concept

DEMYELINATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DEMYELINATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

288Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

DEMYELINATION is a concept in neurodegeneration research. Key relationships include: co discussed, associated with, causes. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 73 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DEMYELINATION
Summary	Page for Oligodendrocyte Precursor Cells in Demyelinating Disease
Key Genes/Proteins	TH, TREM2
Related Diseases	MS, REMYELINATION, NEUROINFLAMMATION

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DEMYELINATION["<b>DEMYELINATION</b>"]
    DEMYELINATION -->|"expressed in"| NEURON["NEURON"]
    DEMYELINATION -->|"expressed in"| NEURONS["NEURONS"]
    DEMYELINATION -->|"expressed in"| OLIGODENDROCYTE["OLIGODENDROCYTE"]
    DEMYELINATION -->|"expressed in"| OLIGODENDROCYTES["OLIGODENDROCYTES"]
    DEMYELINATION -->|"activates"| MICROGLIA["MICROGLIA"]
    DEMYELINATION -->|"causes"| MYELINATION["MYELINATION"]
    DEMYELINATION -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    DEMYELINATION -->|"causes"| INFLAMMATION["INFLAMMATION"]
    DEMYELINATION -->|"causes"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    MS["MS"] -->|"causes"| DEMYELINATION
    Multiple_Sclerosis["Multiple Sclerosis"] -->|"causes"| DEMYELINATION
    AQP4_Antibody_Positive_NMOSD["AQP4-Antibody-Positive NMOSD"] -->|"involved_in"| DEMYELINATION
    MOGAD["MOGAD"] -->|"involved_in"| DEMYELINATION
    Classical_Complement_Cascade["Classical Complement Cascade"] -->|"causes"| DEMYELINATION
    Astrocyte_Injury["Astrocyte Injury"] -->|"contributes to"| DEMYELINATION
    BMPR1A["BMPR1A"] -->|"causes"| DEMYELINATION
    GPX4["GPX4"] -->|"causes"| DEMYELINATION
    ASK1["ASK1"] -->|"involved_in"| DEMYELINATION
    C9ORF72DIPEPTIDEREPEATPROTEINS["C9ORF72DIPEPTIDEREPEATPROTEINS"] -->|"causes"| DEMYELINATION
    INFLAMMATION -->|"causes"| DEMYELINATION

Outgoing (100)

Target	Relation	Type	Str
NEUROMYELITIS OPTICA SPECTRUM DISORDER	involved_in	entity	0.95
MULTIPLE SCLEROSIS	involved_in	entity	0.95
MOGAD	involved_in	entity	0.95
NEURON	activates	cell_type	0.80
REMYELINATION	exacerbates	phenotype	0.70
OLIGODENDROCYTES	activates	cell_type	0.65
NEURON	associated_with	cell_type	0.65
NEURODEGENERATION	triggers	process	0.65
TREM2	causes	gene	0.65
NEUROINFLAMMATION	interacts_with	phenotype	0.65
ISCHEMIA	regulates	disease	0.65
MBP	regulates	gene	0.65
MITOCHONDRIAL DYSFUNCTION	exacerbates	phenotype	0.65
CYTOKINES	targets	phenotype	0.65
NEURONS	inhibits	cell_type	0.65
NEURODEGENERATION	protects_against	disease	0.65
NEURODEGENERATION	destabilizes	phenotype	0.60
AXL	depleted_in	gene	0.55
MYELINATION	co_discussed	entity	0.50
NEURON	co_discussed	entity	0.50
OLIGODENDROCYTE	co_discussed	entity	0.50
NEURONS	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
MS	co_discussed	entity	0.50
GFAP	co_discussed	entity	0.50
MULTIPLE SCLEROSIS	co_discussed	entity	0.50
NEURON	implicated_in	cell_type	0.50
REMYELINATION	activates	process	0.50
WHITE MATTER	activates	brain_region	0.50
COMPLEMENT CASCADE	activates	pathway	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
Cognitive Impairment	activates	phenotype	0.50
CENTRAL NERVOUS SYSTEM	interacts_with	concept	0.50
Cognitive Decline	interacts_with	disease	0.50
CENTRAL NERVOUS SYSTEM	activates	concept	0.50
GLIOSIS	activates	concept	0.50
MICROGLIAL ACTIVATION	activates	concept	0.50
RETINA	associated_with	brain_region	0.50
GRAY MATTER	associated_with	brain_region	0.45
CGAS	associated_with	gene	0.45
METFORMIN	associated_with	drug	0.45
QUERCETIN	associated_with	drug	0.45
DASATINIB	associated_with	drug	0.45
INFLAMMATION	co_discussed	process	0.40
ISCHEMIA	co_discussed	disease	0.40
NEUROINFLAMMATION	co_discussed	process	0.40
NEUROGENESIS	co_discussed	process	0.40
PHAGOCYTOSIS	co_discussed	process	0.40

