Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about nmosd: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | TREM2 |
| KG Connections | 33 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
nmosd["<b>nmosd</b>"]
AQP4["AQP4"]
nmosd -->|"associated with"| AQP4
disease["disease"]
nmosd -->|"inhibits"| disease
AQP4["AQP4"]
nmosd -->|"regulates"| AQP4
AQUAPORIN_4["AQUAPORIN-4"]
nmosd -->|"regulates"| AQUAPORIN_4
MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
nmosd -->|"associated with"| MULTIPLE_SCLEROSIS
AQP4["AQP4"]
nmosd -->|"interacts with"| AQP4
AQUAPORIN_4["AQUAPORIN-4"]
nmosd -->|"interacts with"| AQUAPORIN_4
MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
nmosd -->|"interacts with"| MULTIPLE_SCLEROSIS
Oligodendrocyte["Oligodendrocyte"]
nmosd -->|"interacts with"| Oligodendrocyte
MYELIN["MYELIN"]
nmosd -->|"interacts with"| MYELIN
disease["disease"]
nmosd -->|"interacts with"| disease
Spinal_Cord["Spinal Cord"]
nmosd -->|"interacts with"| Spinal_Cord
Autoimmune["Autoimmune"]
nmosd -->|"interacts with"| Autoimmune
AQP4["AQP4"]
nmosd -->|"activates"| AQP4
CENTRAL_NERVOUS_SYSTEM["CENTRAL NERVOUS SYSTEM"]
nmosd -->|"activates"| CENTRAL_NERVOUS_SYSTEM
microglia["microglia"]
nmosd -->|"regulates"| microglia
MYELIN["MYELIN"]
nmosd -->|"regulates"| MYELIN
DEMYELINATION["DEMYELINATION"]
nmosd -->|"regulates"| DEMYELINATION
microglia["microglia"]
nmosd -->|"activates"| microglia
Macrophage["Macrophage"]
nmosd -->|"activates"| Macrophage
MICROGLIAL_ACTIVATION["MICROGLIAL ACTIVATION"]
nmosd -->|"activates"| MICROGLIAL_ACTIVATION
microglia["microglia"]
nmosd -->|"interacts with"| microglia
mogad["mogad"]
mogad -->|"associated with"| nmosd
mogad["mogad"]
mogad -->|"interacts with"| nmosd
mogad["mogad"]
mogad -->|"regulates"| nmosd
late["late"]
late -->|"activates"| nmosd
Neuroinflammation["Neuroinflammation"]
Neuroinflammation -->|"regulates"| nmosd
TREM2["TREM2"]
TREM2 -->|"regulates"| nmosd
TREM2["TREM2"]
TREM2 -->|"activates"| nmosd
TREM2["TREM2"]
TREM2 -->|"associated with"| nmosd| Target | Relation | Type | Str |
|---|---|---|---|
| AQP4 | associated_with | gene | 0.50 |
| AQP4 | regulates | gene | 0.50 |
| AQP4 | interacts_with | gene | 0.50 |
| AQP4 | activates | gene | 0.50 |
| disease | inhibits | disease | 0.50 |
| AQUAPORIN-4 | regulates | gene | 0.50 |
| MULTIPLE SCLEROSIS | associated_with | disease | 0.50 |
| AQUAPORIN-4 | interacts_with | gene | 0.50 |
| MULTIPLE SCLEROSIS | interacts_with | disease | 0.50 |
| Oligodendrocyte | interacts_with | cell_type | 0.50 |
| MYELIN | interacts_with | concept | 0.50 |
| disease | interacts_with | disease | 0.50 |
| Spinal Cord | interacts_with | cell_type | 0.50 |
| Autoimmune | interacts_with | disease | 0.50 |
| CENTRAL NERVOUS SYSTEM | activates | concept | 0.50 |
| microglia | regulates | cell_type | 0.50 |
| MYELIN | regulates | concept | 0.50 |
| DEMYELINATION | regulates | concept | 0.50 |
| microglia | activates | cell_type | 0.50 |
| Macrophage | activates | cell_type | 0.50 |
| MICROGLIAL ACTIVATION | activates | concept | 0.50 |
| microglia | interacts_with | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| mogad | associated_with | disease | 0.50 |
| mogad | interacts_with | disease | 0.50 |
| mogad | regulates | disease | 0.50 |
| late | activates | disease | 0.50 |
| TREM2 | regulates | gene | 0.50 |
| TREM2 | activates | gene | 0.50 |
| TREM2 | associated_with | gene | 0.50 |
| TREM2 | interacts_with | gene | 0.50 |
| Neuroinflammation | regulates | process | 0.50 |
| Neuroinflammation | associated_with | process | 0.50 |
| Neuroinflammation | interacts_with | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||