The authors suggest tauopathy may explain brain imaging findings of atrophy in ASD/ID children, but this mechanistic link is not established. Understanding this connection is critical for interpreting neuroimaging biomarkers and developing targeted interventions for neurodevelopmental disorders. Gap type: open_question Source paper: Tauopathy in the young autistic brain: novel biomarker and therapeutic target. (None, None, PMID:32661233)
Landscape Summary: What is the causal relationship between brain atrophy seen in ASD/ID neuroimaging and underlying tauopathy? is a 0.82 priority gap in neurodevelopment. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What is the causal relationship between brain atrophy seen in ASD/ID neuroimaging and underlying tauopathy? — INVOKE-2 (completed)
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