| Gene Symbol | NRF2 |
| Chromosome | 2q31.2 |
| Protein Family | Cap'n'Collar (CNC) bZIP transcription factor |
| Function | Basal state: Keap1 homodimer binds NRF2 via the DLG and ETGE motifs, serving as a substrate adapter for the Cul3-RING ubiquitin E3 ligase complex. |
| Molecular Weight | 68 kDa |
| Amino Acids | 605 aa |
| Pathways | Akt, Apoptosis, Autophagy, Cell Cycle, Chaperone |
| GeneCards | NRF2 |
| Human Protein Atlas | NRF2 |
| Associated Diseases | aging, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | 4-octyl itaconate, 4OI, ALGERNON2, Alpha-Tocopherol, Artesunate, ATORVASTATIN |
| Interactions | ABCG2, ACETYLCHOLINE, ACHE, ACOD1, ACSL4, Actin |
| KG Connections | 3455 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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