The study identifies a ~0.9-Mb inversion creating two differentiated haplotypes associated with severe COVID-19, but the functional mechanisms linking this structural variant to disease severity remain unexplained. Understanding this mechanism could reveal new therapeutic targets for severe respiratory failure. Gap type: unexplained_observation Source paper: Detailed stratified GWAS analysis for severe COVID-19 in four European populations. (2022, Human molecular genetics, PMID:35848942)
Landscape Summary: How does the 17q21.31 inversion polymorphism mechanistically contribute to severe COVID-19 susceptibility? is a 0.8 priority gap in immunology. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
How does the 17q21.31 inversion polymorphism mechanistically contribute to severe COVID-19 susceptibility? — INVOKE-2 (completed)
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