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Debates

915 items
IdQuestionQuality ScoreNum Hypotheses GeneratedNum RoundsStatusCreated AtAnalysis Id
sess_SDA-2026-04-14-The abstract reveals FUS has a chaperone-like function regulating TAZ condensate0.8154completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-184155-2ff305ca
sess_SDA-2026-04-14-This study shows APOE4 carriers have enhanced beneficial innate immune responses0.6004completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-184126-b2c3e2e8
sess_SDA-2026-04-14-The abstract identifies APOE4's primary effect on oligodendrocyte cholesterol me0.6934completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-193244-89904941
sess_SDA-2026-04-14-The abstract reveals contradictory evidence where clusterin is proposed as a pro0.7234completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-193701-11582758
sess_SDA-2026-04-15-The debate revealed contradictory evidence about CD8+ T cell roles in neurodegen0.7634completed2026-04-16SDA-2026-04-15-gap-debate-20260410-112400-454036f1
sess_SDA-2026-04-15-The debate raised whether SST/PV interneuron dysfunction represents adaptive com0.7634completed2026-04-16SDA-2026-04-15-gap-debate-20260410-112441-f2afffb3
sess_SDA-2026-04-15-Despite the debate focusing on SEA-AD transcriptomic data, no actual gene expres0.7634completed2026-04-16SDA-2026-04-15-gap-debate-20260410-112607-0a3749ea
sess_SDA-2026-04-15-The debate established that ceramide accumulation affects amyloid-β processing b0.8434completed2026-04-16SDA-2026-04-15-gap-debate-20260410-112819-e40e0fa2
sess_SDA-2026-04-15-The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synap0.7134completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-075338-35f913fb
sess_SDA-2026-04-15-This finding contradicts the established paradigm that autophagy is generally pr0.7434completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-075356-20920528
sess_SDA-2026-04-15-The study demonstrates that apoE is absolutely required for CAA development, as 0.7134completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-083043-759b4c5e
sess_SDA-2026-04-15-The study demonstrates that SGMS1 elevation correlates with increased Aβ and tha0.7534completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-083737-59771b32
sess_SDA-2026-04-15-This study reveals SYNGAP1 expression and function in radial glia before synapto0.7834completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-084510-fbfafe2c
sess_SDA-2026-04-15-The abstract shows p53 is a central regulator of C9orf72-mediated neurodegenerat0.6134completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-090658-7651c1d2
sess_SDA-2026-04-15-The abstract identifies BACE1 as an attractive drug target but doesn't address i0.7634completed2026-04-16SDA-2026-04-15-gap-pubmed-20260411-093843-0a9326c2
sess_SDA-2026-04-14-The authors evaluate several ALS-associated mutations in OPTN's leucine-zipper d0.9574completed2026-04-16SDA-2026-04-14-gap-pubmed-20260410-183548-043c7918
sess_SDA-2026-04-14-The abstract describes a counterintuitive finding where loss-of-function P/Q mut0.9574completed2026-04-15SDA-2026-04-14-gap-pubmed-20260410-181156-feec7bd3
sess_SDA-2026-04-15-The abstract claims C. butyricum-GLP-1 crosses the BBB and binds to GLP-1 recept0.9574completed2026-04-15SDA-2026-04-15-gap-pubmed-20260411-093924-7330920b
sess_SDA-2026-04-15-The study shows deferiprone rescues wild-type cells but exacerbates toxicity in 0.9574completed2026-04-15SDA-2026-04-15-gap-pubmed-20260411-092119-691e1977
sess_SDA-2026-04-15-The abstract reveals an unexpected contradiction where PRKN activation, normally0.9174completed2026-04-15SDA-2026-04-15-gap-pubmed-20260411-082509-118fcb37
sess_SDA-2026-04-15-The abstract shows that acute neuroinflammation becomes persistent with a specif0.8374completed2026-04-15SDA-2026-04-15-gap-pubmed-20260411-075425-2feffb0c
sess_SDA-2026-04-15-The abstract challenges the rationale for using microtubule-stabilizing drugs in0.6804completed2026-04-15SDA-2026-04-15-gap-pubmed-20260410-100455-ff18091d
sess_SDA-2026-04-15-The debate highlighted tau prion-like transmission but did not resolve how diffe0.5704completed2026-04-15SDA-2026-04-15-gap-debate-20260410-112730-24052bbe
sess_SDA-2026-04-15-While TREM2 was identified as critical for microglial senescence, the debate lac0.7344completed2026-04-15SDA-2026-04-15-gap-debate-20260410-112522-57d1cc4f
