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Debates

841 items
IdQuestionQuality ScoreNum Hypotheses GeneratedNum RoundsStatusCreated AtAnalysis Id
ds-analogy-0071fb6dCross-disease analogy hypothesis: does the mechanism transfer? [cva-21ecbe1b170b0.0003pending2026-04-28
ds-analogy-07d0d4f0Cross-disease analogy hypothesis: does the mechanism transfer? [cva-ca8efa5251c70.0003pending2026-04-28
ds-analogy-83f16d1cCross-disease analogy hypothesis: does the mechanism transfer? [cva-a54efa09cf070.0003pending2026-04-28
ds-analogy-fac64406Cross-disease analogy hypothesis: does the mechanism transfer? [cva-18b1df861e390.0003pending2026-04-28
ds-analogy-16052934Cross-disease analogy hypothesis: does the mechanism transfer? [cva-e503e171657c0.0003pending2026-04-28
sess_SDA-TEST-PREREGTest question for preregistration0.7774completed2026-04-28SDA-TEST-PREREG-003
sess_SDA-2026-04-27-Methodology challenge: notebook 'Astrocyte reactivity subtypes in neurodegenerat0.6434completed2026-04-28SDA-2026-04-27-gap-methodol-20260427-035148-9ab1842d
sess_SDA-2026-04-27-Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia0.6434completed2026-04-28SDA-2026-04-27-gap-methodol-20260427-035148-7b3b3df4
sess_AD-MASTER-PLAN-TREM2 enhancement reduces microglial dysfunction and downstream tau pathology, s0.6434completed2026-04-28AD-MASTER-PLAN-TREM2-20260428030753
sess_AD-MASTER-PLAN-APOE4-driven lipid dysregulation and synaptic phagocytosis drive AD; converting 0.6434completed2026-04-28AD-MASTER-PLAN-APOE-20260428030754
sess_AD-MASTER-PLAN-BDNF-mediated hippocampal synaptic rescue restores CA3-CA1 connectivity and prev0.6434completed2026-04-28AD-MASTER-PLAN-BDNF-20260428030755
sess_AD-MASTER-PLAN-GFAP-positive reactive astrocytes mediate regional vulnerability through dysfunc0.6434completed2026-04-28AD-MASTER-PLAN-GFAP-20260428030756
sess_AD-MASTER-PLAN-LRP1-mediated tau uptake disruption in neurons initiates the earliest tau propag0.6434completed2026-04-28AD-MASTER-PLAN-LRP1-20260428030757
sess_SDA-2026-04-28-Is microglial priming (TREM2/CX3CR1/complement-C1q) genuinely causally upstream 0.6434completed2026-04-28SDA-2026-04-28-microglial-priming-causal-nd
sess_SDA-causal-bencHow does SciDEX's debate-engine compare to other LLM methods for causal discover0.6434completed2026-04-28SDA-causal-benchmark-20260428-035713
sess_SDA-2026-04-28-Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia0.6434completed2026-04-28SDA-2026-04-28-gap-methodol-20260427-035148-7b3b3df4
sess_8f05a068-5b1e-4How do APOE4-driven lipid droplet and cholesterol-metabolism differences in micr0.7614completed2026-04-288f05a068-5b1e-4f32-8ca9-2f375b5dbaf3
sess_52661eaf-79f8-4What are the biophysical determinants — RNA binding stoichiometry, post-translat0.6734completed2026-04-2852661eaf-79f8-4647-8f48-3389f5af4d59
sess_687fb884-6d31-4What are the relative contributions of cell-autonomous motor neuron mechanisms v0.6734completed2026-04-28687fb884-6d31-47c3-a83f-074bad980db6
sess_db9a224d-3ebb-4Which non-neuronal cell types (astrocytes, oligodendrocytes, pericytes) exhibit 0.6734completed2026-04-28db9a224d-3ebb-429c-8f02-b703d71ca211
sess_b7f886d9-da3f-4How does N6-methyladenosine (m6A) RNA modification alter alpha-synuclein mRNA st0.6734completed2026-04-28b7f886d9-da3f-4e0d-a8a8-9c262e268796
sess_f7f8019f-08f6-4How does the CCL2-CCR2 chemokine axis at the neuromuscular junction drive select0.6734completed2026-04-28f7f8019f-08f6-428b-adff-85e8ea202b60
