| ch-entorhinal-004 | Molecular Basis of Entorhinal Cortex Layer II Selective Vulnerability in Alzheim | open | $1,200,000 | 0.69 | 2026-04-17 | gap | open |
| ch-gut-brain-003 | Gut Microbial Metabolites as Early Causal Drivers of Alzheimer's Pathogenesis | open | $1,800,000 | 0.73 | 2026-04-17 | gap | open |
| ch-trem2-dam-001 | TREM2 Agonism vs Antagonism in Disease-Associated Microglia | open | $2,500,000 | 0.81 | 2026-04-17 | gap | open |
| ch-gba-synuclein-002 | Breaking the GBA—α-Synuclein Bidirectional Feedback Loop in Parkinson's Disease | open | $3,002,639 | 0.82 | 2026-04-17 | gap | open |
| ch-bbb-antibody-008 | Engineering Improved Blood-Brain Barrier Penetrance for Antibody Therapeutics in | open | $5,008,097 | 0.89 | 2026-04-17 | gap | open |
| ch_ot_ad_target_rank | Benchmark: Beat 0.816 AUROC on OT-AD Target Ranking | open | $238,859 | 0.82 | 2026-04-05 | benchmark | benchmark |
| ch-477d7e0eb652 | Solve: TDP-43 phase separation therapeutics for ALS-FTD | open | $97,690 | 0.47 | 2026-04-03 | gap | open |
| ch-ddae422c01e2 | Solve: Selective vulnerability of entorhinal cortex layer II neurons in AD | open | $133,954 | 0.47 | 2026-04-03 | gap | open |
| ch-b9f4b75af08a | Solve: 4R-tau strain-specific spreading patterns in PSP vs CBD | open | $92,374 | 0.47 | 2026-04-03 | gap | open |
| ch-eed5441cfcd5 | Solve: Perivascular spaces and glymphatic clearance failure in AD | open | $789,304 | 0.47 | 2026-04-03 | gap | open |
| ch-a6cad085371b | Solve: Sleep disruption as cause and consequence of neurodegeneration | open | $94,780 | 0.47 | 2026-04-03 | gap | open |
| ch-2bfb95ab25b2 | Solve: RNA binding protein dysregulation across ALS FTD and AD | open | $119,247 | 0.47 | 2026-04-03 | gap | open |
| ch-3335dd703cdd | Solve: Epigenetic clocks and biological aging in neurodegeneration | open | $136,009 | 0.47 | 2026-04-03 | gap | open |
| ch-3b2ac10d072b | Solve: Mitochondrial transfer between astrocytes and neurons | open | $209,004 | 0.47 | 2026-04-03 | gap | open |
| ch-8970c3846136 | Solve: Synaptic pruning by microglia in early AD | open | $187,963 | 0.47 | 2026-04-03 | gap | open |
| ch-337efaacc1da | Solve: Neuroinflammation resolution mechanisms and pro-resolving mediators | open | $962,725 | 0.47 | 2026-04-03 | gap | open |
| ch-f2032b8c801c | Solve: Senolytic therapy for age-related neurodegeneration | open | $962,784 | 0.47 | 2026-04-03 | gap | open |
| ch-7a0975cbae98 | Solve: Digital biomarkers and AI-driven early detection of neurodegeneration | open | $87,095 | 0.47 | 2026-04-03 | gap | open |
| ch-e428beee0193 | Solve: Autophagy-lysosome pathway convergence across neurodegenerative diseases | open | $147,036 | 0.47 | 2026-04-03 | gap | open |
| ch-54558277abc0 | Solve: APOE4 structural biology and therapeutic targeting strategies | open | $184,140 | 0.47 | 2026-04-03 | gap | open |
| ch-5550b7960324 | Solve: Microglia-astrocyte crosstalk amplification loops in neurodegeneration | open | $116,569 | 0.47 | 2026-04-03 | gap | open |
| ch-4496bac8da68 | Solve: Blood-brain barrier transport mechanisms for antibody therapeutics | open | $196,382 | 0.47 | 2026-04-03 | gap | open |
| ch-4608c0e624c9 | Solve: Astrocyte reactivity subtypes in neurodegeneration | open | $116,958 | 0.47 | 2026-04-03 | gap | open |
| ch-2b1a7919fce6 | Solve: Gut-brain axis metabolites in early AD pathogenesis | open | $43,700 | 0.47 | 2026-04-03 | gap | open |
| ch-b4d015ada1ae | Solve: GBA-alpha-synuclein bidirectional loop in Parkinson's | open | $962,824 | 0.47 | 2026-04-03 | gap | open |
| ch-c452c7179d47 | Solve: Extracellular vesicle biomarkers for early AD detection | open | $171,347 | 0.63 | 2026-04-03 | gap | open |