| Gene Symbol | NLRP3 |
| Protein Type | Signaling Protein |
| Target Class | Signaling Protein |
| Function | In the healthy nervous system, NLRP3: - Provides innate immune surveillance - Responds to pathogen-associated molecular patterns (PAMPs) - Initiates inflammatory responses to cellular stress - Facilit |
| Mechanism of Action | Small molecule inhibitors targeting NLRP3 inflammasome assembly or activation |
| Primary Expression | Immune cells, neurons, astrocytes, microglia |
| Subcellular Localization | Cytoplasm |
| Druggability | Medium (0.51) |
| Clinical Stage | Approved |
| Molecular Weight | 118 kDa |
| Pathways | Adaptive Immunity, Ampk Signaling, Amyloid, Apoptosis, Autophagy |
| UniProt ID | Q96P20 |
| GeneCards | NLRP3 |
| Human Protein Atlas | NLRP3 |
| Protein Name | NLRP3 / NALP3 / Cryopyrin |
| Associated Diseases | AD, ALI, ALS, ALZHEIMER, Aging |
| Known Drugs/Compounds | RAPAMYCIN, METFORMIN, FINGOLIMOD, MCC950, nigericin, ruxolitinib |
| Interactions | CASP1, IL1B, PYCARD, ABCD3, FIP200, RTN3 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | NLRP3/Mitophagy Coupling Modulation |
| KG Connections | 4809 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |