gene 758 words KG: P2RX4 2026-03-24
kind:genesection:genesstate:published
Contents

P2RX4 Gene

🧬 Gene Info
Gene SymbolP2RX4
Full NamePurinergic Receptor P2X 4
Chromosome12q24.31
FunctionThe P2RX4 gene encodes the P2X4 receptor subunit, which forms homomeric and heteromeric ion channels permeable to Na⁺, K⁺, and Ca²⁺.
Primary ExpressionBrain, Spinal Cord, Microglia, Astrocytes
PathwaysGlucose Homeostasis
UniProt IDQ99572
NCBI Gene ID10065
GeneCardsP2RX4
Human Protein AtlasP2RX4
Associated DiseasesALS, Inflammation, Ms, Multiple Sclerosis, glycemic traits
InteractionsP2RX7, P2RY1, P2RX5, PANX1, P2RX1, P2RY12
KG Connections101 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Purinergic Signaling Polarization Control
Score: 0.55
Microglial Purinergic Reprogramming
Score: 0.48
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.48

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90
P2RX7 variant rs1718119 association with glucose homeostasis
exploratory · proposed · Score: 0.90

See Also (10)

Packard Center for ALS Research
institution · KG edge: activates
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: expressed_in
P2RX1 Gene
gene · KG edge: activates
GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: expressed_in
CD38 Molecule (CD38)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

P2RX4 therapeutic_target P2RX7
P2RX4 therapeutic_target P2RY14
P2RX4 therapeutic_target P2RY1
P2RX4 activates P2RX7
P2RX4 associated_with CD38
P2RX4 activates P2RY1
P2RX4 activates P2RX5
P2RX4 activates PANX1
P2RX4 therapeutic_target P2RX1
P2RX4 activates P2RX1