APOE4 lipid dysregulation and synaptic phagocytosis as early drivers of AD pathology requires proximal validation

graph TD
    APOE4["APOE4"] -->|causes| lipid_dysregulation["lipid dysregulation"]
    APOE4_1["APOE4"] -->|causes| synaptic_phagocytosis["synaptic phagocytosis"]
    APOE4_2["APOE4"] -->|risk factor for| AD["AD"]
    APOE4_to_APOE3_correction["APOE4 to APOE3 correction"] -->|prevents| amyloid["amyloid"]
    APOE4_to_APOE3_correction_3["APOE4 to APOE3 correction"] -->|modulates| synaptic_function["synaptic function"]
    APOE_genotype["APOE genotype"] -->|associated with| AD_4["AD"]
    neuron_microglia_astrocyt["neuron-microglia-astrocyte co-culture validation"] -->|regulates| APOE4_synaptic_causality["APOE4 synaptic causality"]
    APOE4_5["APOE4"] -->|causes| amyloid_6["amyloid"]
    sess_AD_MASTER_PLAN_APOE_["sess_AD-MASTER-PLAN-APOE-20260428030754_task_66f1207e_ctx"] -->|causal extracted| processed["processed"]
    style APOE4 fill:#ce93d8,stroke:#333,color:#000
    style lipid_dysregulation fill:#4fc3f7,stroke:#333,color:#000
    style APOE4_1 fill:#ce93d8,stroke:#333,color:#000
    style synaptic_phagocytosis fill:#4fc3f7,stroke:#333,color:#000
    style APOE4_2 fill:#ce93d8,stroke:#333,color:#000
    style AD fill:#ef5350,stroke:#333,color:#000
    style APOE4_to_APOE3_correction fill:#4fc3f7,stroke:#333,color:#000
    style amyloid fill:#4fc3f7,stroke:#333,color:#000
    style APOE4_to_APOE3_correction_3 fill:#4fc3f7,stroke:#333,color:#000
    style synaptic_function fill:#4fc3f7,stroke:#333,color:#000
    style APOE_genotype fill:#ce93d8,stroke:#333,color:#000
    style AD_4 fill:#ef5350,stroke:#333,color:#000
    style neuron_microglia_astrocyt fill:#4fc3f7,stroke:#333,color:#000
    style APOE4_synaptic_causality fill:#4fc3f7,stroke:#333,color:#000
    style APOE4_5 fill:#ce93d8,stroke:#333,color:#000
    style amyloid_6 fill:#4fc3f7,stroke:#333,color:#000
    style sess_AD_MASTER_PLAN_APOE_ fill:#4fc3f7,stroke:#333,color:#000
    style processed fill:#4fc3f7,stroke:#333,color:#000