEASE, Aging, Alzheimer |
| Known Drugs/Compounds | RAPAMYCIN, KAEMPFEROL, Ros, quercetin, 4OI, dimethyl fumarate |
| Interactions | GPX4, CX3CR1, TNF, CD163, CD68, ULK1 |
| KG Connections | 3350 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |