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Debates

915 items
IdQuestionQuality ScoreNum Hypotheses GeneratedNum RoundsStatusCreated AtAnalysis Id
sess_SDA-2026-04-13-The title suggests B cells actively maintain tolerance to AQP4, but the specific0.7934completed2026-04-13SDA-2026-04-13-gap-pubmed-20260410-142329-c1db787b
sess_SDA-2026-04-13-While the study shows HDAC1/2 deletion improves amyloid clearance and cognition,0.9574completed2026-04-13SDA-2026-04-13-gap-pubmed-20260410-110327-26e1d6c7
sess_SDA-2026-04-13-The debate highlighted promising PTMs like K280 acetylation and O-GlcNAcylation 0.6504completed2026-04-13SDA-2026-04-13-gap-debate-20260412-094612-a2e3bd09
sess_SDA-2026-04-13-RNA binding protein dysregulation across ALS FTD AD0.5004completed2026-04-13SDA-2026-04-13-gap-20260410-172514
sess_SDA-2026-04-12-The debate highlighted BBB penetration as a major hurdle for SPM therapeutics bu0.6604completed2026-04-13SDA-2026-04-12-gap-debate-20260410-113110-2059f65f
sess_SDA-2026-04-04-The provided transcript contains only speaker labels [Theorist] and [Synthesizer0.9574completed2026-04-13SDA-2026-04-04-gap-debate-20260403-222510-20260402
sess_SDA-2026-04-12-The debate highlighted a critical dosing paradox where both hypo- and hypermethy0.8234completed2026-04-12SDA-2026-04-12-gap-debate-20260410-113051-5dce7651
sess_SDA-2026-04-12-The debate revealed conflicting evidence about whether connexin-43 mediates mito0.7434completed2026-04-12SDA-2026-04-12-gap-debate-20260410-113038-57244485
sess_SDA-2026-04-12-The abstract suggests that Aβ-tau synergy could explain negative results from an0.7034completed2026-04-12SDA-2026-04-12-gap-pubmed-20260410-180503-a7a03974
sess_SDA-2026-04-12-The abstract explicitly questions whether AD's hallmark pathologies induce choli0.7934completed2026-04-12SDA-2026-04-12-20260411-082446-2c1c9e2d
sess_SDA-2026-04-12-The debate identified a critical mechanistic gap between SCFA production by gut 0.7034completed2026-04-12SDA-2026-04-12-gap-debate-20260410-113021-6fbc6da4
sess_SDA-2026-04-04-How do neurodegeneration gene expression patterns in SEA-AD differ from other po0.7034completed2026-04-12SDA-2026-04-04-SDA-2026-04-04-gap-debate-20260403-222549-202
sess_SDA-2026-04-12-How does APOE4's beneficial immune function reconcile with its established role 0.7834completed2026-04-12SDA-2026-04-12-gap-pubmed-20260410-184126-b2c3e2e8
sess_SDA-2026-04-04-Which metabolic biomarkers can distinguish therapeutic response from disease pro0.7734completed2026-04-12SDA-2026-04-04-SDA-2026-04-04-gap-debate-20260403-222618-c69
sess_SDA-2026-04-12-Why have numerous phase 3 clinical trials failed despite advances in understandi0.6735completed2026-04-12SDA-2026-04-12-gap-debate-20260410-145418-c1527e7b
sess_SDA-2026-04-04-How do astrocyte-neuron metabolic interactions change during disease progression0.8634completed2026-04-12SDA-2026-04-04-SDA-2026-04-04-gap-debate-20260403-222618-e6a
sess_SDA-2026-04-04-What are the critical protein expression changes and post-translational modifica0.6834completed2026-04-12SDA-2026-04-04-frontier-proteomics-1c3dba72
sess_SDA-2026-04-04-How do peripheral immune system alterations influence CNS pathology and neurodeg0.7634completed2026-04-12SDA-2026-04-04-frontier-immunomics-e6f97b29
sess_SDA-2026-04-04-How do peripheral immune system alterations influence CNS pathology and neurodeg0.7834completed2026-04-12SDA-2026-04-04-frontier-immunomics-e6f97b29
sess_SDA-2026-04-04-How do structural and functional connectivity changes in the human brain connect0.7134completed2026-04-12SDA-2026-04-04-frontier-connectomics-84acb35a
sess_SDA-2026-04-09-The debate mentioned tau PTM targeting but did not identify which modifications 0.8434completed2026-04-12SDA-2026-04-09-gap-debate-20260409-201742-1e8eb3bd
sess_SDA-2026-04-09-The debate mentioned tau PTM targeting but did not identify which modifications 0.7134completed2026-04-12SDA-2026-04-09-gap-debate-20260409-201742-1e8eb3bd
sess_SDA-2026-04-04-Investigate prion-like spreading of tau pathology through connected brain region0.9034completed2026-04-12SDA-2026-04-04-gap-tau-prop-20260402003221
sess_sda-2026-04-01-Mitochondrial transfer between neurons and glia?0.7134completed2026-04-12sda-2026-04-01-gap-20260401231108
sess_sda-2026-04-01-Protein aggregation cross-seeding across neurodegenerative diseases?0.7034completed2026-04-12sda-2026-04-01-gap-9137255b
sess_sda-2026-04-12-Which EV-derived biomarkers (phospho-tau, amyloid-beta, synaptic proteins, infla0.7534completed2026-04-12sda-2026-04-12-ev-ad-biomarkers
sess_sda-2026-04-01-PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns 0.6934completed2026-04-12sda-2026-04-01-gap-005
sess_sda-2026-04-01-RNA binding protein dysregulation across ALS FTD and AD0.7234completed2026-04-12sda-2026-04-01-gap-v2-68d9c9c1
sess_SDA-2026-04-12-Do bacterial curli amyloids cross the blood-brain barrier to directly seed α-syn0.8434completed2026-04-12SDA-2026-04-12-gap-debate-20260410-112927-b4535f82
sess_SDA-2026-04-04-How does microglial priming contribute to early Alzheimer's disease pathology? F0.8034completed2026-04-12SDA-2026-04-04-gap-neuroinflammation-microglial-20260404
sess_SDA-2026-04-04-Investigate mechanistic links between early microglial priming states, neuroinfl0.8644completed2026-04-12SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
sess_SDA-2026-04-04-Investigate mechanistic links between early microglial priming states, neuroinfl0.9575completed2026-04-12SDA-2026-04-04-gap-20260404-microglial-priming-early-ad
sess_SDA-2026-04-12-What is the actual quantitative contribution of FcRn-mediated transcytosis to BB0.9176completed2026-04-12SDA-2026-04-12-gap-debate-20260410-112908-13c403ee
sess_sda-2026-04-01-TDP-43 undergoes liquid-liquid phase separation that becomes pathological. Small0.8476completed2026-04-12sda-2026-04-01-gap-006
sess_SDA-2026-04-03-Does neuroplasticity decline with age?0.5006enrolling2026-04-11
DA-2026-04-11-093252TDP-43 phase separation therapeutics for ALS-FTD0.3406enrolling2026-04-11
DA-2026-04-03-001What are novel CRISPR-based therapies for Huntington's disease?0.5007enrolling2026-04-11
debate-test-enrollmeDoes neuroplasticity decline with age?0.5006enrolling2026-04-11
debate-test-gap-enroTest debate on neuroplasticity mechanisms0.5006enrolling2026-04-11
sess_SDA-2026-04-11-Does reduced Prevotellaceae abundance cause PD pathology or result from it?0.9574completed2026-04-11SDA-2026-04-11-gap-debate-20260410-111558-f9487fea
sess_SDA-2026-04-01-Investigate how lipid raft composition (cholesterol metabolism, sphingolipids) c0.9375completed2026-04-11SDA-2026-04-01-gap-lipid-rafts-2026-04-01
sess_SDA-2026-04-11-TDP-43 phase separation therapeutics for ALS-FTD0.9574completed2026-04-11sda-2026-04-01-gap-006
sess_SDA-2026-04-04-How do alterations in brain lipid metabolism—including gangliosides, phospholipi0.8464completed2026-04-11SDA-2026-04-04-frontier-lipidomics-dcdbc360
sess_SDA-2026-04-04-How do peripheral immune system alterations influence CNS pathology and neurodeg0.5004completed2026-04-11SDA-2026-04-04-frontier-immunomics-e6f97b29
sess_SDA-2026-04-04-How do structural and functional connectivity changes in the human brain connect0.4404completed2026-04-11SDA-2026-04-04-frontier-connectomics-84acb35a
sess_SDA-2026-04-04-What are the critical protein expression changes and post-translational modifica0.5604completed2026-04-11SDA-2026-04-04-frontier-proteomics-1c3dba72
sess_SDA-2026-04-04-Epigenetic reprogramming in aging neurons0.9574completed2026-04-10SDA-2026-04-04-gap-epigenetic-reprog-b685190e
sess_SDA-2026-04-08-The abstract identifies tissue-specific networks that may underlie Mendelian dis0.9576completed2026-04-10SDA-2026-04-08-gap-pubmed-20260406-062222-b5f44522
sess_SDA-2026-04-08-While the abstract mentions identifying subcellular roles of protein interaction0.9577completed2026-04-10SDA-2026-04-08-gap-pubmed-20260406-062222-cc3bcb47
sess_SDA-2026-04-08-The abstract shows that dilncRNAs drive molecular crowding of DDR proteins into 0.9077completed2026-04-10SDA-2026-04-08-gap-pubmed-20260406-062229-35a642ca
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