ID: h-5779a65ad4
Hypothesis
Cell-state stratification is required to resolve DPP6 GWAS Signal: Cell-Type Regulatory Networks for PD Cognitive Decline
The question is likely underpowered or misleading unless analyses preserve the key strata: DPP6, GWAS.
EvidencePending (0%)📖 0 cit🗣 1 debates✓ 1 support✗ 1 oppose
✓ All Quality Gates Passed
🧪 Overview
The question is likely underpowered or misleading unless analyses preserve the key strata: DPP6, GWAS. Averaging across these strata could convert a causal subpopulation effect into a weak association.
🧬 Mechanism
🧬 Curated Mechanism Pathway
Curated pathway from expert analysis
flowchart TD
A["DPP6 GWAS Signal<br/>PD Cognitive Risk Locus"]
B["Neuronal Potassium Channel States<br/>K+ Current Properties in Subtypes"]
C["Synaptic Excitability Regulation<br/>Dendritic Integration State"]
D["Cognitive Resilience Mechanism<br/>Executive Function Preservation"]
E["Cell-State Stratification<br/>Vulnerable vs Resilient Neuronal Populations"]
F["PD Cognitive Preservation<br/>Targeted DPP6 Modulation Strategy"]
A --> B
B --> C
C --> D
D --> E
E --> F
style A fill:#1b5e20,stroke:#a5d6a7,color:#a5d6a7
style F fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9a⚖️ Evidence
⚖️ Evidence Matrix1 supports1 contradicts
Supports
The open question explicitly depends on cell-type, region, or molecular-state resolution.
Contradicts
Stratified effects may reflect sampling or annotation artifacts rather than mechanism.
📖 Linked Papers
No linked papers recorded for this hypothesis yet.
🏥 Translation
🧬 3D Protein Structure — GWAS
No curated PDB or AlphaFold mapping for GWAS yet. Search RCSB →
💉 Clinical Trials
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for GWAS.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
🏆 Tournament
🏆 Arenas / Elo
No arena matches recorded yet. Browse Arenas →
📊 Market Indicators
7d Trend
↔
Stable
7d Momentum
▼ 0.4%
Volatility
Low
0.0016
Events (7d)
2
Price History
▼8.8%💾 Resource Usage
LLM Tokens
319,401
$1.0465
API Calls
201
Total Cost
$1.0465
▸Metadatasource: v1_phase_c_backfill · origin_type: debate_synthesizer
| source | v1_phase_c_backfill |
| origin_type | debate_synthesizer |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.