gene

AQP4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AQP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1825Connections

6Hypotheses

10Analyses

50Outgoing

50Incoming

Summary

AQP4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, co discussed, activates. Associated with AD, ALI, ALS. Connected to 576 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AQP4
Chromosome	18q11.2
Protein Family	Aquaporin (AQP) family
Target Class	Ion Channel
Mechanism of Action	Water channel inhibitor or modulator
Primary Expression	Astrocytes (perivascular endfeet), Ependyma, Kidney collecting duct
Subcellular Localization	Astrocyte end-feet, perivascular, ependymal
Druggability	Low (0.35)
Clinical Stage	Phase I
Molecular Weight	34 kDa
Amino Acids	323 aa
Pathways	Adaptive Immunity, Apoptosis, Blood-Brain Barrier, Chaperone, Glymphatic Pathway
UniProt ID	P55064
Ensembl ID	ENSG00000171885
GeneCards	AQP4
Human Protein Atlas	AQP4
Associated Diseases	AD, ALI, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, ARM
Known Drugs/Compounds	TGN-020, quercetin, dasatinib, riluzole, MELATONIN
Interactions	CD19, MAX, EMD, CR2, TNF, BAX
SciDEX Target	View Target Profile (1 clinical trials)
SciDEX Hypotheses	SASP-Driven Aquaporin-4 Dysregulation Glymphatic System-Enhanced Antibody Clearance Reve Aquaporin-4 Polarization Rescue
KG Connections	1824 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure: AQP4 — PDB 7O3C Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    AQP4(["AQP4"])
    NMOSD["NMOSD"]
    Glymphatic_System("Glymphatic System")
    Central_Nervous_System["/"Central Nervous System"/"]
    Neuromyelitis_Optica_Spectrum_Disorder["Neuromyelitis Optica Spectrum Di..."]
    Glymphatic_Pathway["Glymphatic Pathway"]
    Water_Flux("Water Flux")
    Sepsis_Associated_Encephalopathy["Sepsis-Associated Encephalopathy"]
    GLYMPHATIC_SYSTEM["GLYMPHATIC SYSTEM"]
    COMPLEMENT_CASCADE["COMPLEMENT CASCADE"]
    NEUROMYELITIS_OPTICA_SPECTRUM_DISORDER["NEUROMYELITIS OPTICA SPECTRUM DI..."]
    AQP4_Ab(["AQP4-Ab"])
    Neuromyelitis_Optica["Neuromyelitis Optica"]
    Central_Nervous_System_Disorders["Central Nervous System Disorders"]

    AQP4 -->|"biomarker for"| NMOSD
    AQP4 -->|"involved in"| Glymphatic_System
    AQP4 -->|"expressed in"| Central_Nervous_System
    AQP4 -->|"biomarker for"| Neuromyelitis_Optica_Spectrum_Disorder
    AQP4 -->|"involved in"| Glymphatic_Pathway
    AQP4 -->|"mediates"| Water_Flux
    AQP4 -->|"associated with"| Sepsis_Associated_Encephalopathy
    AQP4 -->|"associated with"| Glymphatic_System
    AQP4 -->|"involved in"| GLYMPHATIC_SYSTEM
    AQP4 -->|"activates"| COMPLEMENT_CASCADE
    AQP4 -->|"associated with"| NEUROMYELITIS_OPTICA_SPECTRUM_DISORDER
    AQP4 -->|"biomarker for"| NEUROMYELITIS_OPTICA_SPECTRUM_DISORDER
    AQP4_Ab -->|"binds"| AQP4
    AQP4 -->|"associated with"| Neuromyelitis_Optica
    AQP4 -->|"associated with"| Central_Nervous_System_Disorders