sess_0ed3c364-07fd-4What is the precise causal sequence of molecular events linking TDP-43 nuclear c0.6734completed2026-04-280ed3c364-07fd-4620-8e90-8bd33c14e370
sess_bf5094c7-8ae0-4Do PD-associated genetic aging landscape variants causally accelerate epigenetic0.6734completed2026-04-28bf5094c7-8ae0-4331-9871-d6f3078387c5
sess_8ec36980-febb-4Which proteogenomic network hubs identified by multi-omics PD studies are drugga0.6734completed2026-04-288ec36980-febb-4093-a5a1-387ea5768480
sess_a7f528aa-20c4-4How do VEGF family gene variants identified by single-cell GWAS analysis alter c0.6734completed2026-04-28a7f528aa-20c4-409d-a8c3-e2662850e63d
sess_457c5bc3-21d8-4What cell-type-specific gene regulatory networks mediate the DPP6 GWAS signal fo0.6734completed2026-04-28457c5bc3-21d8-42a3-bb99-b0fc6f3f9554
sess_dfb32151-9c40-4What sex-specific microglial transcriptional states emerge in response to amyloi0.6734completed2026-04-28dfb32151-9c40-452d-8063-0c57bae5c3d6
sess_ana_f07c10cf-7eCan targeting oxidative stress pathways (NRF2, SOD1, mitochondrial ROS) upstream0.6206completed2026-04-28f07c10cf-7e5a-4a02-9479-327aa5c963b5
sess_ana_26866808-a2How do GWAS-identified PD risk variants at the LRRK2 locus alter lysosomal membr0.8906completed2026-04-2826866808-a2cf-4e6e-976d-bc900aef6e0a
sess_ana_0847737b-b8What spatially resolved cell-cell communication networks between oligodendrocyte0.8306completed2026-04-280847737b-b8f3-4130-b8c2-65015add1117
ds-target-d9e2b8db2aShould neuronal identity transcription factors be prioritized as therapeutic tar0.7203completed2026-04-28
sess_ext_h-2600483e_Extended debate: CYP46A1 Overexpression Gene Therapy0.9506completed2026-04-28SDA-2026-04-01-gap-lipid-rafts-2026-04-01
sess_ext_SDA-2026-04Extended debate: Metabolic Reprogramming to Reverse Senescence0.9506completed2026-04-28SDA-2026-04-04-gap-senescent-clearance-neuro
sess_ext_h-var-de167Extended debate: TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegenera0.9506completed2026-04-28SDA-2026-04-26-trem2-showcase
sess_ext_h-var-58e76Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma ent0.9506completed2026-04-28SDA-2026-04-03-26abc5e5f9f2
sess_ext_h-var-3b982Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau 0.9506completed2026-04-28SDA-2026-04-03-26abc5e5f9f2
pan_e0f8efc0are LLMs conscious?0.0000completed2026-04-28
pan_f11f02fcIs the amyloid cascade hypothesis still the best explanation for AD?0.5000completed2026-04-27
test-chamber-sessiontest question0.5000completed2026-04-27
pan_f3022c8fIs the amyloid cascade hypothesis still the best explanation for AD?0.5000completed2026-04-27
test-chamber-sessiontest question0.5000completed2026-04-27
test-debate-1ba85200Does APOE4 drive tau propagation via mitochondrial dysfunction?0.7500completed2026-04-27
test-debate-7bf87108Does APOE4 drive tau propagation via mitochondrial dysfunction?0.7500completed2026-04-27
pan_46017aa0smoke - what is the strongest evidence against the amyloid cascade0.5000completed2026-04-27
pan_01105bdcwhat is the root cause of alzheimer's0.5000completed2026-04-27
pan_41ec088esmoke - what is the strongest evidence against the amyloid cascade0.5000completed2026-04-27
pan_b2789997smoke - what is the strongest evidence against the amyloid cascade0.5000completed2026-04-27
pan_af7f06b2smoke0.5000completed2026-04-27
pan_853885a7smoke - what is the strongest evidence against the amyloid cascade hypothesis0.5000completed2026-04-27
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