O-GlcNAc Modification Orchestrates HUWE1-Mediated Ubiquitination of TfR1 to Regulate Ferroptosis and Trophoblast Syncytialization in Preeclampsia.

Trophoblast stress may be one of the etiologies of the pathology of the placenta in preeclampsia (PE). During pregnancy, females experience a substantial increase in iron requirements. Paradoxically, excessive iron intake or elevated iron levels can pose risks to pregnancy and contribute to reproductive disorders. Labile iron, owing to its oxidative and toxic properties, triggers cellular oxidative stress and initiates ferroptosis. O-GlcNAc modification has been linked to ferroptosis in recent s...