    style AQP4 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1381)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
NMOSD	biomarker_for	disease	0.95
Glymphatic System	involved_in	process	0.95
Central Nervous System	expressed_in	cell_type	0.95
Neuromyelitis Optica Spectrum Disorder	biomarker_for	disease	0.95
Water Flux	mediates	process	0.95
Sepsis-Associated Encephalopathy	associated_with	disease	0.95
Glymphatic System	associated_with	process	0.95
COMPLEMENT CASCADE	activates	entity	0.95
Glymphatic System	component_of	process	0.95
Neuromyelitis Optica	biomarker_for	disease	0.95
Neuromyelitis Optica Spectrum Disorder	associated_with	disease	0.95
Aquaporin-4-IgG	binds	biomarker	0.95
Glymphatic Transport	mediates	process	0.95
Perivascular Water Transport	mediates	process	0.95
Glymphatic Dysfunction	involved_in	mechanism	0.95
Astrocytic Endfeet	expressed_in	cell_type	0.95
CSF-ISF Exchange	mediates	process	0.95
Amyloid Beta Clearance	regulates	process	0.95
Tau Clearance	regulates	process	0.95
Astrocyte Endfeet	expressed_in	cell_type	0.95
CSF-ISF Exchange	associated_with	process	0.95
Glymphatic Clearance	mediates	process	0.95
glymphatic pathway	mediates	pathway	0.95
Glymphatic Pathway	involved_in	pathway	0.95
GLYMPHATIC SYSTEM	involved_in	entity	0.95
NEUROMYELITIS OPTICA SPECTRUM DISORDER	associated_with	entity	0.95
NEUROMYELITIS OPTICA SPECTRUM DISORDER	biomarker_for	entity	0.95
Glymphatic Pathway	component_of	pathway	0.95
Neuromyelitis Optica	associated_with	disease	0.90
Central Nervous System Disorders	associated_with	disease	0.90
CHI3L1	regulates	protein	0.90
Astrocytic Autophagy	inhibits	process	0.90
Tau Aggregation	protects_against	process	0.90
BRAIN TISSUE HOMEOSTASIS	involved_in	entity	0.90
Water Transport	mediates	process	0.90
β-amyloid Transport	associated_with	process	0.90
Glymphatic Function	involved_in	process	0.90
BRAIN INTERSTITIAL SOLUTES CLEARANCE	facilitates	biological_process	0.90
CSF FLOW	facilitates	biological_process	0.90
EXTRACELLULAR TAU CLEARANCE	facilitates	biological_process	0.90
Central Nervous System Disorders	contributes_to	disease	0.90
Central Nervous System Injury	involved_in	disease	0.90
Cerebrospinal fluid influx	modulates	process	0.90
Metabolic waste clearance	mediates	process	0.90
β-amyloid clearance	mediates	process	0.90
Tau clearance	mediates	process	0.90
NF-κB Pathway	inhibits	pathway	0.90
Glymphatic Function	associated_with	process	0.90
Cerebral Edema	associated_with	phenotype	0.90

Incoming (444)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
AQP4-Ab	binds	protein	0.95
AQP4-ANTIBODY	binds	protein	0.95
IGG AUTOANTIBODY	binds	protein	0.95
TGN-020	targets	drug	0.95
TGN-020	inhibits	drug	0.90
Cecal Ligation and Perforation	upregulates	process	0.90
B cells	regulates	cell_type	0.90
B Cells	regulates	cell_type	0.90
h-c8ccbee8	targets_gene	hypothesis	0.90
h-62e56eb9	targets_gene	hypothesis	0.90
h-807d7a82	targets_gene	hypothesis	0.90
B Cells	interacts_with	cell_type	0.85
B Cells	modulates	cell_type	0.85
Estrogen	upregulates	compound	0.85
Progesterone	upregulates	compound	0.85
Testosterone	upregulates	compound	0.85
SDA-2026-04-01-gap-013	targets	analysis	0.85
Plasmablast/Plasma Cell	associated_with	cell_type	0.85
h-c8ccbee8	targets	hypothesis	0.80
h-62e56eb9	targets	hypothesis	0.80
h-807d7a82	targets	hypothesis	0.80
MMP9	inhibits	gene	0.80
B Cells	associated_with	cell_type	0.80
GFAP	co-regulated_with	protein	0.80
P38MAPK	regulates	pathway	0.80
TDP-43	downregulates	protein	0.80
AQP1	co_mentioned_with	gene	0.80
BHB	regulates	compound	0.80
Musk	downregulates	drug	0.80
TMAO	downregulates	drug	0.80
MTNR1A	regulates_expression	gene	0.80
TNF	downregulates	gene	0.80
IL1B	downregulates	gene	0.80
Microglia	involved_in	cell_type	0.75
Reactive Astrogliosis	modulates	process	0.75
RILUZOLE	causes	drug	0.70
GABA	causes	phenotype	0.70
SENESCENCE	stabilizes	phenotype	0.70
MELATONIN	activates	drug	0.70
MELATONIN	regulates	drug	0.70
ALZHEIMER'S DISEASE	causes	disease	0.70
CSF	activates	phenotype	0.65
TH	interacts_with	gene	0.65
ABCA1	co_discussed	gene	0.65
GLYMPHATIC CLEARANCE	interacts_with	phenotype	0.65
ALPHA-SYNUCLEIN	associated_with	concept	0.65
ASTROCYTE	targets	cell_type	0.65
ASTROCYTE	treats	cell_type	0.65
GLIOSIS	inhibits	phenotype	0.65

