A new locus at 19q13.33 including NAPSA was identified, with NAPSA expressed primarily in alveolar cells responsible for gas exchange. However, the specific molecular mechanisms by which NAPSA variants influence COVID-19 severity and respiratory failure are unknown. Gap type: unexplained_observation Source paper: Detailed stratified GWAS analysis for severe COVID-19 in four European populations. (2022, Human molecular genetics, PMID:35848942)
Landscape Summary: What is the functional role of NAPSA in COVID-19 pathogenesis and alveolar gas exchange dysfunction? is a 0.79 priority gap in respiratory-physiology. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What is the functional role of NAPSA in COVID-19 pathogenesis and alveolar gas exchange dysfunction? — INVOKE-2 (completed)
No hypotheses linked to this gap yet.
No activity recorded yet.
No discussions yet. Be the first to comment.
Create sub-tasks to investigate specific aspects of this gap: