| sess_hyp_h-3b539acf_ | Neutrophil Extracellular Trap (NET) Inhibition: ## Mechanistic Overview
Neutroph | 0.80 | 0 | 4 | completed | 2026-04-27 | |
| pan_cc6c3500 | smoke test - what is dopamine | 0.50 | 0 | 0 | completed | 2026-04-27 | |
| pan_b6c942aa | what is the root cause of alzheimer's | 0.50 | 0 | 0 | completed | 2026-04-27 | |
| sess-hyp-ec7c58c65ca | Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV inte | 0.65 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-03-26abc5e5f9f2 |
| sess-hyp-ac3663c415c | Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration | 0.46 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-04-gap-epigenetic-reprog-b685190e |
| sess-hyp-3a782e02e23 | Debate: TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation | 0.59 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-15-gap-debate-20260410-112522-57d1cc4f |
| sess-hyp-81fef13b19a | Debate: Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Assembly During | 0.71 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-15-gap-pubmed-20260411-084510-fbfafe2c |
| sess-hyp-87b85c3b19f | Debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagati | 0.71 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-03-26abc5e5f9f2 |
| sess-hyp-8a90163989d | Debate: Closed-loop transcranial focused ultrasound to restore hippocampal gamma | 0.87 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-03-26abc5e5f9f2 |
| sess-hyp-a599791d436 | Debate: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firin | 0.48 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-03-26abc5e5f9f2 |
| sess-hyp-f093318d54c | Debate: Liquid-to-Solid Transition Pathology Reveals Granule Weak Points | 0.58 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-07-gap-pubmed-20260406-041428-53b81741 |
| sess-hyp-10e827fe5d5 | Debate: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Primin | 0.12 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| sess-hyp-822bfd0cb89 | Debate: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE P | 0.42 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| sess-hyp-ecde86af7db | Debate: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability i | 0.48 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| sess-hyp-af5c7b00499 | Debate: Enhancing Microglial Phagocytosis of Extracellular Tau via TREM2 Activat | 0.34 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-04-gap-tau-prion-spreading |
| pan_e387991a | what role does microglial TREM2 play in Alzheimer disease pathology | 0.50 | 0 | 0 | completed | 2026-04-27 | |
| pan_81d65a6d | what role does microglial TREM2 play in Alzheimer disease pathology | 0.50 | 0 | 0 | completed | 2026-04-27 | |
| sess-hyp-1b87d283fc0 | Debate: TREM2 Microglial Activation Rescues Amyloid Clearance in AD | 0.75 | 0 | 4 | completed | 2026-04-27 | test-hypothesis-fixtures-v1 |
| sess-hyp-9e94c8fee48 | Debate: TBK1 Loss Locks Microglia in an Aged/Senescent Transcriptional State, Fu | 0.33 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-26-gap-20260425215446 |
| sess-hyp-2d2eb00ec3a | Debate: TREM2 Deficiency Drives Microglial Senescence via Lipid Metabolism Dysre | 0.46 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-06-gap-pubmed-20260406-041439-5f43216e |
| sess-hyp-9935d8a1fc1 | Debate: Closed-loop tACS targeting EC-II somatostatin interneurons to restore de | 0.54 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-03-26abc5e5f9f2 |
| sess-hyp-78891e7dfa8 | Debate: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes | 0.47 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| pan_efca73be | test convene from monitor | 0.50 | 0 | 0 | completed | 2026-04-27 | |
| sess-hyp-0bb6b3633d4 | Debate: Microglial TREM2 downregulation impairs damage-associated response in la | 0.21 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-04-analysis_sea_ad_001 |
| pan_d51d054a | what is the root cause of alzheimer's | 0.50 | 0 | 0 | completed | 2026-04-27 | |
