The finding that most MOGAD patients lack detectable kappa free light chains in CSF is striking given the inflammatory nature of the disease. This suggests either fundamentally different immune compartmentalization or alternative pathogenic mechanisms that need elucidation. Gap type: unexplained_observation Source paper: Diagnostic Value of the Kappa Free Light Chain Index to Distinguish MOGAD, NMOSD, and MS. (2026, Neurology, PMID:41921124)
Landscape Summary: Why do 71% of MOGAD patients have undetectable CSF-KFLC despite active demyelination? is a 0.79 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
Why do 71% of MOGAD patients have undetectable CSF-KFLC despite active demyelination? — INVOKE-2 (completed)
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