concept

BLOOD-BRAIN BARRIER DISRUPTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BLOOD-BRAIN BARRIER DISRUPTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections
0Hypotheses
0Analyses
8Outgoing
8Incoming

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💡 Concept Info
NameBLOOD-BRAIN BARRIER DISRUPTION
Key Genes/ProteinsVEGF, MFSD2A, FUS
Related DiseasesNEUROINFLAMMATION, STROKE
Related PathwaysAMPK PATHWAY

Wiki Pages (20)

Knowledge base pages for this entity

Corticobasal Syndrome (CBS)

disease · 11374 words

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

mechanism · 7227 words

neuroinflammation

mechanism · 5462 words

Synucleinopathy Mechanism

mechanism · 4870 words

Blood-Brain Barrier Dysfunction in Neurodegeneration

mechanism · 4726 words

Pathway Diagram

graph TD
    BLOOD_BRAIN_BARRIER_DISRUPTION["BLOOD-BRAIN BARRIER DISRUPTION"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| Neuroinflammation["Neuroinflammation"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"contributes to"| Multiple_Sclerosis["Multiple Sclerosis"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| Central_Nervous_System_Damage["Central Nervous System Damage"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"causes"| Cognitive_Impairment["Cognitive Impairment"]
    BLOOD_BRAIN_BARRIER_DISRUPTION -->|"contributes to"| Neurodegenerative_Diseases["Neurodegenerative Diseases"]
    TREM1["TREM1"] -->|"mediates"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Sepsis["Sepsis"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Ischemic_Stroke["Ischemic Stroke"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Tight_Junctions["Tight Junctions"] -->|"involved_in"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Methamphetamine["Methamphetamine"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
    Stroke["Stroke"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION
    TREM1_Inhibition["TREM1 Inhibition"] -.protects against.-> BLOOD_BRAIN_BARRIER_DISRUPTION
    Hypoxia["Hypoxia"] -->|"causes"| BLOOD_BRAIN_BARRIER_DISRUPTION

Outgoing (38)

TargetRelationTypeStr
ENDOTHELIAL CELLSregulatescell_type0.65
NEUROINFLAMMATIONinhibitsphenotype0.65
PREFRONTAL CORTEXassociated_withbrain_region0.45
HIPPOCAMPUSassociated_withbrain_region0.45
CORTEXassociated_withbrain_region0.45

Incoming (43)

SourceRelationTypeStr
MICROGLIAtreatscell_type0.65
STROKEtreatsdisease0.65
VEGFregulatesgene0.65
ASTROCYTEinteracts_withcell_type0.65
STROKEinhibitsdisease0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found