gene

ANXIETY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANXIETY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2285Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

ANXIETY is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 520 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ANXIETY
Function	Sustained fear, anxiety, stress regulation
Category	Anxiety & Stress
Location	Forebrain, Septohypothalamic Junction
Cell Type	GABAergic neurons, Glutamatergic neurons
Neurotransmitters	GABA, Glutamate, CRF, NPY
Database	ID
Cell Ontology	CL:4042028
Taxonomy	ID
Cell Ontology (CL)	CL:4042028
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer Disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	KETAMINE
Interactions	MICROGLIA, GENES, C1QA, NEUROTOXICITY, NEUROINFLAMMATION, DEMENTIA
KG Connections	1337 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ANXIETY["ANXIETY"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    ANXIETY["ANXIETY"] -->|"activates"| Anxiety["Anxiety"]
    ANXIETY["ANXIETY"] -->|"activates"| ALS["ALS"]
    ANXIETY["ANXIETY"] -->|"activates"| Inflammation["Inflammation"]
    ANXIETY["ANXIETY"] -->|"associated"| Autism["Autism"]
    ANXIETY["ANXIETY"] -->|"associated"| Aging["Aging"]
    ASD["ASD"] -->|"causes"| ANXIETY["ANXIETY"]
    ALZHEIMER["ALZHEIMER"] -->|"co discussed"| ANXIETY["ANXIETY"]
    AMYLOID["AMYLOID"] -->|"associated"| ANXIETY["ANXIETY"]
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| ANXIETY["ANXIETY"]
    style ANXIETY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1157)

Target	Relation	Type	Str
DEPRESSION	associated_with	gene	1.00
Depression	associated_with	disease	1.00
Anxiety	associated_with	disease	1.00
Anxiety	inhibits	disease	1.00
Neurodegeneration	activates	disease	1.00
Als	activates	disease	1.00
DEPRESSION	interacts_with	disease	0.95
Anxiety	activates	disease	0.95
Oxidative Stress	activates	pathway	0.90
OXIDATIVE STRESS	activates	gene	0.90
Inflammation	activates	disease	0.85
Anxiety	causes	disease	0.85
Depression	causes	disease	0.85
Als	therapeutic_target	disease	0.85
Als	inhibits	disease	0.85
Alzheimer	activates	disease	0.85
GENES	activates	gene	0.80
DEPRESSION	causes	gene	0.80
ALZHEIMER	activates	gene	0.80
ASTROCYTES	activates	gene	0.80
ASTROCYTE	activates	gene	0.80
Neuroinflammation	activates	disease	0.75
ALS	activates	disease	0.75
Autism	associated_with	disease	0.75
Aging	associated_with	disease	0.75
Schizophrenia	associated_with	disease	0.75
Alzheimer	associated_with	disease	0.75
Dementia	inhibits	disease	0.75
Parkinson	associated_with	disease	0.75
Aging	activates	disease	0.75
Parkinson	activates	disease	0.75
Anxiety	expressed_in	disease	0.75
Depression	expressed_in	disease	0.75
Depression	activates	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Depression	inhibits	disease	0.75
Neurodegeneration	inhibits	disease	0.75
Parkinson	inhibits	disease	0.75
Depression	therapeutic_target	disease	0.75
Cardiovascular	therapeutic_target	disease	0.75
Als	associated_with	disease	0.75
Cancer	associated_with	disease	0.75
Longevity	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
CANCER	increases_risk_of	disease	0.70
MICROGLIA	activates	gene	0.70
NEUROINFLAMMATION	activates	gene	0.70
Complement	activates	pathway	0.70
DEMENTIA	inhibits	gene	0.70
CNO	inhibits	gene	0.70

Incoming (1128)

Source	Relation	Type	Str
NEURODEGENERATION	activates	gene	1.00
melatonin receptor 2	regulates	gene	0.70
NEURODEGENERATION	inhibits	gene	0.70
NEURONS	treats	cell_type	0.65
NEURONS	causes	cell_type	0.65
CORTEX	causes	brain_region	0.65
KETAMINE	interacts_with	drug	0.65
KETAMINE	targets	drug	0.65
THALAMUS	causes	brain_region	0.65
INFLAMMATION	produces	phenotype	0.65
DLG4	inhibits	gene	0.65
AMYLOID	treats	protein	0.65
GABA	produces	phenotype	0.65
OXIDATIVE STRESS	causes	phenotype	0.65
FERROPTOSIS	interacts_with	phenotype	0.65
ASD	causes	phenotype	0.64
ALZHEIMER'S	regulates	disease	0.60
ALZHEIMER	impairs	disease	0.60
ALZHEIMER'S	impairs	disease	0.60
ALZHEIMER'S DISEASE	impairs	disease	0.60
AMYGDALA	activates	brain_region	0.60
ACHE	treats	gene	0.60
CYTOKINES	destabilizes	phenotype	0.60
ALZHEIMER	co_discussed	gene	0.60
AMYLOID	associated_with	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
NF-ΚB	causes	gene	0.60
C1Q	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
GABRA1	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
APOE	associated_with	gene	0.60
PER	interacts_with	gene	0.60
GSTP1	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
CYP2E1	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
CYP1A2	associated_with	gene	0.60
COMT	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
BCHE	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ANXIETY

Understanding Entity Pages

Summary

Wiki Pages (21)

Bed Nucleus of Stria Terminalis in Anxiety

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

Pathway Diagram

Outgoing (1157)

Incoming (1128)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

What determines the selectivity of complement-mediated synaptic elimination in p

Related Papers (0)

ANXIETY

Understanding Entity Pages

Summary

Wiki Pages (21)

Bed Nucleus of Stria Terminalis in Anxiety

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

primary-progressive-aphasia

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

CBS/PSP Rehabilitation Master Guide

Corticobasal Degeneration (CBD)

nimodipine-als

Frontotemporal Dementia (FTD) Mechanistic Pathway

Multiple System Atrophy

Alzheimer's Disease

nct07165106

TREM2 Mechanism Hub

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

williams-syndrome

GSK-3β in Neurodegeneration

Mitochondrial Dysfunction in Parkinson's Disease

Pathway Diagram

Outgoing (1157)

Incoming (1128)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

What determines the selectivity of complement-mediated synaptic elimination in p

Related Papers (0)