| ch-5841194d8598e63ca | Resolve: TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzh | open | $1,000 | 0.82 | 2026-04-26 | single_hypothesis | hypothesis_resolve |
| ch-8f5f0ae54191 | Resolve: Dual-Receptor Antibody Shuttling | open | $2,046 | 0.80 | 2026-04-26 | single_hypothesis | experimental_verification |
| ch-594c7c68f61c | Resolve: Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction | open | $3,725 | 0.92 | 2026-04-26 | single_hypothesis | experimental_verification |
| ch-c9dec1edc49b | Resolve: Elevated CSF/Serum Albumin Quotient Predicts Neurodegeneration Progress | open | $2,375 | 0.82 | 2026-04-26 | single_hypothesis | experimental_verification |
| ch-91aebb2af05f | Resolve: Ketone Utilization Index as Metabolic Flexibility Biomarker | open | $2,281 | 0.82 | 2026-04-26 | single_hypothesis | experimental_verification |
| ch-f818c3137cfe | Resolve: LRP1-Dependent Tau Uptake Disruption | open | $2,127 | 0.81 | 2026-04-26 | single_hypothesis | experimental_verification |
| ch-f9b8bdb56210 | Resolve: Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Release Mecha | open | $2,060 | 0.80 | 2026-04-26 | single_hypothesis | experimental_verification |
| ch-d5040cc6d8cb | Resolve: Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neurodegenerat | open | $2,045 | 0.80 | 2026-04-26 | single_hypothesis | experimental_verification |
| ch-c0e9a0399af4 | Resolve: Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis | open | $2,045 | 0.80 | 2026-04-26 | single_hypothesis | experimental_verification |
| ch-66e36aa28f4c | Resolve: Prime Editing Precision Correction of APOE4 to APOE3 in Microglia | open | $2,046 | 0.80 | 2026-04-26 | single_hypothesis | experimental_verification |
| ch-ee7326bbc191 | Resolve: TREM2-mTOR Co-Agonism for Metabolic Reprogramming | open | $2,049 | 0.80 | 2026-04-26 | single_hypothesis | experimental_verification |
| ch-23a87a32-06 | Validate plasma GFAP as causal biomarker for BBB permeability in early AD | open | $400 | 0.00 | 2026-04-26 | hypothesis | open |
| ch-23a87a32-10 | Validate K48/K63 ubiquitin chain balance as therapeutic target in ALS | open | $500 | 0.00 | 2026-04-26 | hypothesis | open |
| ch-23a87a32-09 | Validate ATAC-seq chromatin remodeling as causal driver in age-related neurodege | open | $500 | 0.00 | 2026-04-26 | hypothesis | open |
| ch-23a87a32-08 | Validate ATAC-seq chromatin accessibility as causal driver in neurodegeneration | open | $500 | 0.00 | 2026-04-26 | hypothesis | open |
| ch-23a87a32-07 | Validate plasma LPS-binding protein as causal biomarker for gut-brain inflammati | open | $400 | 0.00 | 2026-04-26 | hypothesis | open |
| ch-23a87a32-05 | Validate TLR4 priming as actionable driver in gut-brain neurodegeneration axis | open | $450 | 0.00 | 2026-04-26 | hypothesis | open |
| ch-23a87a32-04 | Validate epigenetic drift causality in neurodegeneration DNA methylation | open | $500 | 0.00 | 2026-04-26 | hypothesis | open |
| ch-23a87a32-03 | Validate tight-junction remodeling as early biomarker for neurodegeneration | open | $400 | 0.00 | 2026-04-26 | hypothesis | open |
| ch-23a87a32-02 | Validate ubiquitylation-dependent UBQLN2 turnover as actionable driver in ALS | open | $500 | 0.00 | 2026-04-26 | hypothesis | open |
| ch-23a87a32-01 | Validate age-linked CpG drift as actionable driver in neurodegeneration | open | $500 | 0.00 | 2026-04-26 | hypothesis | open |
| ch-cdf84e150ae652f0e | Resolve: Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in Neurodegener | open | $250 | 0.81 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-f4e941a8e96c7dac4 | Resolve: IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microglia Interfac | open | $250 | 0.81 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-84437a12a73631602 | Resolve: Neutrophil Extracellular Trap (NET) Inhibition | open | $250 | 0.81 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-05c711c761c381b7a | Resolve: Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone Deficiency | open | $250 | 0.81 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-fa9c177cb3e1a1c89 | Resolve: CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion | open | $250 | 0.81 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-5add35b6b39559401 | Resolve: CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-Specific Vul | open | $500 | 0.81 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-b12352715a76ab029 | Resolve: SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to | open | $500 | 0.81 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-16e053f3e3fca90b4 | Resolve: TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearan | open | $500 | 0.81 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-ece759651d5cf71a0 | Resolve: Extracellular Vesicle Biogenesis Modulation | open | $500 | 0.81 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-88575018288eb9dc2 | Resolve: HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liqu | open | $1,000 | 0.82 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-7c12b6a2167e1e2ad | Resolve: Glymphatic-Mediated Tau Clearance Dysfunction | open | $250 | 0.82 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-b95b7796d9f54503f | Resolve: Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-Synuclein Ag | open | $250 | 0.82 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-9475d243382073d6f | Resolve: SIRT1 Activation Couples Mitochondrial Biogenesis to Ferroptosis Suppre | open | $250 | 0.82 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-d8ae140b2136230b8 | Resolve: Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopa | open | $250 | 0.82 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-3970ec85f6567cdc7 | Resolve: Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy T | open | $250 | 0.84 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-5bf666cc85b8b4b3f | Resolve: p38α Inhibitor and PRMT1 Activator Combination to Restore Physiological | open | $250 | 0.85 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-4f54ec92cd48ba124 | Resolve: Senescent Cell ASM-Complement Cascade Intervention | open | $500 | 0.85 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-2eb280778d2cf4a00 | Resolve: TREM2 R47H Variant-Driven Metabolic Dysfunction as the Primary Trigger | open | $500 | 0.86 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-a38790c5f62ea7cac | Resolve: Optogenetic restoration of hippocampal gamma oscillations via selective | open | $500 | 0.86 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-a9571954a2bf69dac | Resolve: Focused Ultrasound with Microbubble Contrast Agents for Antibody CNS De | open | $1,000 | 0.89 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-exp-eb18a30ad39d | Resolve: PERK Inhibitor GSK2606414 + GADD34 Mimetic Sephin1 Rescues eIF2alpha St | open | $5,700 | 8.34 | 2026-04-26 | single_target | experiment_resolve |
| ch-exp-d56a3d8ac15f | Resolve: Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State | open | $5,300 | 8.43 | 2026-04-26 | single_target | experiment_resolve |
| ch-exp-e029086215d4 | Resolve: Conditional TYROBP Knockdown in Early-Stage 5xFAD Mice Using CRISPRi-AA | open | $6,800 | 8.44 | 2026-04-26 | single_target | experiment_resolve |
| ch-exp-e2bda868301a | Resolve: nSMase2 Inhibitor DPTIP Rescues Synaptic Density in APPswe/PS1deltaE9 M | open | $5,500 | 8.44 | 2026-04-26 | single_target | experiment_resolve |
| ch-exp-7ca073e74de1 | Resolve: TREM2 R47H iPSC Co-culture Screen for A1 Astrocyte Polarisation Rescue | open | $5,200 | 8.75 | 2026-04-26 | single_target | experiment_resolve |
| ch-exp-1cc7793db396 | Resolve: TREM2 Agonist Antibody Rescue of Astrocyte-Microglia Signalling in 5xFA | open | $6,700 | 8.80 | 2026-04-26 | single_target | experiment_resolve |
| ch-exp-ea9df8780325 | Resolve: tFUS Targeting EC-II SST Interneurons Restores Hippocampal-Prefrontal G | open | $7,200 | 8.27 | 2026-04-26 | single_target | experiment_resolve |
| ch-exp-238627a7446f | Resolve: Closed-loop tFUS Enhances Glymphatic Clearance and Restores CA1 PV Inte | open | $7,700 | 8.27 | 2026-04-26 | single_target | experiment_resolve |
| ch-exp-8017e2cdb160 | Resolve: 40 Hz Auditory + Visual Gamma Stimulation Reduces Amyloid and Entrains | open | $5,900 | 8.38 | 2026-04-26 | single_target | experiment_resolve |