| sess-hyp-85e15db6a83 | Debate: Closed-loop transcranial focused ultrasound with real-time gamma feedbac | 0.19 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-03-26abc5e5f9f2 |
| sess-hyp-24b92eb41b4 | Debate: SCFA Deficiency Drives Microglial Hyperactivation via GPR43/NF-κB Dysreg | 0.13 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-26-gap-20260425-225305 |
| sess_hypdebate_h_af0 | Hypothesis debate: Complement C1q-Mediated Synaptic Pruning Drives Early Cogniti | 0.50 | 1 | 4 | completed | 2026-04-27 | legacy-pre-pipeline-import-v1 |
| sess_hypdebate_h_var | Hypothesis debate: Closed-loop transcranial alternating current stimulation to r | 0.40 | 1 | 4 | completed | 2026-04-27 | SDA-2026-04-03-26abc5e5f9f2 |
| sess_hypdebate_h_var | Hypothesis debate: Closed-loop transcranial focused ultrasound to restore hippoc | 0.50 | 1 | 4 | completed | 2026-04-27 | SDA-2026-04-03-26abc5e5f9f2 |
| sess_hypdebate_h_var | Hypothesis debate: TREM2-Mediated Microglial Dysfunction Disrupts Perivascular T | 0.50 | 1 | 4 | completed | 2026-04-27 | SDA-2026-04-26-trem2-showcase |
| sess_hypdebate_h_9d2 | Hypothesis debate: Membrane Cholesterol Gradient Modulators | 0.50 | 1 | 4 | completed | 2026-04-27 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| sess_hypdebate_h_23e | Hypothesis debate: APOE4 Isoform Correction via Lipidation Enhancement as CTE Ri | 0.50 | 1 | 4 | completed | 2026-04-27 | SDA-2026-04-14-gap-pubmed-20260410-185318-186b0446 |
| test-session-4 | Test debate topic for persona ladder testing | 0.50 | 0 | 0 | completed | 2026-04-27 | |
| test-session-3 | Test debate topic for persona ladder testing | 0.50 | 0 | 0 | completed | 2026-04-27 | |
| test-session-2 | Test debate topic for persona ladder testing | 0.50 | 0 | 0 | completed | 2026-04-27 | |
| test-session-1 | Test debate topic for persona ladder testing | 0.50 | 0 | 0 | completed | 2026-04-27 | |
| test-session-0 | Test debate topic for persona ladder testing | 0.50 | 0 | 0 | completed | 2026-04-27 | |
| sess_hypdebate_SDA_2 | Hypothesis debate: Metabolic Reprogramming to Reverse Senescence | 0.44 | 1 | 4 | completed | 2026-04-27 | SDA-2026-04-04-gap-senescent-clearance-neuro |
| sess_hypdebate_h_var | Hypothesis debate: Closed-loop transcranial focused ultrasound with 40Hz gamma e | 0.54 | 1 | 4 | completed | 2026-04-27 | SDA-2026-04-03-26abc5e5f9f2 |
| sess_hypdebate_h_var | Hypothesis debate: Closed-loop transcranial focused ultrasound with 40Hz gamma e | 0.65 | 1 | 4 | completed | 2026-04-27 | SDA-2026-04-03-26abc5e5f9f2 |
| sess_hypdebate_h_var | Should '40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Sele | 0.52 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| sess_hypdebate_h_var | Should 'ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matt | 0.72 | 0 | 4 | completed | 2026-04-27 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| sess_hypdebate_h_44b | Hypothesis debate: TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxici | 0.49 | 1 | 4 | completed | 2026-04-27 | legacy-pre-pipeline-import-v1 |
| sess_hypdebate_h_72c | Hypothesis debate: C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD | 0.58 | 1 | 4 | completed | 2026-04-27 | test-hypothesis-fixtures-v1 |
| sess_hypdebate_h_b66 | Hypothesis debate: Stathmin-2 Splice Switching to Prevent Axonal Degeneration Ac | 0.49 | 1 | 4 | completed | 2026-04-27 | SDA-2026-04-13-gap-20260410-172514 |
| sess_hypdebate_h_e7e | Hypothesis debate: Microbial Inflammasome Priming Prevention | 0.48 | 1 | 4 | completed | 2026-04-27 | SDA-2026-04-01-gap-20260401-225155 |
| sess_hypdebate_h_var | Hypothesis debate: GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Cle | 0.60 | 1 | 4 | completed | 2026-04-27 | SDA-2026-04-03-26abc5e5f9f2 |
| fea-679d8d152a8c | Does this figure provide adequate evidence for the claim 'Microglial Activation | 0.52 | 0 | 3 | completed | 2026-04-27 | |
| sess_gap-methodol-20 | Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua | 0.50 | 0 | 2 | scheduled | 2026-04-27 | |