| SRB-adv2-ipidomics-d | Structured research brief (iter2): ω-3 Docosahexaenoic Acid (DHA) Epoxide Genera | 0.64 | 0 | 2 | completed | 2026-04-28 | SDA-2026-04-16-frontier-lipidomics-dcdbc360 |
| SRB-adv--gap-2026041 | Structured research brief: Stathmin-2 Splice Switching to Prevent Axonal Degener | 0.73 | 0 | 2 | completed | 2026-04-28 | SDA-2026-04-13-gap-20260410-172514 |
| SRB-adv--29-hyp-9d07 | Structured research brief: ATM Kinase Hyperactivation Triggers DNA Damage Respon | 0.70 | 0 | 2 | completed | 2026-04-28 | |
| SRB-adv--29-hyp-870c | Structured research brief: eIF2α Phosphorylation Imbalance Creates Integrated St | 0.69 | 0 | 2 | completed | 2026-04-28 | |
| SRB-adv-0410-170057- | Structured research brief: Hypothesis 4: Metabolic Coupling via Lactate-Shuttlin | 0.74 | 0 | 2 | completed | 2026-04-28 | |
| SRB-adv--29-hyp-9d62 | Structured research brief: RBM45 Liquid-Liquid Phase Separation Dominance Hijack | 0.65 | 0 | 2 | completed | 2026-04-28 | |
| SRB-adv-0410-150544- | Structured research brief: Complement Cascade Inhibition Synaptic Protection | 0.75 | 0 | 2 | completed | 2026-04-28 | |
| SRB-adv-0410-150509- | Structured research brief: Gamma Oscillation Entrainment Enhances lncRNA-9969-Me | 0.71 | 0 | 2 | completed | 2026-04-28 | |
| SRB-adv--29-hyp-c5d2 | Structured research brief: SFPQ Paralog Displacement Triggers Cryptic Polyadenyl | 0.64 | 0 | 2 | completed | 2026-04-28 | |
| SRB-adv--29-hyp-006d | Structured research brief: hnRNP A2/B1 Staufen2-Mediated Axonal RNA Granule Tran | 0.70 | 0 | 2 | completed | 2026-04-28 | |
| SRB-adv-0410-174000- | Structured research brief: Sequential Iron Chelation (Deferoxamine) and GPX4 Res | 0.76 | 0 | 2 | completed | 2026-04-28 | |
| SRB-adv--29-hyp-e448 | Structured research brief: GLE1-Mediated mRNA Export Defect Creates Translation- | 0.69 | 0 | 2 | completed | 2026-04-28 | |
| SRB-adv--29-hyp-54f9 | Structured research brief: TIA1 Low-Complexity Domain Oxidation Drives Aberrant | 0.69 | 0 | 2 | completed | 2026-04-28 | |
| SRB-adv-6-04-29-hyp- | Structured research brief: Dual-Receptor Antibody Shuttling | 0.75 | 0 | 2 | completed | 2026-04-28 | |
| SRB-adv--29-hyp-0144 | Structured research brief: MATR3 Nuclear Body Disruption Impairs RNA Processing | 0.66 | 0 | 2 | completed | 2026-04-28 | |
| sess_SDA-2026-04-28- | Test | 0.75 | 7 | 4 | completed | 2026-04-28 | SDA-2026-04-28-gap-test-20260425-224949 |
| sess_SRB-2026-04-28- | Structured research brief for hypothesis h-var-b7e4505525: Closed-loop transcran | 0.63 | 7 | 4 | completed | 2026-04-28 | SRB-2026-04-28-h-var-b7e4505525 |
| sess_SRB-2026-04-28- | Structured research brief for hypothesis h-var-e2b5a7e7db: GluN2B-Mediated Thala | 0.82 | 7 | 4 | completed | 2026-04-28 | SRB-2026-04-28-h-var-e2b5a7e7db |
| sess_SDA-2026-04-28- | Which AD, PD, ALS, and FTD mechanisms recur across disease boundaries and yield | 0.72 | 7 | 4 | completed | 2026-04-28 | SDA-2026-04-28-cross-disease-synthesis |
| sess_SRB-2026-04-28- | Structured research brief for hypothesis h-var-e95d2d1d86: Closed-loop optogenet | 0.72 | 7 | 4 | completed | 2026-04-28 | SRB-2026-04-28-h-var-e95d2d1d86 |
| sess_SRB-2026-04-28- | Structured research brief for hypothesis h-bdbd2120: Gamma entrainment therapy t | 0.86 | 7 | 4 | completed | 2026-04-28 | SRB-2026-04-28-h-bdbd2120 |
| sess_SRB-2026-04-28- | Structured research brief for hypothesis h-var-a4975bdd96: Closed-loop transcran | 0.57 | 7 | 4 | completed | 2026-04-28 | SRB-2026-04-28-h-var-a4975bdd96 |
| ds-analogy-b83c6f8a | Cross-disease analogy hypothesis: does the mechanism transfer? [cva-b3b4479bffa2 | 0.50 | 0 | 1 | pending | 2026-04-28 | |
| sess_SDA-2026-04-28- | Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua | 0.76 | 7 | 4 | completed | 2026-04-28 | SDA-2026-04-28-gap-methodol-20260427-041425-9e73b245 |
| ds-analogy-0071fb6d | Cross-disease analogy hypothesis: does the mechanism transfer? [cva-21ecbe1b170b | 0.50 | 0 | 1 | pending | 2026-04-28 | |
| ds-analogy-07d0d4f0 | Cross-disease analogy hypothesis: does the mechanism transfer? [cva-ca8efa5251c7 | 0.50 | 0 | 1 | pending | 2026-04-28 | |
| ds-analogy-83f16d1c | Cross-disease analogy hypothesis: does the mechanism transfer? [cva-a54efa09cf07 | 0.50 | 0 | 1 | pending | 2026-04-28 | |
| ds-analogy-fac64406 | Cross-disease analogy hypothesis: does the mechanism transfer? [cva-18b1df861e39 | 0.50 | 0 | 1 | pending | 2026-04-28 | |
| ds-analogy-16052934 | Cross-disease analogy hypothesis: does the mechanism transfer? [cva-e503e171657c | 0.50 | 0 | 1 | pending | 2026-04-28 | |
| sess_SDA-TEST-PREREG | Test question for preregistration | 0.77 | 7 | 4 | completed | 2026-04-28 | SDA-TEST-PREREG-003 |
| sess_SDA-2026-04-27- | Methodology challenge: notebook 'Astrocyte reactivity subtypes in neurodegenerat | 0.64 | 3 | 4 | completed | 2026-04-28 | SDA-2026-04-27-gap-methodol-20260427-035148-9ab1842d |
| sess_SDA-2026-04-27- | Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia | 0.64 | 3 | 4 | completed | 2026-04-28 | SDA-2026-04-27-gap-methodol-20260427-035148-7b3b3df4 |
| sess_AD-MASTER-PLAN- | TREM2 enhancement reduces microglial dysfunction and downstream tau pathology, s | 0.64 | 3 | 4 | completed | 2026-04-28 | AD-MASTER-PLAN-TREM2-20260428030753 |
| sess_AD-MASTER-PLAN- | APOE4-driven lipid dysregulation and synaptic phagocytosis drive AD; converting | 0.64 | 3 | 4 | completed | 2026-04-28 | AD-MASTER-PLAN-APOE-20260428030754 |
| sess_AD-MASTER-PLAN- | BDNF-mediated hippocampal synaptic rescue restores CA3-CA1 connectivity and prev | 0.64 | 3 | 4 | completed | 2026-04-28 | AD-MASTER-PLAN-BDNF-20260428030755 |
| sess_AD-MASTER-PLAN- | GFAP-positive reactive astrocytes mediate regional vulnerability through dysfunc | 0.64 | 3 | 4 | completed | 2026-04-28 | AD-MASTER-PLAN-GFAP-20260428030756 |
| sess_AD-MASTER-PLAN- | LRP1-mediated tau uptake disruption in neurons initiates the earliest tau propag | 0.64 | 3 | 4 | completed | 2026-04-28 | AD-MASTER-PLAN-LRP1-20260428030757 |
| sess_SDA-2026-04-28- | Is microglial priming (TREM2/CX3CR1/complement-C1q) genuinely causally upstream | 0.64 | 3 | 4 | completed | 2026-04-28 | SDA-2026-04-28-microglial-priming-causal-nd |
| sess_SDA-causal-benc | How does SciDEX's debate-engine compare to other LLM methods for causal discover | 0.64 | 3 | 4 | completed | 2026-04-28 | SDA-causal-benchmark-20260428-035713 |
| sess_SDA-2026-04-28- | Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia | 0.64 | 3 | 4 | completed | 2026-04-28 | SDA-2026-04-28-gap-methodol-20260427-035148-7b3b3df4 |
| sess_8f05a068-5b1e-4 | How do APOE4-driven lipid droplet and cholesterol-metabolism differences in micr | 0.76 | 1 | 4 | completed | 2026-04-28 | 8f05a068-5b1e-4f32-8ca9-2f375b5dbaf3 |
| sess_52661eaf-79f8-4 | What are the biophysical determinants — RNA binding stoichiometry, post-translat | 0.67 | 3 | 4 | completed | 2026-04-28 | 52661eaf-79f8-4647-8f48-3389f5af4d59 |
| sess_687fb884-6d31-4 | What are the relative contributions of cell-autonomous motor neuron mechanisms v | 0.67 | 3 | 4 | completed | 2026-04-28 | 687fb884-6d31-47c3-a83f-074bad980db6 |
| sess_db9a224d-3ebb-4 | Which non-neuronal cell types (astrocytes, oligodendrocytes, pericytes) exhibit | 0.67 | 3 | 4 | completed | 2026-04-28 | db9a224d-3ebb-429c-8f02-b703d71ca211 |
| sess_b7f886d9-da3f-4 | How does N6-methyladenosine (m6A) RNA modification alter alpha-synuclein mRNA st | 0.67 | 3 | 4 | completed | 2026-04-28 | b7f886d9-da3f-4e0d-a8a8-9c262e268796 |
| sess_f7f8019f-08f6-4 | How does the CCL2-CCR2 chemokine axis at the neuromuscular junction drive select | 0.67 | 3 | 4 | completed | 2026-04-28 | f7f8019f-08f6-428b-adff-85e8ea202b60 |
| sess_0ed3c364-07fd-4 | What is the precise causal sequence of molecular events linking TDP-43 nuclear c | 0.67 | 3 | 4 | completed | 2026-04-28 | 0ed3c364-07fd-4620-8e90-8bd33c14e370 |
| sess_bf5094c7-8ae0-4 | Do PD-associated genetic aging landscape variants causally accelerate epigenetic | 0.67 | 3 | 4 | completed | 2026-04-28 | bf5094c7-8ae0-4331-9871-d6f3078387c5 |
| sess_8ec36980-febb-4 | Which proteogenomic network hubs identified by multi-omics PD studies are drugga | 0.67 | 3 | 4 | completed | 2026-04-28 | 8ec36980-febb-4093-a5a1-387ea5768480 |
| sess_a7f528aa-20c4-4 | How do VEGF family gene variants identified by single-cell GWAS analysis alter c | 0.67 | 3 | 4 | completed | 2026-04-28 | a7f528aa-20c4-409d-a8c3-e2662850e63d |