sess_SDA-2026-04-14-The abstract shows TYROBP deficiency is neuroprotective despite being required f0.5604completed2026-04-15SDA-2026-04-14-gap-pubmed-20260411-072446-a32fa49c
sess_SDA-2026-04-14-The study demonstrates that exercise-conditioned plasma transfers cognitive bene0.9574completed2026-04-15SDA-2026-04-14-gap-pubmed-20260410-191046-15921012
sess_SDA-2026-04-14-The abstract describes astrocyte phenotypic heterogeneity (A1/A2) but doesn't ex0.6604completed2026-04-15SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04
sess_SDA-2026-04-02-0.9574completed2026-04-15SDA-2026-04-02-gap-v2-e1e1b7c3
sess_SDA-2026-04-14-The study shows dramatic functional recovery and muscle re-innervation after cyt0.8574completed2026-04-15SDA-2026-04-14-gap-pubmed-20260410-181356-57d1f917
sess_SDA-2026-04-14-The abstract shows V1613M variant reduces amyloid plaques and damage in 5xFAD mi0.6004completed2026-04-15SDA-2026-04-14-gap-pubmed-20260410-180532-e8930cb8
sess_SDA-2026-04-14-The finding that Mertk/Axl deficiency increases viral susceptibility contradicts0.7504completed2026-04-15SDA-2026-04-14-gap-pubmed-20260410-174607-708e8d91
sess_SDA-2026-04-15-The debate identified a critical therapeutic window when astrocytic ketone produ0.8534completed2026-04-15SDA-2026-04-15-gap-debate-20260410-112330-9abf86eb
sess_SDA-2026-04-15-What molecular mechanisms mediate SPP1-induced microglial phagocytic activation 0.9575completed2026-04-15SDA-2026-04-15-gap-pubmed-20260406-062118-e3613755
sess_SDA-2026-04-13-The authors explicitly state that the effects of these novel genes (MATR3, CHCHD0.7134completed2026-04-14SDA-2026-04-13-gap-pubmed-20260410-165527-8256a071
sess_SDA-2026-04-13-The debate proposed K280 acetylation creates a β-sheet nucleation interface but 0.8634completed2026-04-14SDA-2026-04-13-gap-debate-20260412-094556-86f36bb3
sess_SDA-2026-04-13-The debate proposed K280 acetylation creates a β-sheet nucleation interface but 0.7434completed2026-04-14SDA-2026-04-13-gap-debate-20260412-094556-86f36bb3
sess_SDA-2026-04-13-The debate outlined peripheral immune involvement but failed to address the prec0.7834completed2026-04-14SDA-2026-04-13-gap-debate-20260411-064946-4940f331
sess_SDA-2026-04-13-The debate outlined peripheral immune involvement but failed to address the prec0.6734completed2026-04-14SDA-2026-04-13-gap-debate-20260411-064946-4940f331
sess_SDA-2026-04-13-The abstract reports extraordinary dopamine increases (>500-fold in drug-free pa0.6734completed2026-04-14SDA-2026-04-13-gap-pubmed-20260410-145531-5c4e7b59
sess_SDA-2026-04-13-The study shows homozygous R136S fully rescues APOE4-driven pathology while hete0.8134completed2026-04-14SDA-2026-04-13-gap-pubmed-20260410-145358-185db2c8
sess_SDA-2026-04-13-The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro0.6834completed2026-04-14SDA-2026-04-13-gap-pubmed-20260410-165345-41805e1b
sess_SDA-2026-04-13-The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro0.6234completed2026-04-14SDA-2026-04-13-gap-pubmed-20260410-165345-41805e1b
sess_SDA-2026-04-13-The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro0.9234completed2026-04-14SDA-2026-04-13-gap-pubmed-20260410-165345-41805e1b
sess_SDA-2026-04-13-Despite FDA warnings and a 315% increased erythrocytosis risk with TRT, the asso0.8334completed2026-04-14SDA-2026-04-13-gap-pubmed-20260410-155308-2c6815fb
sess_SDA-2026-04-13-The study shows that MCT1 disruption leads to axon degeneration and neuron death0.7834completed2026-04-14SDA-2026-04-13-gap-pubmed-20260410-170325-196c7ee5
sess_SDA-2026-04-13-The study shows that MCT1 disruption leads to axon degeneration and neuron death0.8234completed2026-04-13SDA-2026-04-13-gap-pubmed-20260410-170325-196c7ee5
sess_SDA-2026-04-13-The study shows VCP-mutant astrocytes exhibit hypoxia response activation withou0.7834completed2026-04-13SDA-2026-04-13-gap-pubmed-20260410-170057-1bea7d88
sess_SDA-2026-04-13-This study identifies oligodendrocytes as drivers of neuroinflammation in PD, co0.7934completed2026-04-13SDA-2026-04-13-gap-pubmed-20260410-150500-e110aab9
sess_SDA-2026-04-13-The title suggests B cells actively maintain tolerance to AQP4, but the specific0.6634completed2026-04-13SDA-2026-04-13-gap-pubmed-20260410-142329-c1db787b
sess_SDA-2026-04-13-How does PIKFYVE inhibition activate unconventional protein clearance via exocyt0.6304completed2026-04-13SDA-2026-04-13-gap-pubmed-20260410-143119-8ae42941
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