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Figure 3 — Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyel
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Created: 2026-04-21T18:29:40
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Figure 3Figure 3
Modelled kinetics of granulocyte activation markers (GAM) in CSF over 60 days following disease exacerbation . Modelled CSF levels of neutrophil elastase (nEla), myeloperoxidase (MPO), matrix metalloproteinase-8 (MMP-8) and neutrophil gelatinase-associated lipocalin (NGAL) are shown for neuromyelitis optica spectrum disorder (NMOSD) (orange line), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) (blue line) and multiple sclerosis (MS) (red line). The x -axis represents days post-exacerbation (0–60 days), with the vertical dashed line marking the transition from the acute (≤21 days) to the subacute/chronic stage (>21 days). Biomarker values ( y -axis) are plotted in pg/ml on a log-transformed scale. Solid lines represent modelled trajectories, with shaded areas denoting 95% confidence intervals. Distinct kinetic patterns are observed: Pattern 1 (nEla, MPO, MMP-8) shows early elevation in MOGAD and NMOSD but relative stability in MS; Pattern 2 (NGAL) shows early e
▸Metadata
| pmid | paper-40988129 |
| caption | Modelled kinetics of granulocyte activation markers (GAM) in CSF over 60 days following disease exacerbation . Modelled CSF levels of neutrophil elastase (nEla), myeloperoxidase (MPO), matrix metallop |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC13058455/bin/awaf345f3.jpg |
| paper_title | Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyelitis optica from multiple sclerosis. |
| figure_label | Figure 3 |
| figure_number | 3 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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