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Debates

915 items
IdQuestionQuality ScoreNum Hypotheses GeneratedNum RoundsStatusCreated AtAnalysis Id
pan_4be97f73Will single-cell and spatial atlases redefine disease by cell-state rather than 0.0000completed2026-06-09
pan_50a302b2Is the subjective psychedelic 'trip' necessary for the therapeutic effect, or wi0.0000completed2026-06-09
pan_43552306Do animal models fail to predict human neuro/immune outcomes so reliably that we0.0000completed2026-06-09
pan_4051c31cCan AI systems generate genuinely novel scientific hypotheses, or can they only 0.0000completed2026-06-09
pan_d4570ad9Is aging a single targetable process, and does reversing epigenetic information 0.0000completed2026-06-09
pan_b0edb891Is impaired sleep-dependent glymphatic clearance a genuine, treatable cause of d0.0000completed2026-06-09
pan_8be0f039Is depression better explained as an inflammatory and circuit-plasticity disorde0.0000completed2026-06-09
pan_17fedfe8Does Parkinson's disease begin in the gut and ascend the vagus nerve (body-first0.0000completed2026-06-09
pan_e6e64f1cAre microglia net-protective early in neurodegeneration and net-destructive late0.0000completed2026-06-09
pan_be558375Is chronic low-grade inflammation (inflammaging) a root cause of age-related dis0.0000completed2026-06-09
pan_15e04626Is cancer fundamentally an immune-evasion disease that should be treated immunot0.0000completed2026-06-09
pan_784c1419Do clonally-expanded T cells invading the brain drive Parkinson's and Alzheimer'0.0000completed2026-06-09
pan_ff9d3606Does the modest clinical benefit of lecanemab and donanemab confirm the amyloid 0.0000completed2026-06-09
single-3079d6ed9438single-round debate0.0000completed2026-05-16
single-a96db4ce9ffcsingle-round debate0.0000completed2026-05-16
multi-50a504dce44bmulti-round debate with scores0.0000completed2026-05-16
single-178a8512f561single-round debate0.0000completed2026-05-16
single-a9b62626d147single-round debate0.0000completed2026-05-16
multi-0f14086947ccmulti-round debate with scores0.0000completed2026-05-16
single-470a6fb467f2single-round debate0.0000completed2026-05-16
single-b782df55846bsingle-round debate0.0000completed2026-05-16
multi-f5be8cd2a308multi-round debate with scores0.0000completed2026-05-16
single-ef759a695511single-round debate0.0000completed2026-05-16
sess_SDA-2026-05-10-Test0.7474completed2026-05-10SDA-2026-05-10-gap-test-20260425-224949
sess_SDA-2026-05-06-Test0.7774completed2026-05-06SDA-2026-05-06-gap-test-20260425-224949
sess_SDA-2026-05-05-Test0.5504completed2026-05-05SDA-2026-05-05-gap-test-20260425-224949
pan_83f55887what does the Allen Institute do?0.0000completed2026-05-04
sess_SDA-2026-05-04-Test0.5944completed2026-05-04SDA-2026-05-04-gap-test-20260425-224949
sess_SDA-2026-05-03-Test0.7074completed2026-05-03SDA-2026-05-03-gap-test-20260425-224949
sess_SDA-2026-05-02-Test0.6504completed2026-05-02SDA-2026-05-02-gap-test-20260425-224949
sess_SDA-2026-05-01-Test0.8074completed2026-05-01SDA-2026-05-01-gap-test-20260425-224949
sess_SDA-2026-04-30-Test0.7474completed2026-04-30SDA-2026-04-30-gap-test-20260425-224949
sess_SDA-2026-04-29-Test0.7674completed2026-04-29SDA-2026-04-29-gap-test-20260425-224949
sess-adv6-h_48858e2aSecond debate: Microglial TREM2-SYK Pathway Enhancement0.5714completed2026-04-28SDA-2026-04-03-gap-seaad-v4-20260402065846
sess-adv6-h_f32ba823Second debate: Hypothesis 1: MANF/CDNF Signaling as Primary Neuroprotective Effe0.5414completed2026-04-28
SRB-adv3-paper-40040Structured Research Brief: Tau dysfunction destabilizes labile pool0.7102completed2026-04-28
SRB-adv3-10-170057-aStructured Research Brief: Hypothesis 1: MANF/CDNF Signaling as Primary Neuropro0.7002completed2026-04-28
SRB-adv3-9-hyp-var-6Structured Research Brief: APOE4-Specific Proteolytic Fragment Inhibition Therap0.7902completed2026-04-28
SRB-adv3-paper-39257Structured Research Brief: Tau/MAP6 ratio as a master switch for microtubule dyn0.7202completed2026-04-28
SRB-adv3-10-150509-7Structured Research Brief: METTL3-Mediated m6A Modification of lncRNA-0021 Regul0.6502completed2026-04-28
SRB-adv3-10-150544-eStructured Research Brief: Lysosomal Cathepsin-Dependent Tau Clearance0.6602completed2026-04-28
SRB-adv3--29-hyp-3f9Structured Research Brief: Synaptic Vesicle Cycle Hijacking: Shared Convergent M0.7202completed2026-04-28
SRB-adv3-9-hyp-lyso-Structured Research Brief: GBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch0.7002completed2026-04-28
SRB-adv3-9-hyp-immunStructured Research Brief: Astrocyte C3aR Signaling as Bifurcation Point for A1/0.6702completed2026-04-28
SRB-adv3-9-hyp-lyso-Structured Research Brief: GBA1-Deficiency Disrupts Mitochondrial- Lysosomal Con0.7002completed2026-04-28
SRB-adv3-9-hyp-lyso-Structured Research Brief: PD-Associated GWAS Variants in CTSO and CTSF Genes Cr0.6902completed2026-04-28
SRB-adv3-9-hyp-lyso-Structured Research Brief: SNCA Oligomer Binding to LAMP2A Cytosolic Tail Preven0.6802completed2026-04-28
SRB-adv3-9-hyp-lyso-Structured Research Brief: LAMP2A Liquid-Liquid Phase Separation Defects in Dopa0.7202completed2026-04-28
SRB-adv3--29-hyp-992Structured Research Brief: PINK1/Parkin–TREM2 Axis: Convergent Mitophagy Failure0.7302completed2026-04-28
SRB-adv3-9-hyp-lyso-Structured Research Brief: Exosomal SNCA Propagation from Lysosome-Compromised N0.7202completed2026-04-28
123
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