Incoming (188)

Source	Relation	Type	Str
MS	causes	disease	1.00
OLIGODENDROCYTES	destabilizes	cell_type	0.70
TH	inhibits	gene	0.70
OLIGODENDROCYTE	treats	cell_type	0.70
OLIGODENDROCYTE	stabilizes	cell_type	0.70
NEUROINFLAMMATION	causes	phenotype	0.65
CHOLESTEROL	treats	phenotype	0.65
MYD88	activates	gene	0.65
PYROPTOSIS	activates	phenotype	0.65
OLIGODENDROCYTE	produces	cell_type	0.65
METFORMIN	activates	drug	0.65
ASTROCYTE	exacerbates	cell_type	0.65
ASTROCYTE	treats	cell_type	0.65
MLKL	causes	gene	0.65
ROS	causes	phenotype	0.65
ALZHEIMER'S DISEASE	interacts_with	disease	0.65
TAU	activates	protein	0.65
T CELLS	protects_against	cell_type	0.65
NLRP3	activates	gene	0.65
NLRP3 INFLAMMASOME	activates	pathway	0.65
ABCA1	causes	gene	0.65
CORPUS CALLOSUM	activates	brain_region	0.65
MULTIPLE SCLEROSIS	degrades	disease	0.65
REMYELINATION	treats	phenotype	0.65
CLU	treats	gene	0.65
TMEM106B	activates	gene	0.65
NEURON	protects_against	cell_type	0.65
AQP4	interacts_with	gene	0.65
AXL	activates	gene	0.65
AXL	regulates	gene	0.65
INFLAMMATION	causes	phenotype	0.64
OXIDATIVE_INJURY	causes	phenotype	0.64
OXPCS	causes	protein	0.64
C3	activates	protein	0.64
VANADIUM	causes	drug	0.64
APOPTOSIS	activates	process	0.58
ALS	implicated_in	disease	0.55
TREM2	expressed_in	gene	0.55
MULTIPLE SCLEROSIS	implicated_in	disease	0.55
AXL	expressed_in	gene	0.55
ASTROCYTE	co_discussed	entity	0.50
ASTROCYTES	co_discussed	entity	0.50
COMPLEMENT	co_discussed	entity	0.50
AXON	co_discussed	entity	0.50
MULTIPLE SCLEROSIS	associated_with	disease	0.50
INFLAMMATION	associated_with	process	0.50
NEURONS	associated_with	cell_type	0.50
OLIGODENDROCYTE	associated_with	cell_type	0.50
NEURONS	involved_in	cell_type	0.50
OLIGODENDROCYTES	involved_in	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DEMYELINATION

Understanding Entity Pages

Summary

Wiki Pages (21)

Oligodendrocyte Precursor Cells in Demyelinating Disease

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Corticobasal Degeneration (CBD)

NRF2 Oxidative Stress Pathway

TREM2 Mechanism Hub

Oligodendrocytes

Vascular Cognitive Impairment (VCI)

Vitamin D Signaling Pathway in Neurodegeneration

VEGF/Angiogenesis Pathway in Neurodegeneration

Spinal Cord Dorsal Horn Neurons

nlrc5-protein

Copper Dyshomeostasis in Neurodegeneration

Machado-Joseph Disease (Spinocerebellar Ataxia Type 3)

Excitotoxicity in Neurodegeneration

Glia-Neuron Crosstalk in Alzheimer's Disease

Synucleinopathies

Gemin-8 Protein