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The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis: A Systematic Review of In Vitro, In Vivo, and In Silico Studies.
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ID: paper-41833023
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The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis: A Systematic Review of In Vitro, In Vivo, and In Silico Studies.
Osmanlioglu Dag SR, Tatli Cankaya II, Ozkan AMG
Abstract
Artemisinin (ART), a sesquiterpene lactone derived from Artemisia annua L., and its semisynthetic derivatives such as dihydroartemisinin (DHA) and artesunate (ARTE) have gained significant attention for their anticancer potential beyond their established antimalarial effects. The antitumor activity is mediated by various mechanisms, with ferroptosis-an iron-dependent, non-apoptotic form of cell death characterized by lipid peroxidation-standing out as a key pathway. Recent in vitro, in vivo, and...
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📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
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Incoming
1
Outgoing
1
0 supporting
0 contradicting
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