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Figure 3 — Small nucleoli are a cellular hallmark of longevity.
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Created: 2026-04-21T18:29:40
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ID: paper-fig-paper-5839e7d0e39b-3
Figure 3Figure 3
Longevity mutants have reduced ribosome biogenesis. ( a ) FIB-1::GFP is strongly down-regulated in eat-2(ad465) animals but up-regulated in ncl-1(e1942) and eat-2;ncl-1 double mutants (20 worms imaged per replicate, 3 independent biological replicates). ( b – d ) rRNA, RPS6, RPS15 and FIB-1 levels are increased in ncl-1(e1942) and reduced in eat-2(ad465) , isp-1(qm150) , glp-1(e2141) , daf-2 RNAi and TOR RNAi and this effect is partially reversed by the loss of ncl-1. daf-2(e1370) also shows reduced rRNA levels compared to daf-2;daf-16(mu86) (Error bars represent mean±s.e.m.). ( e ) fib-1 RNAi extends lifespan of N2 ( P =0.0004, log-rank test, three independent biological replicates) ( f ) fib-1 RNAi reduces the nucleolar size of N2 (Error bars represent mean±s.d.). Scale bar represents 20 μm. * P <0.05, ** P <0.01, **** P <0.0001, unpaired t -test.
▸Metadata
| pmid | paper-5839e7d0e39b |
| caption | Longevity mutants have reduced ribosome biogenesis. ( a ) FIB-1::GFP is strongly down-regulated in eat-2(ad465) animals but up-regulated in ncl-1(e1942) and eat-2;ncl-1 double mutants (20 worms |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC5582349/bin/ncomms16083-f3.jpg |
| paper_title | Small nucleoli are a cellular hallmark of longevity. |
| figure_label | Figure 3 |
| figure_number | 3 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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