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.612	neuroinflammation	How do B cells mechanistically orchestra
IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral	0.601	neuroinflammation	How do B cells mechanistically orchestra
SASP-Driven Aquaporin-4 Dysregulation	0.590	neurodegeneration	Senolytic therapy for age-related neurod
Glymphatic System-Enhanced Antibody Clearance Reversal	0.537	neurodegeneration	Blood-brain barrier transport mechanisms
Aquaporin-4 Polarization Rescue	0.507	neurodegeneration	4R-tau strain-specific spreading pattern

TREM2-Dependent Microglial Surveillance Controls AQP4-Mediat	0.452	neuroscience	Circuit-level neural dynamics in neurode

Mentioning Analyses (10)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Aquaporin-4 in glymphatic system, and its implication for central nervous system [PMID:36796590]	Peng S, Liu J, Liang C, Yang L, Wang G	Neurobiol Dis	2023	2
Uncommon inflammatory/immune-related myelopathies. [PMID:34715593]	Valencia-Sanchez C, Flanagan EP	J Neuroimmunol	2021	2
Characteristics of MRI lesions in AQP4 antibody-positive NMOSD, MOGAD, and multi [PMID:40773034]	Leitner U, Chew SH, Blanch J, Viswanatha	J Neurol	2025	1
B cell and aquaporin-4 antibody relationships with neuromyelitis optica spectrum [PMID:39222408]	Bennett JL, Pittock SJ, Paul F, Kim HJ,	Ann Clin Transl Neurol	2024	1
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. [PMID:38383779]	Afzali AM, Nirschl L, Sie C, Pfaller M,	Nature	2024	1
Neuromyelitis optica spectrum disorders: from pathophysiology to therapeutic str [PMID:34530847]	Carnero Contentti E, Correale J	J Neuroinflammation	2021	1
Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressu [PMID:31959516]	Reeves BC, Karimy JK, Kundishora AJ, Mes	Trends Mol Med	2020	1
Inebilizumab-cdon. [PMID:32936251]	Unknown	American journal of health-sys	2020	1
The glymphatic pathway in neurological disorders. [PMID:30353860]	Rasmussen MK, Mestre H, Nedergaard M	Lancet Neurol	2018	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Ganglion Cell Layer Compared With Inner Plexiform Layer Atrophy After Optic Neur [PMID:41881459]	Filippatou AG, Gakis G, Bacchetti A, Kim	Neurology(R) neuroimmunology &	2026	0
β-Hydroxybutyrate improves glymphatic system function and alleviates cerebral ed [PMID:41535708]	Yu MJ, Xiong RQ, Wu JW, Li YC, Xie JX et	Acta Pharmacol Sin	2026	0
CCR2 knockdown attenuates post-hemorrhagic hydrocephalus and improves glymphatic [PMID:41539459]	Deng H, Zhang S, Wang H, Liu X, Zhong K	Exp Neurol	2026	0
Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis opt [PMID:41665955]	Qi F, Lennon VA, Zhao S, Guo Y, Ding H e	J Clin Invest	2026	0
Safety and efficacy of ravulizumab in patients with NMOSD previously treated wit [PMID:41782198]	Bennett JL, Bhattacharyya S, Zabeti A, L	Mult Scler	2026	0
NMOSD and MOGAD: Updates on diagnostic criteria. [PMID:41927386]	Marignier R, Leal Rato M	Rev Neurol (Paris)	2026	0
Therapeutic updates in NMOSD and MOGAD: From present practice to future promise. [PMID:41927387]	Elosua-Bayés I, Cobo-Calvo A	Rev Neurol (Paris)	2026	0
Psychiatric comorbidities cluster early after onset in MOGAD: a cross-sectional [PMID:41956817]	Niederschweiberer M, Bakir C, Vorasoot N	J Neurol Neurosurg Psychiatry	2026	0
Astrocyte-related proteins mediate the association of YWHAG with Alzheimer's pat [PMID:41957344]	Zhang Z, Huang P, Yang Y, Wu H, Yao X et	Transl Psychiatry	2026	0
Understanding Further the Phenotypic Spectrum of Central Nervous System Inflamma [PMID:41957957]	Gulec B, Everest E, Tutuncu M, Bilge U,	Ann Clin Transl Neurol	2026	0

