| ch-exp-1dea01758a85 | Resolve: Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat | open | $4,800 | 8.38 | 2026-04-26 | single_target | experiment_resolve |
| ch-3865e256f33a | Resolve: Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propagation | open | $250 | 6.00 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-7a9496bad0d6 | Resolve: SCFA Deficiency Disrupts Microglial Homeostasis and Promotes Neurodegen | open | $250 | 5.50 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-49804299bdf2 | Resolve: Enteric Nervous System Dysfunction as Self-Reinforcing Pathological Loo | open | $250 | 7.00 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-1cbcdff80aa2 | Resolve: LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target | open | $250 | 7.20 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-29c90cb762b262592 | Resolve: Optogenetic viral vector delivery via tFUS-mediated blood-brain barrier | open | $250 | 0.85 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-6a1c82ec1ff879bbe | Resolve: Microglial Senescence Prevention via TREM2/SASP Axis | open | $250 | 0.85 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-7604e6c5e12204945 | Resolve: Closed-loop focused ultrasound targeting EC-II PV interneurons to resto | open | $500 | 0.86 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-bbf7b5edd685bb6f2 | Resolve: Closed-loop tACS targeting EC-II PV interneurons to enhance perisomatic | open | $500 | 0.87 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-da4bb7f308c90cb4c | Resolve: Complement Cascade Inhibition Synaptic Protection | open | $500 | 0.87 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-ac4dea44dc398e01a | Resolve: GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance | open | $500 | 0.87 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-eb127ff6f177fce2a | Resolve: TREM2-Mediated Cholesterol Dysregulation in Microglial Senescence | open | $500 | 0.87 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-db674ee123dec866f | Resolve: Optimized Temporal Window for Metabolic Boosting Therapy Determines Suc | open | $500 | 0.88 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-9d5f230b032c55956 | Resolve: Epigenetic Priming Ketone Protocol | open | $1,000 | 0.88 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-de1acd9b333a6406f | Resolve: TREM2-APOE Axis Dissociation for Selective DAM Activation | open | $1,000 | 0.89 | 2026-04-26 | single_target | hypothesis_resolve |
| ch-7d01b640ae8f | Resolve: TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration | open | $15 | 0.89 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-2cebf7df4f39 | Resolve: SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence | open | $15 | 0.90 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-e364b953de72 | Resolve: CSF1R Inhibition-Mediated Microglial Replacement as a State Transition | open | $15 | 0.90 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-f5c099f2432d | Resolve: TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration | open | $50 | 0.91 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-db89ccfbda90 | Resolve: TREM2-ASM Crosstalk in Microglial Lysosomal Senescence | open | $50 | 0.91 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-546b14c9a493 | Resolve: Closed-loop transcranial focused ultrasound to restore hippocampal gamm | open | $50 | 0.91 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-97189a8ce90f | Resolve: Chromatin Remodeling-Mediated Nutrient Sensing Restoration | open | $50 | 0.91 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-1507cdbf0989 | Resolve: CYP46A1 Overexpression Gene Therapy | open | $50 | 0.92 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-04bfae0e710f | Resolve: Palmitoylethanolamide-Based Endocannabinoid Therapy | open | $50 | 0.92 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-f15eab749a10 | Resolve: CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microglial Senescen | open | $50 | 0.92 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-af73323749f2 | Resolve: Autophagy-Senescence Axis Therapeutic Window | open | $50 | 0.92 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-4cbf59e4dae1 | Resolve: HK2-Dependent Metabolic Checkpoint as the Gatekeeper of DAM Transition | open | $50 | 0.92 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-4741069d75f4 | Resolve: Plasma p-tau217-Triggered Exosome Dosing Maximizes lncRNA-0021 Therapeu | open | $50 | 0.94 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-f8c167459881 | Resolve: Multi-Biomarker Composite Index Surpassing Amyloid PET for Treatment Re | open | $50 | 0.93 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-34c3380b3551 | Resolve: Closed-loop focused ultrasound targeting CA1 PV interneurons to restore | open | $50 | 0.93 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-d3a9555bdcce | Resolve: Closed-loop transcranial focused ultrasound targeting EC-II SST interne | open | $50 | 0.92 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-3c92d1c1dc84 | Resolve: H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pru | open | $15 | 0.89 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-ea279cfbd63e | Resolve: Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Partially Irr | open | $15 | 0.89 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-97395e011f82 | Resolve: Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodeg | open | $15 | 0.89 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-d8d7dbc9a9da | Resolve: Hypothesis 4: Metabolic Coupling via Lactate-Shuttling Collapse | open | $15 | 0.89 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-4d90800c2f9d | Resolve: PLCG2 Allosteric Modulation as a Precision Therapeutic for TREM2-Depend | open | $50 | 0.94 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-9fa5ddebd09f | Resolve: Closed-loop optogenetic targeting PV interneurons to restore theta-gamm | open | $50 | 0.94 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-cd9e1cf10962 | Resolve: Closed-loop transcranial focused ultrasound targeting EC-II SST interne | open | $50 | 0.95 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-475bdad6aaec | Resolve: TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegeneration | open | $250 | 0.99 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-2a7487889e24 | Resolve: Metabolic Reprogramming to Reverse Senescence | open | $250 | 1.00 | 2026-04-25 | single_target | hypothesis_resolve |
| ch-tdp43-phase-006 | Therapeutic Targeting of TDP-43 Phase Separation in ALS-FTD | open | $4,005,598 | 0.84 | 2026-04-17 | gap | open |
| ch-apoe4-targeting-0 | Therapeutic Correction of APOE4 Structure and Function in Alzheimer's Disease | open | $3,501,754 | 0.83 | 2026-04-17 | gap | open |
| ch-ferroptosis-micro | ACSL4-Driven Ferroptosis in Disease-Associated Microglia: Therapeutic Opportunit | open | $2,600,000 | 0.80 | 2026-04-17 | gap | open |
| ch-epigenetic-circui | Nutrient-Sensing Epigenetic Circuit Reactivation to Restore Neuronal Resilience | open | $3,204,452 | 0.84 | 2026-04-17 | gap | open |
| ch-neuroinflam-resol | Pro-Resolving Mediators and Neuroinflammation Resolution in Chronic Neurodegener | open | $1,600,000 | 0.76 | 2026-04-17 | gap | open |
| ch-senolytic-013 | Senolytic Therapy for Age-Related Neurodegeneration: Target Cell Selectivity and | open | $2,800,000 | 0.80 | 2026-04-17 | gap | open |
| ch-digital-biomarker | Validated Digital Biomarkers for Pre-Symptomatic Neurodegeneration Detection | open | $1,000,000 | 0.73 | 2026-04-17 | gap | open |
| ch-autophagy-lysosom | Convergent Autophagy-Lysosome Pathway Therapeutics Across Neurodegenerative Dise | open | $2,200,000 | 0.80 | 2026-04-17 | gap | open |
| ch-microglia-astrocy | Characterizing and Interrupting Microglia-Astrocyte Neuroinflammatory Amplificat | open | $2,000,000 | 0.78 | 2026-04-17 | gap | open |
| ch-astrocyte-subtype | Functional Mapping of Disease-Specific Astrocyte Reactivity Subtypes in Neurodeg | open | $1,500,000 | 0.75 | 2026-04-17 | gap | open |