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Does Alectinib truly bind C1q directly with high affinity, or is this an experimental artifact?

PARTIALLY ADDRESSED

The fundamental premise remains unvalidated despite extensive mechanistic speculation. Independent validation using purified proteins and orthogonal binding assays is essential before pursuing mechanistic studies. This determines whether any C1q-related effects are direct or indirect. Source: Debate session sess_SDA-2026-04-16-gap-pubmed-20260410-095709-4e97c09e (Analysis: SDA-2026-04-16-gap-pubmed-20260410-095709-4e97c09e)

Priority: 0.90 Domain: molecular-biology Hypotheses: 0
📊 Landscape Analysis

Landscape Summary: Does Alectinib truly bind C1q directly with high affinity, or is this an experimental artifact? is a 0.9 priority gap in molecular-biology. It has 0 linked hypotheses with average composite score 0.000. Status: partially_addressed.

Key Unanswered Questions

Key Researchers

Colonna, Sevlever, et al. (TREM2 biology)

Clinical Trials

Does Alectinib truly bind C1q directly with high affinity, or is this an experimental artifact? — INVOKE-2 (completed)

📈 Living Dashboards
0
Hypotheses
0.000
Top Score
0.000
Avg Score
0
Debates
0.00
Avg Quality
60%
Resolution
0
Mechanistic Families
Gap Resolution Progress60%

Hypothesis Score Distribution

🏆 Competing Hypotheses (Ranked by Score)

No hypotheses linked to this gap yet.

🌊 Knowledge Graph Connections

activates (16)

C1q→Microglial PhagocytosisC1q→A1 reactive astrocytesC1q→Microglia-Mediated Synapse LossC1q→microglial CR3 engagementC1q→neuroinflammation
▸ Show 11 more

associated with (9)

C1q→complement-dependent phagocytosisC1q→vulnerable synapses in ADC1q→Complement activationCRP→C1qAlectinib→blood-brain barrier penetration
▸ Show 4 more

binds (1)

C1Q→Alectinib

causes (5)

C1q→SYNAPSE_ELIMINATIONC1q→synaptic dysfunctionC1q→immunosuppressionC1q→synaptic_lossAlectinib→ER stress

contributes to (1)

STAT6-MafB pathway→C1q

enhances (1)

C1q→pro-tumor inflammation

increases risk (1)

C1q→Alzheimer's_disease

inhibits (2)

TYROBP deficiency→C1qC1q→Aβ fibril formation

interact with (1)

33628204→C1q

involved in (1)

C1q→Synaptic Pruning

mediates (3)

C1q→Synaptic TaggingC1q→synaptic pruningC1q→Microglial Synaptic Elimination

produces (2)

tumor-associated macrophages→C1qmicroglia→C1q

regulates (5)

C1q→gC1qRAlectinib→blood_brain_barrierC1q→synaptic stabilityC1q→pruning of stressed neuronsC1q→M2 macrophage polarization

upregulates (2)

ABETA→C1qC1q→Glaucoma
🕑 Activity Feed
✏ update on knowledge_gap by None 2026-04-25T22:15
✏ update on knowledge_gap by None 2026-04-21T14:21
✏ update on knowledge_gap by None 2026-04-21T01:39
✏ update on knowledge_gap by None 2026-04-21T01:39
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