AQP4

Understanding Entity Pages

Summary

Wiki Pages (21)

AQP4 (Aquaporin-4 Gene)

cbs-psp-daily-action-plan

Sleep and Circadian Dysfunction in Alzheimer's Disease

CBS/PSP Supplements Guide

calcium-dysregulation-comparison

neuroinflammation

Pathway Diagram

Outgoing (1381)

Incoming (444)

Targeting Hypotheses (6)

Mentioning Analyses (10)

How do B cells mechanistically orchestrate tolerance to AQP4 and prevent autoimm

What are the specific molecular mechanisms by which AQP4 dysfunction contributes

How can AQP4 be effectively targeted therapeutically to improve neurological out

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

Sleep disruption as cause and consequence of neurodegeneration

Perivascular spaces and glymphatic clearance failure in AD

Senolytic therapy for age-related neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

4R-tau strain-specific spreading patterns in PSP vs CBD

Blood-brain barrier transport mechanisms for antibody therapeutics

Related Papers (20)

AQP4

Understanding Entity Pages

Summary

Wiki Pages (21)

AQP4 (Aquaporin-4 Gene)

cbs-psp-daily-action-plan

Sleep and Circadian Dysfunction in Alzheimer's Disease

CBS/PSP Supplements Guide

calcium-dysregulation-comparison

neuroinflammation

Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

Astrocyte Reactivity Mechanism

Circadian Rhythm in Neurodegeneration

Blood-Brain Barrier Dysfunction in Neurodegeneration

Vascular Cognitive Impairment (VCI)

Blood-Brain Barrier Biology and Crossing Strategies

blood-brain-barrier

cognitive-reserve-cbs-psp

Glia-Neuron Crosstalk in Alzheimer's Disease

Astrocytes

Idorsia Pharmaceuticals Ltd.

neurovascular-coupling

Multiple Sclerosis (MS)

neurovascular-dysfunction

Pathway Diagram

Outgoing (1381)

Incoming (444)

Targeting Hypotheses (6)

Mentioning Analyses (10)

How do B cells mechanistically orchestrate tolerance to AQP4 and prevent autoimm

What are the specific molecular mechanisms by which AQP4 dysfunction contributes

How can AQP4 be effectively targeted therapeutically to improve neurological out

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

Sleep disruption as cause and consequence of neurodegeneration

Perivascular spaces and glymphatic clearance failure in AD

Senolytic therapy for age-related neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

4R-tau strain-specific spreading patterns in PSP vs CBD

Blood-brain barrier transport mechanisms for antibody therapeutics

Related Papers (20)